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FTO is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of FTO is not known. Additionally we are shipping FTO Antibodies (140) and FTO Kits (9) and many more products for this protein.
Showing 9 out of 11 products:
importance of determining FTO, 9p21, and 2q36.3 variants as part of the genetic determination of myocardial infarction risk in the Czech male population
This study showed that the AA genotype of FTO rs9939609 seems to be associated with a higher risk of CVD.
FTO expression may have a vital role in the carcinogenesis of breast cancer
Our results demonstrate that FTO gene has little association in polycystic ovary syndrome development.
Physical activity may modify the genetic effect of FTO on the obesity-related risk in Latino children and adults.
FTO is a ubiquitously expressed N6-methyladenosine demethylase
Meta-analysis indicates that SNP rs9939609 within FTO is not associated with major depressive disorder (MDD) in Asian population.
Higher levels of growth hormone (show GH1 Proteins) in lean women carrying the FTO haplotype protected them from the development of obesity.
A significant additive effect on BMI values was found in males with certain genetic variants in FTO genes.
The present study suggested that GSTM1 (show GSTM1 Proteins), GSTT1 (show GSTT1 Proteins) and FTO gene polymorphisms are associated with increased risk for cataract in North Indian populations.
Taken together, the results suggest that Fto regulates the proliferation and differentiation of 3T3-L1 cells via multiple mechanisms, including PPARgamma (show PPARG Proteins) and PI3K/Akt (show AKT1 Proteins) signaling.
These results reveal that FTO regulates fatty acid mobilization in adipocytes and thus body weight in part through posttranscriptional regulation of Angptl4 (show ANGPTL4 Proteins).
FTO-dependent N6-methyladenosine demethylation may be affected by betaine.
FTO modulates circadian rhythms and inhibits the CLOCK-BMAL1 (show ARNTL Proteins)-induced transcription.
FTO expression and N6-methyladenosine levels are inversely correlated during adipogenesis. FTO depletion blocks differentiation and only catalytically active FTO restores adipogenesis.
FTO is present in both the nucleus and cytoplasm, with a mobile fraction that shuttles between both cellular compartments, possibly by interaction with XPO2 (show CSE1L Proteins).
FTO plays an important role in the development of metabolic disorders and is an interesting target for therapeutic agents.
data suggest that IRX3 (show IRX3 Proteins) is a functional long-range target of obesity-associated variants within FTO and represents a novel determinant of body mass and composition
FTO silencing did not modify PPARgamma2 (show PPARG Proteins) mRNA levels. Partial reduction of FTO did not influence the first step of 3T3-L1 adipocyte differentiation.
Downregulation was seen only with essential amino-acid deficiency and not with non-essential amino acids. These data suggest that FTO might have a role in the sensing of essential amino-acid availability.
In this study, the authors characterise the nucleotide variability and haplotype diversity of the porcine fat mass and obesity-associated (FTO) gene in breeds having different predispositions to fat deposition traits.
In pig, the FTO gene influences back fat depth in the commercial populations.
This study will provide clues for obtaining a better understanding of the porcine FTO gene function.
The results of the association analyses confirmed the effect of the FTO mutation on obesity-related traits in the Italian Duroc pigs (P < 0.01) and in the commercial pigs.
The porcine fat mass and obesity associated (FTO) gene is associated with fat deposition in Italian Duroc pigs.
34 FTO polymorphisms revealed significant association of FTO variants with lean meat percentage in Simmental and Brown cattle breeds.
association signals not only provided evidence for at least two causative mutations in the FTO locus with a functional effect on milk but also milk protein (show CSN2 Proteins) yield
Haplotype frequencies and linkage disequilibrium (LD) coefficients of FTO single nucleotide polymorphisms in three Chinese indigenous cattle breeds were analyzed.
This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes.
alpha-ketoglutarate-dependent dioxygenase FTO
, fat mass and obesity-associated protein
, protein fto
, protein fatso
, fat mass and obesity associated protein
, Protein fatso