Fatty Acid Desaturase 2 Proteins (FADS2)

The protein encoded by FADS2 is a member of the fatty acid desaturase (FADS) gene family. Additionally we are shipping FADS2 Antibodies (49) and FADS2 Kits (25) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FADS2 56473 Q9Z0R9
FADS2 9415 O95864
Rat FADS2 FADS2 83512 Q9Z122
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Top FADS2 Proteins at antibodies-online.com

Showing 7 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$6,041.49
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Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Escherichia coli (E. coli) Human T7 tag,His tag   100 μg Log in to see 15 to 18 Days
$704.00
Details

FADS2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
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Human , , ,
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More Proteins for Fatty Acid Desaturase 2 (FADS2) Interaction Partners

Zebrafish Fatty Acid Desaturase 2 (FADS2) interaction partners

  1. these results implicate that Z-FADS, the sole fatty acid desaturase (show SCD Proteins) ever been identified in zebrafish, can serve as a universal fatty acid desaturase (show SCD Proteins) during lipogenesis.

Mouse (Murine) Fatty Acid Desaturase 2 (FADS2) interaction partners

  1. Data (including data from studies using knockout mice) suggest that immunomodulatory effects of dietary omega-6 vs. omega-3 fatty acids are due, in part, to interconversion of the various unsaturated fatty acids consumed/administered; thus, delta-6 desaturase plays role in immunomodulatory effects of dietary unsaturated fatty acids.

  2. Using a sample of 534 twins, study observed a trend in the moderation of brain fatty acid effects on IQ by FADS2 variation. Using of publicly available gene expression databases from both humans and mice, showed that FADS2 variants also correlate with FADS1 (show FADS1 Proteins) brain expression

  3. differential PUFA profiles between HET mice and human FADS SNPs suggest low expression of both FADS1 (show FADS1 Proteins) and 2 genes in human minor haplotypes.

  4. FADS2 deficient mice are obesity resistant.

  5. knockdown of Elovl5, Fads1 (show FADS1 Proteins), or Fads2 decreased the level of Mead acid.

  6. D6D activity is upregulated during melanoma and lung tumor growth and that suppressing D6D activity, either by RNAi knockdown or a specific D6D inhibitor, dramatically reduces tumor growth.

  7. Results suggest that Fads2 is essential for spermatogenesis; Fads2-/- knockout mice develop docosahexaenoic acid deficiency and acrosome biogenesis is halted after release of proacrosomal granules.

  8. analysis of macrophage cholesterol biosynthesis and decreased cellular paraoxonase 2 (PON2 (show PON2 Proteins)) expression in Delta6-desaturase knockout (6-DS KO) mice

  9. We created D6D-null mice (-/-), which enabled us to study highly unsaturated fatty acid deficiency without depleting their precursors.

  10. methylation silencing of liver Fads2 expression and changes in liver fatty acids may contribute to the pathology of hyperhomocysteinemia.

Human Fatty Acid Desaturase 2 (FADS2) interaction partners

  1. Results show that preterm infants had as high D6D activity as term infants at birth. Thus, they have an ability to produce AA and DHA from precursor polyunsaturated fatty acids. After birth, D6D activity declined rapidly during first month.

  2. The majority of CpG sites (117 out of 136, 86%) exhibited high levels of methylation with the greatest variability observed at three key regulatory regions-the promoter regions for FADS1 (show FADS1 Proteins) and FADS2 and a putative enhancer site between the two genes.

  3. FADS1 (show FADS1 Proteins) rs174547 and FADS2 rs2727270 genotypes were significantly correlated with decreased HDL (show HSD11B1 Proteins)-C concentrations, and D5D (show FADS1 Proteins) /D6D activities as estimated as 20:4(n-6)/20:3 (n-6) and 18:3 (n-6)/18:2 (n-6) in a linear pattern in patients with type 2 diabetes

  4. Using a sample of 534 twins, study observed a trend in the moderation of brain fatty acid effects on IQ by FADS2 variation. Using of publicly available gene expression databases from both humans and mice, showed that FADS2 variants also correlate with FADS1 (show FADS1 Proteins) brain expression

  5. These data indicate that delta-6 desaturase activity might not be essential for the distinct effects of LA and ALA on NFkappaB activity.

  6. SNP (rs1535) and 2-locus haplotypes (rs3834458-rs1535, rs1535-rs174575) in the FADS2 gene were associated with concentrations of gamma-linoleic acid (GLA (show NAT8 Proteins)) and arachidonic acid (AA) in breast milk; the 3-locus haplotype rs3834458-rs1535-rs174575, significantly affected concentrations of GLA (show NAT8 Proteins) but not AA

  7. This study showed associations between FADS 1 (show FADS1 Proteins)/2 SNPs and cognitive performance. rs1535 minor allele homozygosity and rs174448 major allele carriage associated with improved cognitive performance in 8- to 11-y-old boys but not in girls, thereby counteracting existing sex differences.

  8. This study demonstrates for the first time that genetic variation in FADS2 is not only associated with the activity of the desaturation-elongation pathway, but also whole-body fat oxidation.

  9. Our results demonstrate that FADS1 (show FADS1 Proteins)-FADS2 are susceptibility genes for PCOS.

  10. Single nucleotide polymorphisms in FADS gene (particularly rs174537) associate with plasma fatty acids and desaturase levels in patients with both type 2 diabetes and coronary artery disease.

FADS2 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1\; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization.

Gene names and symbols associated with FADS2

  • fatty acid desaturase 2 (fads2)
  • fatty acid desaturase 2 (Fads2)
  • fatty acid desaturase 2 (FADS2)
  • 2900042M13Rik protein
  • D6D protein
  • DES6 protein
  • DRD5/D6 protein
  • Fadsd2 protein
  • FADSD6 protein
  • LLCDL2 protein
  • SLL0262 protein
  • TU13 protein
  • wu:fb64c04 protein
  • wu:fb69e08 protein
  • zgc:112502 protein

Protein level used designations for FADS2

D5D/D6D fatty acid desaturase , delta(5)/Delta(6) fatty acid desaturase , delta-5/Delta-6 fatty acid desaturase , delta-6 fatty acyl desaturase , D6D , delta(6) desaturase , delta(6) fatty acid desaturase , delta-6 desaturase , delta-6 fatty acid desaturase , delta-6-desaturase , linoleoyl-CoA desaturase (delta-6-desaturase)-like 2 , fatty acid desaturase 6

GENE ID SPECIES
140615 Danio rerio
56473 Mus musculus
9415 Homo sapiens
83512 Rattus norvegicus
521822 Bos taurus
423122 Gallus gallus
444997 Sus scrofa
100190814 Pongo abelii
446688 Xenopus laevis
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