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FSCN1 encodes a member of the fascin family of actin-binding proteins. Additionally we are shipping Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) Kits (28) and Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) Proteins (18) and many more products for this protein.
Showing 10 out of 214 products:
Dog (Canine) Polyclonal FSCN1 Primary Antibody for IF (p), IHC (p) - ABIN673011
Majchrzak, Lo Re, Gajewska, Bulkowska, Homa, Paw?owski, Motyl, Murphy, Król: Migrastatin analogues inhibit canine mammary cancer cell migration and invasion. in PLoS ONE 2013
Show all 2 Pubmed References
Dog (Canine) Polyclonal FSCN1 Primary Antibody for WB - ABIN610551
Attramadal, Arriza, Aoki, Dawson, Codina, Kwatra, Snyder, Caron, Lefkowitz: Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family. in The Journal of biological chemistry 1992
Show all 3 Pubmed References
Human Polyclonal FSCN1 Primary Antibody for WB - ABIN442669
Law, Li, Chou, Chen, Chan: Hyaluronic acid-dependent protection in H9C2 cardiomyocytes: a cell model of heart ischemia-reperfusion injury and treatment. in Toxicology 2013
Alterations in nuclear Fascin levels result in defects in nucleolar morphology in both Drosophila follicles and cultured mammalian cells, suggesting that nuclear Fascin plays an important role in nucleolar architecture.
essential for actin bundle initiation and stiffening during embryonic tracheal system development
Fascin and Ena cooperate to extend and maintain robust filopodia of uniform thickness with aligned barbed ends by a unique mechanistic cycle.
Fascin links Btl/FGFR signalling to the actin cytoskeleton during Drosophila tracheal morphogenesis.
These data lead to the conclusion that prostaglandins regulate Fascin to control actin remodeling
The terminal branchlets of different classes of neurons have distinctive dynamics and are formed on the basis of molecularly separable mechanisms; in particular, class III neurons require fascin for terminal branching whereas class IV neurons do not.
The regulatory role of FascinS52 appears to be tissuespecific, and its importance might depend on the dynamics and the turnover rate of actin bundles between various cell types.
Fascin deficiency does not impair 20-hydroxyecdysone response, but neurites fail to maintain their normal, nearly straight trajectory, instead forming curls and hooks. This is accompanied by abnormally distributed filamentous actin.
Fascin is required for plasmatocyte migration, both as these cells undergo developmental dispersal and during an inflammatory response to epithelial wounding.
study found that Rab35 (show RAB35 Antibodies) regulates the assembly of actin (show ACTB Antibodies) filaments during bristle development; effect was mediated by the a (show ACTB Antibodies)ctin-bundling protein fascin, which directly associated with active R (show RAB35 Antibodies)ab35
These data show that fscn1a-dependent filopodia are required in a subset of NC cells to promote cell migration and NC derivative formation
Fascin-1 expression, cadherin-17 expression, tumor size, and differentiation were independent risk factors for GC.
Fascin1 facilitates phagolysosomal fusion for killing of phagocytosed Listeria. It binds to LC3 (show MAP1LC3A Antibodies), an autophagosome marker, both in vivo & in vitro. It plays a critical role in dendritic cell survivalduring Listeria infection.
A tightly regulated phospho/dephospho-fascin cycle modulated by extracellular signals is required for the polarized morphology and migration in neuroblasts, thus contributing to efficient neurogenesis.
fascin 1 promotes cell migration and has a role in growth and cell cycle progression
Suppression of fascin expression results in reduction of activation-induced migration and invasion in mouse monocytic leukemia (show KAT6B Antibodies) RAW264.7 macrophages.
Both STAT3 (show STAT3 Antibodies) and NFkappaB are required for the cytokine-induced expression of fascin in cancer cells.
fascin-1 is principally expressed in neural and mesenchymal derivatives during embryonic development
We propose that fascin is a key specific actin cross-linker, providing stiffness for filopodial bundles, and that its dynamic behavior allows for efficient coordination between elongation and bundling of filopodial actin filaments.
Fascin is a novel target of beta-catenin (show CTNNB1 Antibodies)-TCF (show HNF4A Antibodies) signaling and is expressed at the invasive front of human colon cancer
Fascin mRNA & protein levels were significantly lower in the cultured ANXA2 (show ANXA2 Antibodies)(-/-) cells than in cultured ANXA2 (show ANXA2 Antibodies)(+/+) cells. ANXA2 (show ANXA2 Antibodies) may be an inducer or enhancer of fascin expression at the transcription level.
These results suggest that strong positive fascin-1 expression can be used as a diagnostic marker of TNBC.
Authors demonstrated that one miRNA, miR (show MLXIP Antibodies)-29a-5p, can bind to both the XIAP (show XIAP Antibodies) and FSCN1 3'UTRs and play an important role in that interactions. We showed that the 3'UTR (show UTS2R Antibodies) of XIAP (show XIAP Antibodies) was able to antagonize miR (show MLXIP Antibodies)-29a-5p, and resulted in the increased translation of XIAP (show XIAP Antibodies) and FSCN1.
The expression of fascin-1 and lanminin-5 and the serum levels of fascin-1 and laminin-5 were related to the relapse of patients with non-small cell lung cancer.
The results uncover a role for fascin that operates independently of filopodia assembly to promote efficient cell migration and invasion.
FSCN1 is a direct target of miR (show MLXIP Antibodies)-539.MiR (show MLXIP Antibodies)-539 inhibits FSCN1 expression and suppresses hepatocellular carcinoma migration and invasion.
we show for the first time that HTLV-1 usurps the host cell factor Fascin to foster virus release and cell-to-cell transmission.
Results show that BMI1 (show BMI1 Antibodies) and FSCN1 are highly expressed in colorectal neoplasm and correlate with poor prognosis.
miR (show MLXIP Antibodies)-200b serves a suppressive role in the mediation of NSCLC cell migration and invasion, partly at least, via targeting FSCN1.
LRIG1 (show Lrig1 Antibodies) and Fascin-1 were differently expressed in cancer and normal lung tissue in patients with NSCLC, which could be a biomarker for mediastinal lymph node metastasis in NSCLC patients.
The increase in fascin1 expression may be the key point of this impact of TGF-beta1 (show TGFB1 Antibodies).
FSCN1 gene plays an in prenatal skeletal muscle development and was a candidate gene for meat production trait.
This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15.
, fascin 1
, singed-like protein
, 55 kDa actin-bundling protein
, singed-like (fascin homolog, sea urchin)