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FEZ1 is an ortholog of the C. Additionally we are shipping FEZ1 Proteins (4) and many more products for this protein.
Showing 10 out of 59 products:
Human Polyclonal FEZ1 Primary Antibody for ELISA, WB - ABIN1002295
Kuroda, Nakagawa, Tokunaga, Tatematsu, Tanizawa: Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein. in The Journal of cell biology 1999
Show all 4 Pubmed References
Human Polyclonal FEZ1 Primary Antibody for ELISA, WB - ABIN251699
Kang, Burdick, Kim, Duan, Guo, Sailor, Jung, Ganesan, Choi, Pradhan, Lu, Avramopoulos, Christian, Malhotra, Song, Ming: Interaction between FEZ1 and DISC1 in regulation of neuronal development and risk for schizophrenia. in Neuron 2011
Show all 2 Pubmed References
Human Monoclonal FEZ1 Primary Antibody for IF, WB - ABIN968638
Ishii, Baffa, Numata, Murakumo, Rattan, Inoue, Mori, Fidanza, Alder, Croce: The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors. in Proceedings of the National Academy of Sciences of the United States of America 1999
Show all 2 Pubmed References
Human Polyclonal FEZ1 Primary Antibody for WB - ABIN523131
McKnight, Jefferies, Alemu, Saunders, Howell, Johansen, Tooze: Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. in The EMBO journal 2012
FEZ1 (show LZTS1 Antibodies) promotes HIV-1 infection in non-neuronal cells via direct binding to the capsid and kinesin-1 to move the virus into the cell nucleus.
SCOC (show SCOC Antibodies) forms a stable homogeneous complex with the coiled coil domain of FEZ1 (show LZTS1 Antibodies). SCOC (show SCOC Antibodies) dimerization and the SCOC (show SCOC Antibodies) surface residue R117 are important for this interaction.
Studies indicate that FEZ1 (fasciculation and elongation protein zeta 1 (show LZTS1 Antibodies)), SCOCO (short coiled-coil protein (show SCOC Antibodies)) and kinesins (kinesin heavy chain (show KIF5A Antibodies)) are involved in biological transport process.
Short Disrupted-in-Schizophrenia (DISC)1 (show DISC1 Antibodies) splice variants show reduced or no binding to NDEL1 (show NDEL1 Antibodies) and phosphodiesterase (PDE (show ALDH7A1 Antibodies))4B proteins but fully interact with FEZ1 (show LZTS1 Antibodies) and GSK3beta (show GSK3b Antibodies).
FEZ1 (show LZTS1 Antibodies) operates as a kinesin adaptor for the transport of Stx (show ST8SIA2 Antibodies), with cargo loading and unloading being regulated by protein kinases.
The data of this study suggested that FEZ1 (show LZTS1 Antibodies) may play important roles in human astrocytes, and that mood stabilizers might exert their cytoprotective and mood-stabilizing effects by inducing FEZ1 (show LZTS1 Antibodies) expression in astrocytes.
Genetic association analysis of two independent cohorts of (show DISC1 Antibodies)schizophrenia patients and healthy controls reveals an epistatic interaction between FEZ1 and disrupted in schizophrenia (DISC)1.
FEZ2 (show FEZ2 Antibodies) interacted with 59 proteins and that of these only 40 interacted with FEZ1 (show LZTS1 Antibodies).
Demonstrated the formation of an intermolecular disulfide bond through FEZ1 (show LZTS1 Antibodies) Cys (show DNAJC5 Antibodies)-133, which appears to be essential for dimerization.
Studies indicate that suppression of FEZ1 (show LZTS1 Antibodies) expression in cultured embryonic neurons causes deficiency of neuronal differentiation.
Dendrite growth depends on degradation of FEZ1 regulated by Cdc20 (show CDC20 Antibodies)/APC (show APC Antibodies).
Fezzeta-1 interacts with disrupted in schizophrenia (DISC)1 (show DISC1 Antibodies) to synergistically regulate dendritic growth of newborn neurons in the adult mouse hippocampus.
Fez1 is mainly expressed in cortical layers V and VI, not in gamma-aminobutyric acid neurons but in pyramidal neurons, the projection neurons of the cerebral cortex. Immunohistochemistry also shows that Fez1 is expressed in deep layers of the neocortex.
investigated the role of FEZ1 in brain development and the pathogenesis of schizophrenia by generating mice that lack Fez1
This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described.
fasciculation and elongation protein zeta-1
, zygin I
, protein kinase C-binding protein Zeta1