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The protein encoded by FADS3 is a member of the fatty acid desaturase (FADS) gene family. Additionally we are shipping FADS3 Antibodies (41) and FADS3 Kits (11) and many more products for this protein.
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FADS3 does exist under multiple protein isoforms depending on the mammalian tissues.
pairwise comparison showed that individuals major homozygous for the SNP rs1000778 in the FADS3 gene had lower concentrations of a-linolenic acid and linoleic acid in their breast milk
Minor allele homozygotes and heterozygotes of rs174455 in FADS3 gene had lower levels of 22:5 omega-3, 20:4 omega-6, and Delta5desaturase activity in patients with type 2 diabetes mellitus.
Data suggest that FADS3 alternative transcripts/splicing are up-regulated in liver by dietary docosahexaenoic/arachidonic acids by peroxisome proliferator-activated receptor gamma (PPARg (show PPARG Proteins))-dependent mechanism unrelated to other desaturases (FADS1 (show FADS1 Proteins)/2).
genetic association study in maternal/child dyads in England: Data suggest that SNPs in FADS3 (and in FADS1/FADS2) influence fetal fatty acid metabolism; both maternal and child FADS genotypes/haplotypes influence cord plasma long-chain fatty acids.
it is highly likely that a gene product of FADS3 has desaturating activity.
USF1 (show USF1 Proteins) and FADS3 are causal candidate genes for the Mexican familial combined hyperlipidemia.
The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1\; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization.
fatty acid desaturase 3
, putative fatty acid desaturase
, cytochrome b5-related protein
, delta-9 fatty acid desaturase
, linoleoyl-CoA desaturase (delta-9-desaturase)-like 3