anti-Fat Mass and Obesity-Associated (FTO) Antibodies

FTO is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of FTO is not known. Additionally we are shipping FTO Kits (10) and FTO Proteins (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
FTO 79068 Q9C0B1
FTO 26383 Q8BGW1
FTO 291905 Q2A121
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Top anti-FTO Antibodies at antibodies-online.com

Showing 10 out of 142 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of FTO Antibody (N-term) in NCI-H460 cell line lysates (35 µg/lane). FTO (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of FTO Antibody (N-term) (ABIN390964) in NCI-H460 cell line lysates (35 µg/lane). FTO (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with FTO Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated ELISA, WB ABIN308414 (0.03µg/ml) staining of Human Pancreas lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$326.89
Details
Human Rabbit Un-conjugated WB Detection of FTO in human brain lysate using ABIN258809. 0.1 mL Log in to see 7 to 9 Days
$408.19
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Fto Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Mouse Brain WB Suggested Anti-Fto  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500  Positive Control: Mouse Brain 100 μL Log in to see 2 to 3 Days
$289.00
Details
Dog Rabbit Un-conjugated WB WB Suggested Anti-FTO Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: PANC1 cell lysate WB Suggested Anti-FTO  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500  Positive Control: PANC1 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA, WB Western Blot: FTO Antibody [NBP1-05039] - (0.03ug/ml) Analysis of Human Pancreas lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 7 to 9 Days
$408.19
Details
Human Rabbit Un-conjugated FACS, IHC, WB 100 μL Log in to see 2 to 3 Days
$245.00
Details
Dog Goat Un-conjugated WB   0.1 mg Log in to see 12 to 15 Days
$375.38
Details
Cow Mouse Un-conjugated IF, IHC (p), WB   0.1 mL Log in to see 20 Days
$375.38
Details

FTO Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-FTO Antibodies

  1. Human Polyclonal FTO Primary Antibody for ELISA, WB - ABIN316349 : Gerken, Girard, Tung, Webby, Saudek, Hewitson, Yeo, McDonough, Cunliffe, McNeill, Galvanovskis, Rorsman, Robins, Prieur, Coll, Ma, Jovanovic, Farooqi, Sedgwick, Barroso, Lindahl, Ponting, Ashcroft et al.: The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. ... in Science (New York, N.Y.) 2007 (PubMed)

  2. Human Polyclonal FTO Primary Antibody for EIA, WB - ABIN453035 : Scott, Mohlke, Bonnycastle, Willer, Li, Duren, Erdos, Stringham, Chines, Jackson, Prokunina-Olsson, Ding, Swift, Narisu, Hu, Pruim, Xiao, Li, Conneely, Riebow, Sprau, Tong, White, Hetrick, Barnhart, Bark, Goldstein, Watkins, Xiang, Saramies, Buchanan, Wat: A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. in Science (New York, N.Y.) 2007 (PubMed)

  3. Human Polyclonal FTO Primary Antibody for WB - ABIN258809 : Walters, Mercaldo, Gillon, Yip, Neve, Boyce, Frankland, Josselyn: The Role of The RNA Demethylase FTO (Fat Mass and Obesity-Associated) and mRNA Methylation in Hippocampal Memory Formation. in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2017 (PubMed)

More Antibodies against FTO Interaction Partners

Human Fat Mass and Obesity-Associated (FTO) interaction partners

  1. data reveal that genetic variation in FTO alpha-ketoglutarate dependent dioxygenase impacts on body weight reduction during lifestyle intervention only in subjects with marked improvement in aerobic fitness

  2. In a large all-adult and area-based population survey the effects of obesity-promoting minor-alleles of FTO and MCR4, and interactions with life style factors are age- and gender-related

  3. we performed a candidate-gene association study in a young and sportive Italian population by testing the association of functional polymorphisms in ACE (show ACE Antibodies) (rs4646994), FTO (rs9939609), MC4R (show MC4R Antibodies) (rs17782313) and PPARG (show PPARG Antibodies) (rs1801282) genes with body mass index (BMI) and waist-to-height ratio (WHtR).

  4. This meta-analysis suggests that rs9939609 A/T polymorphism of FTO gene is associated with polycystic ovary syndrome risk, and that A allele is a risk factor for polycystic ovary syndrome susceptibility simultaneously. [Review; meta-analysis]

  5. the enzymatic activity of FTO

  6. The effects of variations in FTO are dependent on dopamine D2 receptor (show DRD2 Antibodies) density (determined by the ANKK1 (show ANKK1 Antibodies) polymorphism). Carriers of both risk alleles might, therefore, be at increased risk of obesity and diabetes.

  7. the FTO rs9939609 SNP was found to influence the relationship between these variables, as an association between disorder of corporeality and emotional eating was found only in A-allele carriers. A-allele seems to represent a potential additive risk factor for EDs persons, with bodily disorders to develop emotional eating and binge eating behaviors.

  8. The FTO gene polymorphisms rs9939609 and rs17817449 play a role in the in the development of insulin (show INS Antibodies) resistance and hence occurrence of type 2 dabetes mellitus in obese patients.

  9. Study found that in a Korean cohort, the FTO rs9939609 polymorphism is an independent risk factor for obesity and also for biological aging in the nonobese population.

  10. Genetic clues to the mechanism by which MC4R, FTO, and NMB influences changes in BMI and obesity.

Mouse (Murine) Fat Mass and Obesity-Associated (FTO) interaction partners

  1. the results of this study indicate that the effects of FTO-associated SNPs on energy homeostasis are due in part to the effects of these genetic variations on hypothalamic FTO, RPGRIP1L (show RPGRIP1L Antibodies), and possibly other genes.

  2. FTO may have a deleterious role in hepatic cells during lipotoxic conditions, and up-regulation of FTO may contribute to the increased liver damage in non-alcoholic steatohepatitis

  3. Fto deficiency affects the gene and miR130/miR378 expression involved in brown adipogenesis and browning of white adipose tissue in mice.

  4. Here we show that FTO expression is increased after ureteral obstruction and renal fibrosis.

  5. Taken together, the results suggest that Fto regulates the proliferation and differentiation of 3T3-L1 cells via multiple mechanisms, including PPARgamma (show PPARG Antibodies) and PI3K/Akt (show AKT1 Antibodies) signaling.

  6. These results reveal that FTO regulates fatty acid mobilization in adipocytes and thus body weight in part through posttranscriptional regulation of Angptl4 (show ANGPTL4 Antibodies).

  7. FTO-dependent N6-methyladenosine demethylation may be affected by betaine.

  8. FTO modulates circadian rhythms and inhibits the CLOCK-BMAL1 (show ARNTL Antibodies)-induced transcription.

  9. FTO expression and N6-methyladenosine levels are inversely correlated during adipogenesis. FTO depletion blocks differentiation and only catalytically active FTO restores adipogenesis.

  10. FTO is present in both the nucleus and cytoplasm, with a mobile fraction that shuttles between both cellular compartments, possibly by interaction with XPO2 (show CSE1L Antibodies).

Pig (Porcine) Fat Mass and Obesity-Associated (FTO) interaction partners

  1. In this study, the authors characterise the nucleotide variability and haplotype diversity of the porcine fat mass and obesity-associated (FTO) gene in breeds having different predispositions to fat deposition traits.

  2. In pig, the FTO gene influences back fat depth in the commercial populations.

  3. This study will provide clues for obtaining a better understanding of the porcine FTO gene function.

  4. The results of the association analyses confirmed the effect of the FTO mutation on obesity-related traits in the Italian Duroc pigs (P < 0.01) and in the commercial pigs.

  5. The porcine fat mass and obesity associated (FTO) gene is associated with fat deposition in Italian Duroc pigs.

Cow (Bovine) Fat Mass and Obesity-Associated (FTO) interaction partners

  1. 34 FTO polymorphisms revealed significant association of FTO variants with lean meat percentage in Simmental and Brown cattle breeds.

  2. association signals not only provided evidence for at least two causative mutations in the FTO locus with a functional effect on milk but also milk protein (show CSN2 Antibodies) yield

  3. Haplotype frequencies and linkage disequilibrium (LD) coefficients of FTO single nucleotide polymorphisms in three Chinese indigenous cattle breeds were analyzed.

FTO Antigen Profile

Protein Summary

This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes.

Gene names and symbols associated with FTO

  • fat mass and obesity associated (FTO) antibody
  • fat mass and obesity associated (Fto) antibody
  • fat mass and obesity associated (fto) antibody
  • AW743446 antibody
  • mKIAA1752 antibody
  • RGD1305121 antibody

Protein level used designations for FTO

alpha-ketoglutarate-dependent dioxygenase FTO , fat mass and obesity-associated protein , protein fto , protein fatso , fat mass and obesity associated protein , Protein fatso

GENE ID SPECIES
79068 Homo sapiens
26383 Mus musculus
478125 Canis lupus familiaris
100127165 Sus scrofa
291905 Rattus norvegicus
100060565 Equus caballus
618622 Bos taurus
100125353 Ovis aries
447305 Xenopus laevis
100173222 Pongo abelii
Selected quality suppliers for anti-FTO (FTO) Antibodies
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