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Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) Proteins (FSCN1)

FSCN1 encodes a member of the fascin family of actin-binding proteins. Additionally we are shipping Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) Antibodies (122) and Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) Kits (32) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FSCN1 14086 Q61553
FSCN1 683788 P85845
FSCN1 6624 Q16658
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Top Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) Proteins at antibodies-online.com

Showing 10 out of 18 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$739.20
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$756.80
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$3,366.00
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,393.50
Details
HOST_Escherichia coli (E. coli) Rat His tag   100 μg Log in to see 11 to 13 Days
$767.80
Details
HOST_Escherichia coli (E. coli) Human FITC   1 mg Log in to see 3 to 4 Days
$3,035.21
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$364.64
Details

FSCN1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus) ,

Human ,
,

Top referenced Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) Proteins

  1. Human FSCN1 Protein expressed in Escherichia coli (E. coli) - ABIN667173 : Shin, Purdy Drew, Bartles, Wong, Grason: Cooperativity and frustration in protein-mediated parallel actin bundles. in Physical review letters 2010 (PubMed)
    Show all 2 references for ABIN667173

More Proteins for Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) (FSCN1) Interaction Partners

Fruit Fly (Drosophila melanogaster) Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) (FSCN1) interaction partners

  1. Alterations in nuclear Fascin levels result in defects in nucleolar morphology in both Drosophila follicles and cultured mammalian cells, suggesting that nuclear Fascin plays an important role in nucleolar architecture.

  2. essential for actin bundle initiation and stiffening during embryonic tracheal system development

  3. Fascin and Ena cooperate to extend and maintain robust filopodia of uniform thickness with aligned barbed ends by a unique mechanistic cycle.

  4. Fascin links Btl/FGFR signalling to the actin cytoskeleton during Drosophila tracheal morphogenesis.

  5. These data lead to the conclusion that prostaglandins regulate Fascin to control actin remodeling

  6. The terminal branchlets of different classes of neurons have distinctive dynamics and are formed on the basis of molecularly separable mechanisms; in particular, class III neurons require fascin for terminal branching whereas class IV neurons do not.

  7. The regulatory role of FascinS52 appears to be tissuespecific, and its importance might depend on the dynamics and the turnover rate of actin bundles between various cell types.

  8. Fascin deficiency does not impair 20-hydroxyecdysone response, but neurites fail to maintain their normal, nearly straight trajectory, instead forming curls and hooks. This is accompanied by abnormally distributed filamentous actin.

  9. Fascin is required for plasmatocyte migration, both as these cells undergo developmental dispersal and during an inflammatory response to epithelial wounding.

  10. study found that Rab35 (show RAB35 Proteins) regulates the assembly of actin (show ACTB Proteins) filaments during bristle development; effect was mediated by the a (show ACTB Proteins)ctin-bundling protein fascin, which directly associated with active R (show RAB35 Proteins)ab35

Zebrafish Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) (FSCN1) interaction partners

  1. These data show that fscn1a-dependent filopodia are required in a subset of NC cells to promote cell migration and NC derivative formation

Mouse (Murine) Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) (FSCN1) interaction partners

  1. Fascin1 facilitates phagolysosomal fusion for killing of phagocytosed Listeria. It binds to LC3 (show MAP1LC3A Proteins), an autophagosome marker, both in vivo & in vitro. It plays a critical role in dendritic cell survivalduring Listeria infection.

  2. A tightly regulated phospho/dephospho-fascin cycle modulated by extracellular signals is required for the polarized morphology and migration in neuroblasts, thus contributing to efficient neurogenesis.

  3. fascin 1 promotes cell migration and has a role in growth and cell cycle progression

  4. Suppression of fascin expression results in reduction of activation-induced migration and invasion in mouse monocytic leukemia (show KAT6B Proteins) RAW264.7 macrophages.

  5. Both STAT3 (show STAT3 Proteins) and NFkappaB are required for the cytokine-induced expression of fascin in cancer cells.

  6. fascin-1 is principally expressed in neural and mesenchymal derivatives during embryonic development

  7. We propose that fascin is a key specific actin cross-linker, providing stiffness for filopodial bundles, and that its dynamic behavior allows for efficient coordination between elongation and bundling of filopodial actin filaments.

  8. Fascin is a novel target of beta-catenin (show CTNNB1 Proteins)-TCF (show HNF4A Proteins) signaling and is expressed at the invasive front of human colon cancer

  9. Fascin mRNA & protein levels were significantly lower in the cultured ANXA2 (show ANXA2 Proteins)(-/-) cells than in cultured ANXA2 (show ANXA2 Proteins)(+/+) cells. ANXA2 (show ANXA2 Proteins) may be an inducer or enhancer of fascin expression at the transcription level.

  10. study found that Rab35 (show RAB35 Proteins) regulates the assembly of actin filaments in filopodia formation; effect was mediated by the actin-bundling protein fascin, which directly associated with active Rab35 (show RAB35 Proteins)

Human Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) (FSCN1) interaction partners

  1. Study demonstrates that FSCN1 is associated with increased risk of recurrence in pituitary adenomas and invasion, partially through modifying the expression of Notch (show NOTCH1 Proteins)/DLL pathway.

  2. The present study revealed an antioncogenic role of miR145 in gastric carcinoma via inhibition of FSCN1, and suggested that miR145 may be used for the treatment of gastric carcinoma.

  3. miR (show MLXIP Proteins)-145 negatively regulates the protein expression of its target FSCN1 in the NSCLC cell line H129.

  4. MiR (show MLXIP Proteins)-24 functions as a tumor suppressor in nasopharyngeal carcinoma through targeting FSCN1

  5. Strong fascin-1 expression was found in 14.3% of borderline epithelial tumors of the ovary and linked to features related to elevated risk of recurrence.

  6. FSCN1 plays an important role in non-small cell lung cancer progression and prognosis.

  7. Alterations in nuclear Fascin levels result in defects in nucleolar morphology in both Drosophila follicles and cultured mammalian cells, suggesting that nuclear Fascin plays an important role in nucleolar architecture.

  8. miR (show MLXIP Proteins)-145 regulates cell migration and invasion in gastric cancer primarily by directly targeting FSCN1.

  9. regulates translation through miR (show MLXIP Proteins)-155 and miR (show MLXIP Proteins)-125b, which target 3' UTR in TNF-alpha (show TNF Proteins) mRNA

  10. the anti-oncogenic activity of miR (show MLXIP Proteins)-133a may involve the inhibition of the target gene FSCN1. The present study suggested that miR (show MLXIP Proteins)-133a may be a potential therapeutic target in the treatment of gastric cancer.

Pig (Porcine) Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) (FSCN1) interaction partners

  1. FSCN1 gene plays an in prenatal skeletal muscle development and was a candidate gene for meat production trait.

Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) (FSCN1) Protein Profile

Protein Summary

This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15.

Gene names and symbols associated with FSCN1

  • singed (sn)
  • fascin homolog 1, actin-bundling protein (fscn1)
  • fascin homolog 1, actin-bundling protein a (Strongylocentrotus purpuratus) (fscn1a)
  • fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus) (Fscn1)
  • fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus) (FSCN1)
  • fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus) (Fscn1)
  • AI663989 protein
  • CG1536 protein
  • CG15331 protein
  • CG32858 protein
  • Dmel\\CG32858 protein
  • FAN1 protein
  • fascin protein
  • fascin-1 protein
  • fs(1)A1057 protein
  • fs(1)K418 protein
  • fs(1)K473 protein
  • fs(1)K743 protein
  • fs(1)K1421 protein
  • fs(1)M45 protein
  • fscn protein
  • fscn1 protein
  • HSN protein
  • MGC75811 protein
  • p55 protein
  • sb:cb589 protein
  • Sn protein
  • SNL protein
  • zgc:153632 protein

Protein level used designations for FSCN1

CG32858-PA , CG32858-PB , CG32858-PD , CG32858-PE , CG32858-PF , CG32858-PG , fascin , sn-PA , sn-PB , sn-PD , sn-PE , sn-PF , sn-PG , fascin-1 , fascin 1 , singed-like protein , 55 kDa actin-bundling protein , singed-like (fascin homolog, sea urchin)

GENE ID SPECIES
31717 Drosophila melanogaster
394733 Xenopus (Silurana) tropicalis
558271 Danio rerio
14086 Mus musculus
683788 Rattus norvegicus
397934 Xenopus laevis
6624 Homo sapiens
489880 Canis lupus familiaris
100286741 Sus scrofa
100733694 Cavia porcellus
507342 Bos taurus
416485 Gallus gallus
101108186 Ovis aries
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