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The protein encoded by FAIM protects against death receptor-triggered apoptosis and regulates B-cell signaling and differentiation. Additionally we are shipping FAIM Antibodies (92) and FAIM Proteins (8) and many more products for this protein.
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FAIM modulates IGF-1 (show IGF1 ELISA Kits)-induced Akt (show AKT1 ELISA Kits) activation and IRF4 (show IRF4 ELISA Kits) expression and has a role in multiple myeloma cell survival
FAIM (1-90) was crystallized and diffracted to a resolution of 2.5 A; the crystal belonged to space group P3(1), with unit-cell parameters a=b=58.02, c=71.11 A, alpha=beta=90, gamma=120 degrees.
Human keratinocytes were transfected with either Flip, Faim, or Lifeguard (LFG (show FAIM2 ELISA Kits)). Our results suggest that heterotopic expression of antiapoptotic proteins can induce the resistance of keratinocytes to a major mechanism of rejection.
Expression of the long form of Fas apoptotic inhibitory molecule (FAIML) results in the protection of neurons from the cytotoxic actions of death ligands.
FAIM acts to specifically enhance CD40 (show CD40 ELISA Kits) signaling for NF-kappaB (show NFKB1 ELISA Kits) activation, IRF-4 (show IRF4 ELISA Kits) expression, and BCL-6 (show BCL6 ELISA Kits) down-regulation in vitro, but has no effect on its own
defined a TCR-induced FAIM/Akt (show AKT1 ELISA Kits)/Nur77 (show NR4A1 ELISA Kits) signaling axis that is critical for modulating the apoptosis of developing thymocytes
The NMR solution structure of the C-terminal domain of murine FAIM is solved in isolation and revealed to be a novel protein fold, a noninterleaved seven-stranded beta-sandwich.
FAIM plays a novel role in modulating Fas (show FAS ELISA Kits)-mediated apoptosis and acts through influencing the expression of c-FLIP (show CFLAR ELISA Kits) and regulating the physical binding of caspase-8 (show CASP8 ELISA Kits) to Fas (show FAS ELISA Kits).
FAIM is expressed in germinal center B cells, enhances interferon (show IFNA ELISA Kits) regulatory factor (IRF)4 (show IRF4 ELISA Kits) expression, and is in turn positively regulated through IRF4 (show IRF4 ELISA Kits) in a positive reinforcing (i.e., feed-forward) system.
The protein encoded by this gene protects against death receptor-triggered apoptosis and regulates B-cell signaling and differentiation. Several transcript variants encoding different isoforms have been found for this gene.
Fas apoptotic inhibitory molecule
, fas apoptotic inhibitory molecule 1
, Fas apoptosis inhibitory molecule 1
, fas apoptotic inhibitory molecule 1-like