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FEZ1 is an ortholog of the C. Additionally we are shipping FEZ1 Antibodies (56) and many more products for this protein.
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FEZ1 promotes HIV-1 infection in non-neuronal cells via direct binding to the capsid and kinesin-1 to move the virus into the cell nucleus.
SCOC (show SCOC Proteins) forms a stable homogeneous complex with the coiled coil domain of FEZ1 (show LZTS1 Proteins). SCOC (show SCOC Proteins) dimerization and the SCOC (show SCOC Proteins) surface residue R117 are important for this interaction.
Studies indicate that FEZ1 (fasciculation and elongation protein zeta 1 (show LZTS1 Proteins)), SCOCO (short coiled-coil protein (show SCOC Proteins)) and kinesins (kinesin heavy chain (show KIF5A Proteins)) are involved in biological transport process.
Short Disrupted-in-Schizophrenia (DISC)1 splice variants show reduced or no binding to NDEL1 and phosphodiesterase (PDE)4B proteins but fully interact with FEZ1 and GSK3beta.
FEZ1 (show LZTS1 Proteins) operates as a kinesin adaptor for the transport of Stx (show ST8SIA2 Proteins), with cargo loading and unloading being regulated by protein kinases.
The data of this study suggested that FEZ1 (show LZTS1 Proteins) may play important roles in human astrocytes, and that mood stabilizers might exert their cytoprotective and mood-stabilizing effects by inducing FEZ1 (show LZTS1 Proteins) expression in astrocytes.
Genetic association analysis of two independent cohorts of (show DISC1 Proteins)schizophrenia patients and healthy controls reveals an epistatic interaction between FEZ1 and disrupted in schizophrenia (DISC)1.
FEZ2 (show FEZ2 Proteins) interacted with 59 proteins and that of these only 40 interacted with FEZ1 (show LZTS1 Proteins).
Demonstrated the formation of an intermolecular disulfide bond through FEZ1 (show LZTS1 Proteins) Cys (show DNAJC5 Proteins)-133, which appears to be essential for dimerization.
Studies indicate that suppression of FEZ1 (show LZTS1 Proteins) expression in cultured embryonic neurons causes deficiency of neuronal differentiation.
Dendrite growth depends on degradation of FEZ1 regulated by Cdc20 (show CDC20 Proteins)/APC (show APC Proteins).
Fezzeta-1 interacts with disrupted in schizophrenia (DISC)1 (show DISC1 Proteins) to synergistically regulate dendritic growth of newborn neurons in the adult mouse hippocampus.
Fez1 is mainly expressed in cortical layers V and VI, not in gamma-aminobutyric acid neurons but in pyramidal neurons, the projection neurons of the cerebral cortex. Immunohistochemistry also shows that Fez1 is expressed in deep layers of the neocortex.
investigated the role of FEZ1 in brain development and the pathogenesis of schizophrenia by generating mice that lack Fez1
This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described.
fasciculation and elongation protein zeta-1
, zygin I
, protein kinase C-binding protein Zeta1