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Fanconi Anemia, Complementation Group E Proteins (FANCE)

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). Additionally we are shipping Fanconi Anemia, Complementation Group E Antibodies (68) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FANCE 2178 Q9HB96
Mouse FANCE FANCE 72775  
Rat FANCE FANCE 309643  
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Top Fanconi Anemia, Complementation Group E Proteins at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details

FANCE Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,

More Proteins for Fanconi Anemia, Complementation Group E (FANCE) Interaction Partners

Human Fanconi Anemia, Complementation Group E (FANCE) interaction partners

  1. A novel alternative splicing event of the FANCE gene has been characterized. FANCEDelta4 cannot support the activation of the FANC-BRCA pathway and DNA repair.

  2. a phenylalanine located at the highly conserved extreme C terminus, referred to as Phe-522, is a critical residue for mediating the monoubiquitination of the FANCD2-FANCI (show FANCI Proteins) complex.

  3. FANCE protein is part of the FA nuclear complex, binding FANCC & FAN (show PALB2 Proteins)CD2. It is required for the nuclear accumulation of FANCC and provides a bridge between the FA complex and FANCD2. FANCC mutants do not bind FANCE or prevent chromosome breakage.

  4. This Fanconi anemia protein promotes the nuclear accumulation of FANCC (show FANCC Proteins).

  5. FANCC (show FANCC Proteins), FANCE, and FANCD2 form a ternary complex in the Fanconi anemia (show PALB2 Proteins) DNA damage response pathway

  6. nuclear accumulation of FANCE does not rely solely on its nuclear localization signal motifs, but also on FANCC (show FANCC Proteins)

  7. Chk1-mediated phosphorylation of FANCE is required for a function independent of FANCD2 monoubiquitination.

  8. Disease-associated mutations disrupt the FANCE-FANCD2 interaction, providing structural insight into the molecular mechanisms of Fanconi Anaemia pathogenesis.

Mouse (Murine) Fanconi Anemia, Complementation Group E (FANCE) interaction partners

  1. Primary ovarian insufficiency is induced by Fance mutation in a mouse model.

  2. The fact that defects in the human ortholog result in Fanconi anemia (show PALB2 Proteins) disease suggests that this protein has a critical function and is likely evolutionarily conserved.

Fanconi Anemia, Complementation Group E (FANCE) Protein Profile

Protein Summary

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity\; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group E.

Gene names and symbols associated with FANCE

  • Fanconi anemia, complementation group E (FANCE)
  • Fanconi anemia, complementation group E (fance)
  • Fanconi anemia, complementation group E (Fance)
  • 2810451D06Rik protein
  • AI415634 protein
  • AW209126 protein
  • FACE protein
  • FAE protein
  • FANCE protein
  • RGD1561045 protein

Protein level used designations for FANCE

Fanconi anemia, complementation group E , Fanconi anemia E , Fanconi anemia group E protein , fanconi anemia group E protein-like , Fanconi anemia group E protein-like

GENE ID SPECIES
419891 Gallus gallus
565685 Danio rerio
747546 Pan troglodytes
100126687 Xenopus (Silurana) tropicalis
100400262 Callithrix jacchus
100446212 Pongo abelii
2178 Homo sapiens
608172 Canis lupus familiaris
513464 Bos taurus
72775 Mus musculus
309643 Rattus norvegicus
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