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Fanconi Anemia, Complementation Group C Proteins (FANCC)

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). Additionally we are shipping Fanconi Anemia, Complementation Group C Antibodies (101) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FANCC 2176 Q00597
FANCC 14088  
FANCC 24361  
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Top Fanconi Anemia, Complementation Group C Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,595.17
Details

FANCC Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Fanconi Anemia, Complementation Group C (FANCC) Interaction Partners

Human Fanconi Anemia, Complementation Group C (FANCC) interaction partners

  1. Lung adenocarcinomas in both male and female patients were associated with (a) genotypic polymorphisms of FANCC and FANCD1 (show BRCA2 Proteins).

  2. Israeli ATM (show ATM Proteins), BLM, and FANCC heterozygous mutation carriers are not at an increased risk for developing cancer.

  3. FANCC interacts and co-localizes with STMN1 (show STMN1 Proteins) at centrosomes during mitosis. We also showed that FANCC is required for STMN1 (show STMN1 Proteins) phosphorylation.

  4. FANCC interferes with UNC5A's functions in apoptosis and suggest that FANCC may participate in developmental processes through association with the dependence receptor UNC5A (show UNC5A Proteins).

  5. The successful in vitro repair of the mutated Fanconi anemia (show PALB2 Proteins) FANCC gene using the CRISPR/Cas9 system has been described.

  6. Data indicate that TLR-indu (show IL1B Proteins)ced IL-1beta overproduction in FANCA- and FANCC-deficie (show CRK Proteins)nt mononuclear phagocyte cell lines and primary cells requires activation of the inflammasome.

  7. deregulations of the FANCC-mediated DNA damage repair pathway and the PTCH1 (show PTCH1 Proteins)-associated sonic hedgehog (show SHH Proteins) pathway are associated with the development of early dysplastic head and neck lesions.

  8. we identified faults in two genes, Fanconi C and Bloom helicase( FANCC and BLM), in six families. Faults in these genes appear to increase the risk of developing breast cancer

  9. FANCC polymorphisms might be associated with the obstructive symptoms in allergic diseases.

  10. FA DNA repair genes, FANCD2, FANCL (show FANCL Proteins), and FANCC, are transcriptionally upregulated differently in melanoma compared with non-melanoma skin cancer

Mouse (Murine) Fanconi Anemia, Complementation Group C (FANCC) interaction partners

  1. Data show that Fanconi anemia (show PALB2 Proteins), complementation group C protein (show HNRNPC Proteins) knockout (Fancc -/-) mice develop hematopoietic chromosomal instability followed by leukemia in an age-dependent manner.

  2. Loss of Fancc Impairs Antibody-Secreting Cell Differentiation in Mice through Deregulating the Wnt (show WNT2 Proteins) Signaling Pathway

  3. Combined deficiency of Foxo3a and Fancc or Fancd2 not only impairs the self-renewal capacity but also markedly increases the apoptosis of neural stem and progenitor cells (NSPCs), leading to defective neurogenesis.

  4. Using mice deficient in both Mus81 (show MUS81 Proteins) and the FA pathway protein FancC, we show both proteins cooperate in parallel pathways, as concomitant loss of FancC and Mus81 (show MUS81 Proteins) triggered cell-type-specific proliferation arrest, apoptosis and DNA damage accumulation in utero.

  5. Loss of FANCC leads to a drastic increase in stalled/collapsed forks in cells carrying an Mcm4 (show MCM4 Proteins) missense mutation.

  6. FANCC is most likely to be critical for resistance to DNA cross-linking drug-induced DNA damage in cells transformed by JAK2 (show JAK2 Proteins) V617F mutant.

  7. Data indicate that IL-1beta (show IL1B Proteins) overproduction from FANCC-deficient macrophages is p38 (show CRK Proteins) dependent.

  8. Loss of FANCC expression results in an impaired emergency granulopoiesis response in a transgenic mouse model of Fanconi anemia (show PALB2 Proteins).

  9. Compromised hematopoiesis in Fancc(-/-) animals is developmentally programmed and does not arise de novo in bone marrow.

  10. Double-mutant Fancc(-/-);Fancg (show FANCG Proteins)(-/-) mice develop spontaneous hematologic sequelae including bone marrow failure, acute myeloid leukemia (show BCL11A Proteins), myelodysplasia and complex random chromosomal abnormalities that the single-mutant mice do not.

Fanconi Anemia, Complementation Group C (FANCC) Protein Profile

Protein Summary

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity\; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group C.

Gene names and symbols associated with FANCC

  • Fanconi anemia, complementation group C (FANCC)
  • Fanconi anemia, complementation group C (fancc)
  • Fanconi anemia, complementation group C (Fancc)
  • BB116513 protein
  • FA3 protein
  • FAC protein
  • Facc protein
  • FANCC protein
  • zgc:154105 protein

Protein level used designations for FANCC

Fanconi anemia, complementation group C protein , Fanconi anemia C , Fanconi anemia, complementation group C , fanconi anemia group C protein-like , Fanconi anemia group C protein-like , Fanconi anemia group C protein , Fanconi anemia group C protein homolog

GENE ID SPECIES
427468 Gallus gallus
692127 Danio rerio
709398 Macaca mulatta
100061359 Equus caballus
100329211 Xenopus laevis
100344788 Oryctolagus cuniculus
100409306 Callithrix jacchus
100461880 Pongo abelii
2176 Homo sapiens
465257 Pan troglodytes
14088 Mus musculus
24361 Rattus norvegicus
281762 Bos taurus
607277 Canis lupus familiaris
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