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FCGRT encodes a receptor that binds the Fc region of monomeric immunoglobulin G. Additionally we are shipping FCGRT Proteins (21) and FCGRT Kits (9) and many more products for this protein.
Showing 10 out of 78 products:
Human Polyclonal FCGRT Primary Antibody for IHC, IHC (fro) - ABIN4311282
Seijsing, Lindborg, Löfblom, Uhlén, Gräslund: Robust expression of the human neonatal Fc receptor in a truncated soluble form and as a full-length membrane-bound protein in fusion with eGFP. in PLoS ONE 2013
Show all 6 references for ABIN4311282
Cow (Bovine) Polyclonal FCGRT Primary Antibody for IHC, WB - ABIN2782616
Cianga, Cianga, Plamadeala, Branisteanu, Carasevici: The neonatal Fc receptor (FcRn) expression in the human skin. in Virchows Archiv : an international journal of pathology 2007
Human Polyclonal FCGRT Primary Antibody for IHC, IHC (p) - ABIN4311281
Deissler, Lang, Lang: Internalization of bevacizumab by retinal endothelial cells and its intracellular fate: Evidence for an involvement of the neonatal Fc receptor. in Experimental eye research 2015
Mouse (Murine) Polyclonal FCGRT Primary Antibody for FACS, WB - ABIN4899671
Baptista, Keszei, Oliveira, Sunahara, Andersson, Dahlberg, Worth, Liedén, Kuo, Wallin, Snapper, Eidsmo, Scheynius, Karlsson, Bouma, Burns, Forsell, Thrasher, Nylén, Westerberg: Deletion of Wiskott-Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells. in Nature communications 2016
The results suggest that regardless of hyperglycemia degree, it decreases FcRn expression in placenta and blood cells and compromises the production and transfer of antibodies from maternal blood to newborns.
Data indicate improved pharmacokinetics through enhanced neonatal Fc receptor (FcRn) interactions were apparent for a complementarity-determining region (CDR (show RUNX1T1 Antibodies)) charge-patch normalized monoclonal antibody (mAb) which was affected by non-specific clearance.
analysis of binding motifs in the hFCGRT promoter that interact with their corresponding (Sp1 (show PSG1 Antibodies), Sp2, Sp3 (show SP3 Antibodies), c-Fos, c-Jun (show JUN Antibodies), YY1 (show YY1 Antibodies), and C/EBPbeta (show CEBPB Antibodies) or C/EBPdelta (show CEBPD Antibodies)) transcription factors (TFs) suggests their involvement in regulation of human FCGRT gene expression
These data indicate that human FcRn facilitates the transepithelial transport of IgE in the form of IgG anti-IgE/IgE ICs.
none of the three functional polymorphisms in FcgammaR genes explored here, the FCGR3A (show CD16 Antibodies) F158V and FCGR2B (show FCGR2B Antibodies) I232T nsSNPs and the VNTR in FCGRT, showed an association with the response to TNFi in patients with rheumatoid arthritis
Critical Role of the Neonatal Fc Receptor (FcRn) in the Pathogenic Action of Antimitochondrial Autoantibodies Synergizing with Anti-desmoglein Autoantibodies in Pemphigus Vulgaris (show DSG3 Antibodies).
FcRn binding activity of a large set of Fc-fusion samples after thermal stress, was investigated.
The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity.
Molecular dynamic simulations of human FcRn-Fc binding structures proposed that the protein-protein binding interface is composed of three subsites.
This mAb panel provides a powerful resource for probing the biology of human FcRn and for the evaluation of therapeutic FcRn blockade strategies.
The transport of IgGs in the mammary gland, by FcRn, was investigated.
The present data support the notion that FcRn might be involved in the transfer of maternal immunoglobulins and in the local defense mechanism of the mammary gland.
FcRn alpha chain gene has acquired several repetitive sequences in its 5'-flanking region, including multiple SINE and LINE elements. Potential binding sites for transcription factors within the 5'-flanking sequence were identified
haplotype could also weaken the IgG-FcRn affinity, which may increase the IgG concentration in the milk.
Preproinsulin (show INS Antibodies) fused to Fc administered to pregnant mice efficiently accumulated in fetuses through the placental neonatal Fc receptor and protected them from subsequent diabetes development.
Characterization and screening of IgG binding to the neonatal Fc receptor.
Fc receptor promotes formation of subepithelial immune complexes and subsequent glomerular pathology leading to proteinuria
Abundant intracellular IgG in enterocytes and endoderm lacking FcRn.
Extending serum half-life of albumin (show ALB Antibodies) by engineering neonatal Fc receptor (FcRn) binding.
FcRn thus has a primary role within mucosal tissues in activating local immune responses that are critical for priming efficient anti-tumor immunosurveillance
Neonatal Fc receptor for IgG uptake mediates intestinal absorption of IgG(1) anti-IgE/IgE immune complexes.
Nck (show NCK1 Antibodies) and Cdc42 (show CDC42 Antibodies) co-operate to recruit N-WASP (show WASL Antibodies) to promote FcgammaR-mediated phagocytosis.
AMG (show AMELX Antibodies) 386 clearance in FcRn-knockout mice was 18-fold faster at the 3-mg/kg dose.
This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants.
FcRn alpha chain
, IgG Fc fragment receptor transporter alpha chain
, IgG receptor FcRn large subunit p51
, immunoglobulin receptor, intestinal, heavy chain
, major histocompatibility complex class I-like Fc receptor
, neonatal Fc receptor
, neonatal Fc-receptor for Ig
, IgG transcytosis and recycling receptor
, MHC class I-related Fc gamma receptor
, igG receptor FcRn large subunit p51
, neonatal Fc receptor FcRn
, Fc receptor
, Fc fragment immunoglobulin G receptor
, Fc receptor, IgG, alpha chain transporter
, igG Fc fragment receptor transporter alpha chain