Fc Fragment of IgA, Receptor For Proteins (FCAR)

FCAR is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. Additionally we are shipping Fc Fragment of IgA, Receptor For Antibodies (191) and Fc Fragment of IgA, Receptor For Kits (26) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FCAR 2204 P24071
FCAR    
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Top Fc Fragment of IgA, Receptor For Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$6,041.49
Details
HOST_Human Cells Human His tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_Human Cells Rat His tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_Mammalian Cells Human His tag   50 μg Log in to see 4 Days
$280.50
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Human Human His tag   10 μg Log in to see 15 to 16 Days
$187.50
Details
HOST_Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 15 to 18 Days
$624.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Rat T7 tag,His tag   100 μg Log in to see 15 to 18 Days
$733.00
Details

FCAR Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , ,
, , , ,
Rat (Rattus) ,
,

More Proteins for Fc Fragment of IgA, Receptor For (FCAR) Interaction Partners

Cow (Bovine) Fc Fragment of IgA, Receptor For (FCAR) interaction partners

  1. have mapped the IgA binding site of bovine IgA Fc receptor and show that, in common with CD89, Tyr-35 in the B-C loop is essential for IgA binding

Pig (Porcine) Fc Fragment of IgA, Receptor For (FCAR) interaction partners

Human Fc Fragment of IgA, Receptor For (FCAR) interaction partners

  1. In transgenic mice, IgAN pathogenesis involves impaired clearance of abnormal IgA via CD89, primarily by the Kupffer cells. Conditional IgAN progression in CD89 transgenic mice thus reveals important aspects of IgAN pathogenesis.

  2. a novel Fcar splice variant termed variant APD isolated from a healthy volunteer that lacks only the IgA-binding EC1 domain, is reported.

  3. Findings suggest a basis for the use of Fc receptor I for IgA (FcalphaRI) as a molecular target for the treatment of lupus.

  4. this study examined the expression of IL-4 mRNA, IFN-c mRNA and FcaRI mRNA in tonsillar mononuclear cells of IgA nephropathy9(IgAN) patients and non-IgAN patients.

  5. FCAR polymorphism is not associated with high susceptibility to IGA nephropathy in caucasians.

  6. Abnormally glycosylated IgA1 and soluble CD89-IgA and IgA-IgG complexes, features of primary IgA nephropathy, are also present in alcoholic cirrhosis.

  7. Genetic variation at the promoter region of IgA receptor is associated with IgA nephropathy.

  8. These results suggest a role of anti-FcaRI Fab (show FANCB Proteins) as a negative regulator in controlling the magnitude of the innate immune response

  9. Glycosylation of the CH2 (show Acyp1 Proteins)/CH3 (show SOX3 Proteins) interface inhibits interaction with the pathogen IgA binding protein SSL7, while maintaining binding of pIgR (show PIGR Proteins), essential to the biosynthesis and transport of SIgA.

  10. There is an association between the levels of sCD89-IgA complexes in serum and the severity of IgA nephropathy, and a possible genetic component in regulating the production or expression of sCD89.

Fc Fragment of IgA, Receptor For (FCAR) Protein Profile

Protein Summary

This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with FCAR

  • Fc fragment of IgA, receptor for (FCAR)
  • CD89 protein

Protein level used designations for FCAR

IgA Fc receptor , immunoglobulin A Fc receptor , immunoglobulin alpha Fc receptor , Fc fragment of IgA, receptor for, isoform 7 , Fc alpha receptor

GENE ID SPECIES
503555 Bos taurus
664734 Macaca mulatta
100050205 Equus caballus
100137567 Papio anubis
100144539 Sus scrofa
2204 Homo sapiens
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