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Fat Mass and Obesity-Associated Proteins (FTO)

FTO is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of FTO is not known. Additionally we are shipping FTO Antibodies (143) and FTO Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FTO 79068 Q9C0B1
FTO 26383 Q8BGW1
FTO 291905 Q2A121
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Top FTO Proteins at antibodies-online.com

Showing 7 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag   10 μg Log in to see 2 to 3 Days
$262.50
Details
HOST_Escherichia coli (E. coli) Human His tag   10 μg Log in to see 2 to 3 Days
$262.50
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,424.67
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

FTO Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Fat Mass and Obesity-Associated (FTO) Interaction Partners

Human Fat Mass and Obesity-Associated (FTO) interaction partners

  1. FTO rs9939609, MC4R (show MC4R Proteins) rs17782313, and PPARgamma (show PPARG Proteins) rs1801282 polymorphisms seem to have little effect on the incidence of metabolic malfunctions and no effect on androgen-related disorders in the examined middle-aged and elderly men.

  2. Mothers' FTO rs9939609 and LEPR rs1137101 gene polymorphisms presented an impact on birth weight and newborns' BMI, therefore being involved in the newborns' nutritional status and in the design of a potential protocol.

  3. The FTO gene in Turkish adults contributes independently to obesity in women and-by interacting with BMI-to MetS (show ETV3 Proteins) and insulin (show INS Proteins) resistance in men.

  4. This is the first study to reveal that genetic variants of both FTO and IRX3 genes are in high linkage disequilibrium (LD) and are associated with obesity risk in North Indians.

  5. Our study suggests that FTO exerts its effect on BMI, at least partly, through energy expenditure mechanisms such as TSS (show RPL38 Proteins). Further research into the intersection of genetics, sedentary behavior and obesity-related outcomes is warranted.

  6. results show no difference in allele frequencies between bipolar cases and controls and we conclude that there is no evidence that FTO variants affect susceptibility to affective disorder

  7. These data suggest that biological aging in men may be accelerated by increasing waist circumference, whereas in women, aging may be affected by genetic variations in FTO regardless of adiposity changes over time.

  8. In the study population of South Asian ancestry, variants of the FTO gene predispose to type 2 diabetes, but not entirely through their effect on BMI.

  9. Results show that FTO was overexpressed in endometrial carcinoma tissues and its expression correlated with poor prognostic. Additionally, estrogen induced FTO nuclear accumulation via the mTOR (show FRAP1 Proteins) signaling pathway and the nuclear localization was ERalpha (show ESR1 Proteins)-dependent, which contributed to enhanced proliferative activity.

  10. that the FTO rs9939609 and MC4R rs17782313 variants may be significantly associated with nocturnal but not daytime blood pressure levels and their combined effects were significant in this Chinese Han population

Mouse (Murine) Fat Mass and Obesity-Associated (FTO) interaction partners

  1. Here we show that FTO expression is increased after ureteral obstruction and renal fibrosis.

  2. Taken together, the results suggest that Fto regulates the proliferation and differentiation of 3T3-L1 cells via multiple mechanisms, including PPARgamma (show PPARG Proteins) and PI3K/Akt (show AKT1 Proteins) signaling.

  3. These results reveal that FTO regulates fatty acid mobilization in adipocytes and thus body weight in part through posttranscriptional regulation of Angptl4 (show ANGPTL4 Proteins).

  4. FTO-dependent N6-methyladenosine demethylation may be affected by betaine.

  5. FTO modulates circadian rhythms and inhibits the CLOCK-BMAL1 (show ARNTL Proteins)-induced transcription.

  6. FTO expression and N6-methyladenosine levels are inversely correlated during adipogenesis. FTO depletion blocks differentiation and only catalytically active FTO restores adipogenesis.

  7. FTO is present in both the nucleus and cytoplasm, with a mobile fraction that shuttles between both cellular compartments, possibly by interaction with XPO2 (show CSE1L Proteins).

  8. FTO plays an important role in the development of metabolic disorders and is an interesting target for therapeutic agents.

  9. data suggest that IRX3 (show IRX3 Proteins) is a functional long-range target of obesity-associated variants within FTO and represents a novel determinant of body mass and composition

  10. FTO silencing did not modify PPARgamma2 (show PPARG Proteins) mRNA levels. Partial reduction of FTO did not influence the first step of 3T3-L1 adipocyte differentiation.

Pig (Porcine) Fat Mass and Obesity-Associated (FTO) interaction partners

  1. In this study, the authors characterise the nucleotide variability and haplotype diversity of the porcine fat mass and obesity-associated (FTO) gene in breeds having different predispositions to fat deposition traits.

  2. In pig, the FTO gene influences back fat depth in the commercial populations.

  3. This study will provide clues for obtaining a better understanding of the porcine FTO gene function.

  4. The results of the association analyses confirmed the effect of the FTO mutation on obesity-related traits in the Italian Duroc pigs (P < 0.01) and in the commercial pigs.

  5. The porcine fat mass and obesity associated (FTO) gene is associated with fat deposition in Italian Duroc pigs.

Cow (Bovine) Fat Mass and Obesity-Associated (FTO) interaction partners

  1. 34 FTO polymorphisms revealed significant association of FTO variants with lean meat percentage in Simmental and Brown cattle breeds.

  2. association signals not only provided evidence for at least two causative mutations in the FTO locus with a functional effect on milk but also milk protein (show CSN2 Proteins) yield

  3. Haplotype frequencies and linkage disequilibrium (LD) coefficients of FTO single nucleotide polymorphisms in three Chinese indigenous cattle breeds were analyzed.

FTO Protein Profile

Protein Summary

This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes.

Gene names and symbols associated with FTO

  • fat mass and obesity associated (FTO)
  • fat mass and obesity associated (Fto)
  • fat mass and obesity associated (fto)
  • AW743446 protein
  • mKIAA1752 protein
  • RGD1305121 protein

Protein level used designations for FTO

alpha-ketoglutarate-dependent dioxygenase FTO , fat mass and obesity-associated protein , protein fto , protein fatso , fat mass and obesity associated protein , Protein fatso

GENE ID SPECIES
79068 Homo sapiens
26383 Mus musculus
478125 Canis lupus familiaris
100127165 Sus scrofa
291905 Rattus norvegicus
100060565 Equus caballus
618622 Bos taurus
100125353 Ovis aries
447305 Xenopus laevis
100173222 Pongo abelii
Selected quality suppliers for FTO Proteins (FTO)
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