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FSCN1 encodes a member of the fascin family of actin-binding proteins. Additionally we are shipping Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) Antibodies (214) and Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) Proteins (18) and many more products for this protein.
Showing 10 out of 28 products:
Human FSCN1 ELISA Kit for Sandwich ELISA - ABIN414808
Teng, Xu, Yue, Ma, Zhang, Zhao, Guo, Zhang, Gu, Wang: Serological investigation of the clinical significance of fascin in non-small-cell lung cancer. in Lung cancer (Amsterdam, Netherlands) 2013
Alterations in nuclear Fascin levels result in defects in nucleolar morphology in both Drosophila follicles and cultured mammalian cells, suggesting that nuclear Fascin plays an important role in nucleolar architecture.
essential for actin bundle initiation and stiffening during embryonic tracheal system development
Fascin and Ena cooperate to extend and maintain robust filopodia of uniform thickness with aligned barbed ends by a unique mechanistic cycle.
Fascin links Btl/FGFR signalling to the actin cytoskeleton during Drosophila tracheal morphogenesis.
These data lead to the conclusion that prostaglandins regulate Fascin to control actin remodeling
The terminal branchlets of different classes of neurons have distinctive dynamics and are formed on the basis of molecularly separable mechanisms; in particular, class III neurons require fascin for terminal branching whereas class IV neurons do not.
The regulatory role of FascinS52 appears to be tissuespecific, and its importance might depend on the dynamics and the turnover rate of actin bundles between various cell types.
Fascin deficiency does not impair 20-hydroxyecdysone response, but neurites fail to maintain their normal, nearly straight trajectory, instead forming curls and hooks. This is accompanied by abnormally distributed filamentous actin.
Fascin is required for plasmatocyte migration, both as these cells undergo developmental dispersal and during an inflammatory response to epithelial wounding.
study found that Rab35 (show RAB35 ELISA Kits) regulates the assembly of actin (show ACTB ELISA Kits) filaments during bristle development; effect was mediated by the a (show ACTB ELISA Kits)ctin-bundling protein fascin, which directly associated with active R (show RAB35 ELISA Kits)ab35
These data show that fscn1a-dependent filopodia are required in a subset of NC cells to promote cell migration and NC derivative formation
Fascin-1 expression, cadherin-17 expression, tumor size, and differentiation were independent risk factors for GC.
Fascin1 facilitates phagolysosomal fusion for killing of phagocytosed Listeria. It binds to LC3 (show MAP1LC3A ELISA Kits), an autophagosome marker, both in vivo & in vitro. It plays a critical role in dendritic cell survivalduring Listeria infection.
A tightly regulated phospho/dephospho-fascin cycle modulated by extracellular signals is required for the polarized morphology and migration in neuroblasts, thus contributing to efficient neurogenesis.
fascin 1 promotes cell migration and has a role in growth and cell cycle progression
Suppression of fascin expression results in reduction of activation-induced migration and invasion in mouse monocytic leukemia (show KAT6B ELISA Kits) RAW264.7 macrophages.
Both STAT3 (show STAT3 ELISA Kits) and NFkappaB are required for the cytokine-induced expression of fascin in cancer cells.
fascin-1 is principally expressed in neural and mesenchymal derivatives during embryonic development
We propose that fascin is a key specific actin cross-linker, providing stiffness for filopodial bundles, and that its dynamic behavior allows for efficient coordination between elongation and bundling of filopodial actin filaments.
Fascin is a novel target of beta-catenin (show CTNNB1 ELISA Kits)-TCF (show HNF4A ELISA Kits) signaling and is expressed at the invasive front of human colon cancer
Fascin mRNA & protein levels were significantly lower in the cultured ANXA2 (show ANXA2 ELISA Kits)(-/-) cells than in cultured ANXA2 (show ANXA2 ELISA Kits)(+/+) cells. ANXA2 (show ANXA2 ELISA Kits) may be an inducer or enhancer of fascin expression at the transcription level.
Authors demonstrated that one miRNA, miR (show MLXIP ELISA Kits)-29a-5p, can bind to both the XIAP (show XIAP ELISA Kits) and FSCN1 3'UTRs and play an important role in that interactions. We showed that the 3'UTR (show UTS2R ELISA Kits) of XIAP (show XIAP ELISA Kits) was able to antagonize miR (show MLXIP ELISA Kits)-29a-5p, and resulted in the increased translation of XIAP (show XIAP ELISA Kits) and FSCN1.
The expression of fascin-1 and lanminin-5 and the serum levels of fascin-1 and laminin-5 were related to the relapse of patients with non-small cell lung cancer.
The results uncover a role for fascin that operates independently of filopodia assembly to promote efficient cell migration and invasion.
FSCN1 is a direct target of miR (show MLXIP ELISA Kits)-539.MiR (show MLXIP ELISA Kits)-539 inhibits FSCN1 expression and suppresses hepatocellular carcinoma migration and invasion.
we show for the first time that HTLV-1 usurps the host cell factor Fascin to foster virus release and cell-to-cell transmission.
Results show that BMI1 (show BMI1 ELISA Kits) and FSCN1 are highly expressed in colorectal neoplasm and correlate with poor prognosis.
miR (show MLXIP ELISA Kits)-200b serves a suppressive role in the mediation of NSCLC cell migration and invasion, partly at least, via targeting FSCN1.
LRIG1 (show Lrig1 ELISA Kits) and Fascin-1 were differently expressed in cancer and normal lung tissue in patients with NSCLC, which could be a biomarker for mediastinal lymph node metastasis in NSCLC patients.
The increase in fascin1 expression may be the key point of this impact of TGF-beta1 (show TGFB1 ELISA Kits).
Fascin 1 plays an oncogenic role in non-small cell lung cancer
FSCN1 gene plays an in prenatal skeletal muscle development and was a candidate gene for meat production trait.
This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15.
, fascin 1
, singed-like protein
, 55 kDa actin-bundling protein
, singed-like (fascin homolog, sea urchin)