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Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. Additionally we are shipping FAIM3 Antibodies (65) and FAIM3 Kits (11) and many more products for this protein.
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Overexpression of TOSO gene is associated with chronic lymphocytic leukemia.
Toso/FcmuR is an IgM receptor capable of activating signaling molecules and whose expression alone is not inherently antiapoptotic.
Overexpression of TOSO in chronic lymphocytic leukemia is associated with disease progression.
TOSO/FAIM3 may play a role in immune surveillance and contribute to B (show TDO2 Proteins) cell activation (show BLNK Proteins)
we demonstrate that the immune specific cell surface molecule Toso exhibits antiapoptotic effects on death receptor signaling by a novel regulatory mechanism involving the adaptor kinase RIP1 (show UQCRFS1 Proteins)
TOSO is overexpressed and correlated with disease progression in chronic lymphocytic leukemia.
This review focuses on possible functional consequences of Plasmodium falciparum EMP1 protein interaction with the IgM receptor, including interference with immunologic signaling and clearance mechanisms and blocking of specific antibody binding.
These results identify TOSO/FAIM3 as a receptor for IgM
enzymatically modified-LDL-generated foam cells are protected from cell death most likely through the expression of TOSO by a FLIP(L) independent mechanism
demonstrated a 5.6-fold increase of TOSO protein in circulating CLL cells and lymph nodes
Toso has an essential role in the differentiation and maturation of iDCs, a process that is required for the control of persistence-prone virus infection.
these findings suggest that FcmuR plays important roles in the regulation of auto-antibody production, Mott cell formation and the differentiation of MZ B cells into plasma cells in B6.MRL Fas (lpr/lpr (show FAS Proteins)) mice.
FCMR is required for B cell differentiation and homeostasis, the prevention of autoreactive B cells, and responsiveness to antigenic challenge.
Toso is a unique regulator of inflammatory autoimmune responses with a protective role against experimental autoimmune encephalomyelitis
Toso is a unique regulator of innate immune responses during bacterial infection and septic shock.
These results identify TOSO/FAIM3 as a receptor for IgM (show CD40LG Proteins)
mTOSO overexpressing primary T lymphocytes are resistant to Fas/Fas (show FAS Proteins) ligand (show FASL Proteins)-induced apoptosis.
Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009
Fas apoptotic inhibitory molecule 3
, Fc mu receptor
, IgM Fc receptor
, fas apoptotic inhibitory molecule 3
, immunoglobulin mu Fc receptor
, regulator of Fas-induced apoptosis Toso