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anti-Fat Mass and Obesity-Associated (FTO) Antibodies

FTO is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of FTO is not known. Additionally we are shipping FTO Proteins (10) and FTO Kits (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
FTO 79068 Q9C0B1
FTO 26383 Q8BGW1
FTO 291905 Q2A121
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Top anti-FTO Antibodies at antibodies-online.com

Showing 10 out of 139 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of FTO Antibody (N-term) in NCI-H460 cell line lysates (35 µg/lane). FTO (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Cow Mouse Un-conjugated IF, IHC (p), WB 0.1 mL Log in to see 6 to 8 Days
$445.50
Details
Dog Goat Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of FTO Antibody (N-term) (ABIN390964) in NCI-H460 cell line lysates (35 µg/lane). FTO (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with FTO Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated ELISA, WB ABIN308414 (0.03µg/ml) staining of Human Pancreas lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$326.89
Details
Dog Rabbit Un-conjugated WB WB Suggested Anti-FTO Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: PANC1 cell lysate WB Suggested Anti-FTO  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500  Positive Control: PANC1 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Fto Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Mouse Brain WB Suggested Anti-Fto  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500  Positive Control: Mouse Brain 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry of FTO in mouse brain tissue with FTO antibody at 2.5 μg/ml. Western blot analysis of FTO in human uterus tissue lysate with AP30350PU-N FTO antibody at (A) 1 and (B) 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Goat Un-conjugated ELISA, WB Western Blot: FTO Antibody [NBP1-05039] - (0.03ug/ml) Analysis of Human Pancreas lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 7 to 9 Days
$408.19
Details
Human Rabbit Un-conjugated FACS, IHC, WB 100 μL Log in to see 2 to 3 Days
$283.50
Details

FTO Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-FTO Antibodies

  1. Human Polyclonal FTO Primary Antibody for EIA, IHC (p) - ABIN499863 : Scuteri, Sanna, Chen, Uda, Albai, Strait, Najjar, Nagaraja, Orrú, Usala, Dei, Lai, Maschio, Busonero, Mulas, Ehret, Fink, Weder, Cooper, Galan, Chakravarti, Schlessinger, Cao, Lakatta, Abecasis: Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. in PLoS genetics 2008 (PubMed)

  2. Human Polyclonal FTO Primary Antibody for ELISA, WB - ABIN316349 : Gerken, Girard, Tung, Webby, Saudek, Hewitson, Yeo, McDonough, Cunliffe, McNeill, Galvanovskis, Rorsman, Robins, Prieur, Coll, Ma, Jovanovic, Farooqi, Sedgwick, Barroso, Lindahl, Ponting, Ashcroft et al.: The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. ... in Science (New York, N.Y.) 2007 (PubMed)

  3. Human Polyclonal FTO Primary Antibody for EIA, WB - ABIN453035 : Scott, Mohlke, Bonnycastle, Willer, Li, Duren, Erdos, Stringham, Chines, Jackson, Prokunina-Olsson, Ding, Swift, Narisu, Hu, Pruim, Xiao, Li, Conneely, Riebow, Sprau, Tong, White, Hetrick, Barnhart, Bark, Goldstein, Watkins, Xiang, Saramies, Buchanan, Wat: A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. in Science (New York, N.Y.) 2007 (PubMed)

  4. Cow (Bovine) Monoclonal FTO Primary Antibody for IF, IHC (p) - ABIN782440 : Fredriksson, Hägglund, Olszewski, Stephansson, Jacobsson, Olszewska, Levine, Lindblom, Schiöth: The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain. in Endocrinology 2008 (PubMed)

More Antibodies against FTO Interaction Partners

Human Fat Mass and Obesity-Associated (FTO) interaction partners

  1. This is the first report showing evidence of FTO and ABCA1 (show ABCA1 Antibodies) gene variant interactions affecting BMI, which may explain previously reported population differences

  2. FTO enhances leukemic oncogene (show RAB1A Antibodies)-mediated cell transformation and leukemogenesis, and inhibits all-trans-retinoic acid (ATRA)-induced AML (show RUNX1 Antibodies) cell differentiation, through regulating expression of targets such as ASB2 (show ASB2 Antibodies) and RARA (show RARA Antibodies) by reducing m(6)A levels in these mRNA transcripts.

  3. We find robust evidence of interaction with physical activity for the strongest known obesity risk-locus in the FTO gene, of which the body mass index-increasing effect is attenuated by ~30% in physically active individuals compared to inactive individuals.

  4. FTO may have a deleterious role in hepatic cells during lipotoxic conditions, and up-regulation of FTO may contribute to the increased liver damage in non-alcoholic steatohepatitis

  5. An FTO genetic variant was found to be associated with reduced semen quality.

  6. We confirmed associations with papillary thyroid cancer and SNPs in FOXE1 (show FOXE1 Antibodies)/HEMGN, SERPINA5 (show SERPINA5 Antibodies) (rs2069974), FTO (rs8047395), EVPL (show EVPL Antibodies) (rs2071194), TICAM1 (show TICAM1 Antibodies) (rs8120) and SCARB1 (show SCARB1 Antibodies) (rs11057820) genes. We found associations with SNPs in FOXE1 (show FOXE1 Antibodies), SERPINA5 (show SERPINA5 Antibodies), FTO, TICAM1 (show TICAM1 Antibodies) and HSPA6 (show HSPA6 Antibodies) and and follicular thyroid cancer

  7. the association between FTO and obesity appears to be due to its influence on expression of IRX3 [Figure 1]. Genetic studies indicated FTO as an important gene for obesity risk in various populations but the recent developments suggest that obesity-associated FTO SNPs have long-range interactions with IRX3.

  8. This study shows that FTO rs9939506 GG genotype is related to higher BMI and is associated with obesity in Polish adults.

  9. Case Report: MC4R (show MC4R Antibodies) p.Met215del coexisting with FTO and MC1R (show MSHR Antibodies) gene variants, causes severe early onset obesity.

  10. The FTO rs9939609 polymorphism was associated with anthropometric parameters and metabolic syndrome in the younger age group (25-44 years) and in individuals having low level of physical activity.

Mouse (Murine) Fat Mass and Obesity-Associated (FTO) interaction partners

  1. FTO may have a deleterious role in hepatic cells during lipotoxic conditions, and up-regulation of FTO may contribute to the increased liver damage in non-alcoholic steatohepatitis

  2. Fto deficiency affects the gene and miR130/miR378 expression involved in brown adipogenesis and browning of white adipose tissue in mice.

  3. Here we show that FTO expression is increased after ureteral obstruction and renal fibrosis.

  4. Taken together, the results suggest that Fto regulates the proliferation and differentiation of 3T3-L1 cells via multiple mechanisms, including PPARgamma (show PPARG Antibodies) and PI3K/Akt (show AKT1 Antibodies) signaling.

  5. These results reveal that FTO regulates fatty acid mobilization in adipocytes and thus body weight in part through posttranscriptional regulation of Angptl4 (show ANGPTL4 Antibodies).

  6. FTO-dependent N6-methyladenosine demethylation may be affected by betaine.

  7. FTO modulates circadian rhythms and inhibits the CLOCK-BMAL1 (show ARNTL Antibodies)-induced transcription.

  8. FTO expression and N6-methyladenosine levels are inversely correlated during adipogenesis. FTO depletion blocks differentiation and only catalytically active FTO restores adipogenesis.

  9. FTO is present in both the nucleus and cytoplasm, with a mobile fraction that shuttles between both cellular compartments, possibly by interaction with XPO2 (show CSE1L Antibodies).

  10. FTO plays an important role in the development of metabolic disorders and is an interesting target for therapeutic agents.

Pig (Porcine) Fat Mass and Obesity-Associated (FTO) interaction partners

  1. In this study, the authors characterise the nucleotide variability and haplotype diversity of the porcine fat mass and obesity-associated (FTO) gene in breeds having different predispositions to fat deposition traits.

  2. In pig, the FTO gene influences back fat depth in the commercial populations.

  3. This study will provide clues for obtaining a better understanding of the porcine FTO gene function.

  4. The results of the association analyses confirmed the effect of the FTO mutation on obesity-related traits in the Italian Duroc pigs (P < 0.01) and in the commercial pigs.

  5. The porcine fat mass and obesity associated (FTO) gene is associated with fat deposition in Italian Duroc pigs.

Cow (Bovine) Fat Mass and Obesity-Associated (FTO) interaction partners

  1. 34 FTO polymorphisms revealed significant association of FTO variants with lean meat percentage in Simmental and Brown cattle breeds.

  2. association signals not only provided evidence for at least two causative mutations in the FTO locus with a functional effect on milk but also milk protein (show CSN2 Antibodies) yield

  3. Haplotype frequencies and linkage disequilibrium (LD) coefficients of FTO single nucleotide polymorphisms in three Chinese indigenous cattle breeds were analyzed.

FTO Antigen Profile

Protein Summary

This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes.

Gene names and symbols associated with FTO

  • fat mass and obesity associated (FTO) antibody
  • fat mass and obesity associated (Fto) antibody
  • fat mass and obesity associated (fto) antibody
  • AW743446 antibody
  • mKIAA1752 antibody
  • RGD1305121 antibody

Protein level used designations for FTO

alpha-ketoglutarate-dependent dioxygenase FTO , fat mass and obesity-associated protein , protein fto , protein fatso , fat mass and obesity associated protein , Protein fatso

GENE ID SPECIES
79068 Homo sapiens
26383 Mus musculus
478125 Canis lupus familiaris
100127165 Sus scrofa
291905 Rattus norvegicus
100060565 Equus caballus
618622 Bos taurus
100125353 Ovis aries
447305 Xenopus laevis
100173222 Pongo abelii
Selected quality suppliers for anti-FTO (FTO) Antibodies
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