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The protein encoded by FAIM protects against death receptor-triggered apoptosis and regulates B-cell signaling and differentiation. Additionally we are shipping FAIM Antibodies (88) and FAIM Kits (1) and many more products for this protein.
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FAIM modulates IGF-1 (show IGF1 Proteins)-induced Akt (show AKT1 Proteins) activation and IRF4 (show IRF4 Proteins) expression and has a role in multiple myeloma cell survival
FAIM (1-90) was crystallized and diffracted to a resolution of 2.5 A; the crystal belonged to space group P3(1), with unit-cell parameters a=b=58.02, c=71.11 A, alpha=beta=90, gamma=120 degrees.
Human keratinocytes were transfected with either Flip, Faim, or Lifeguard (LFG (show FAIM2 Proteins)). Our results suggest that heterotopic expression of antiapoptotic proteins can induce the resistance of keratinocytes to a major mechanism of rejection.
Expression of the long form of Fas apoptotic inhibitory molecule (FAIML) results in the protection of neurons from the cytotoxic actions of death ligands.
FAIM acts to specifically enhance CD40 (show CD40 Proteins) signaling for NF-kappaB (show NFKB1 Proteins) activation, IRF-4 (show IRF4 Proteins) expression, and BCL-6 (show BCL6 Proteins) down-regulation in vitro, but has no effect on its own
defined a TCR-induced FAIM/Akt (show AKT1 Proteins)/Nur77 (show NR4A1 Proteins) signaling axis that is critical for modulating the apoptosis of developing thymocytes
The NMR solution structure of the C-terminal domain of murine FAIM is solved in isolation and revealed to be a novel protein fold, a noninterleaved seven-stranded beta-sandwich.
FAIM plays a novel role in modulating Fas (show FAS Proteins)-mediated apoptosis and acts through influencing the expression of c-FLIP (show CFLAR Proteins) and regulating the physical binding of caspase-8 (show CASP8 Proteins) to Fas (show FAS Proteins).
FAIM is expressed in germinal center B cells, enhances interferon (show IFNA Proteins) regulatory factor (IRF)4 (show IRF4 Proteins) expression, and is in turn positively regulated through IRF4 (show IRF4 Proteins) in a positive reinforcing (i.e., feed-forward) system.
The protein encoded by this gene protects against death receptor-triggered apoptosis and regulates B-cell signaling and differentiation. Several transcript variants encoding different isoforms have been found for this gene.
Fas apoptotic inhibitory molecule
, fas apoptotic inhibitory molecule 1
, Fas apoptosis inhibitory molecule 1
, fas apoptotic inhibitory molecule 1-like