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FCGR3A Proteins

(Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A))
This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
FCGR3A Protein (AA 17-208) (His-Avi Tag) FCGR3A Protein (AA 17-208) (His-Avi Tag) FCGR3A Protein (AA 17-208) (His-Avi Tag) (ABIN7274281)

FCGR3A Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

FCGR3A Protein (His-Avi Tag,Biotin) FCGR3A Protein (His-Avi Tag,Biotin) FCGR3A Protein (His-Avi Tag,Biotin) (ABIN7274282)

FCGR3A Origin: Human Host: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC

FCGR3A Protein (AA 17-254) (GST tag) FCGR3A Protein (AA 17-254) (GST tag) FCGR3A Protein (AA 17-254) (GST tag) (ABIN1353901)

FCGR3A Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA

FCGR3A Proteins by Grade

Find FCGR3A Proteins with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

FCGR3A Proteins by Origin

Find FCGR3A Proteins for a variety of species such as anti-Human FCGR3A, anti-Mouse FCGR3A, anti-Rat FCGR3A. The species listed below are among those available. Click on a link to go to the corresponding products.

FCGR3A Proteins by Source

Here you will find FCGR3A Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

FCGR3A Proteins by Protein Type

Here you can find FCGR3A Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

FCGR3A Proteins by Application

Find FCGR3A Proteins validated for a specific application such as WB, SDS, ELISA, Imm. Some of the available applications are listed below. Click on a link to go to the corresponding products.

FCGR3A Proteins by Biological Activity

Find FCGR3A Proteins with a specific Biological Activity. The Biological Activity listed below are among those available. Click on a link to go to the corresponding products.

Popular FCGR3A Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (4)
Cat. No. ABIN7274281
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (4)
Cat. No. ABIN7274282
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1353901
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (2)
  • (2)
Cat. No. ABIN2181078
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN6961127
Quantity 100 μg
Datasheet Datasheet
Reactivity Cynomolgus
Source Human Cells
Validations
  • (1)
Cat. No. ABIN7321023
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN7195704
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN7195697
Quantity 100 μg
Datasheet Datasheet
Reactivity Rat
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN7195703
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN7317018
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3080129
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3112214
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN2870739
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN2870544
Quantity 200 μg
Datasheet Datasheet
Reactivity Human
Source Human Cells
Validations
Cat. No. ABIN1096633
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our FCGR3A Proteins

de Taeye, Bentlage, Mebius, Meesters, Lissenberg-Thunnissen, Falck, Sénard, Salehi, Wuhrer, Schuurman, Labrijn, Rispens, Vidarsson: "FcγR Binding and ADCC Activity of Human IgG Allotypes." in: Frontiers in immunology, Vol. 11, pp. 740, (2020) (PubMed).

Aoyama, Hashii, Tsukimura, Osumi, Harazono, Tada, Kiyoshi, Matsuda, Ishii-Watabe: "Effects of terminal galactose residues in mannose α1-6 arm of Fc-glycan on the effector functions of therapeutic monoclonal antibodies." in: mAbs, Vol. 11, Issue 5, pp. 826-836, (2020) (PubMed).

Simonov, Ivanov, Smolov, Abbasova, Piskunov, Poteryaev: "Control of therapeutic IgG antibodies galactosylation during cultivation process and its impact on IgG1/FcγR interaction and ADCC activity." in: Biologicals : journal of the International Association of Biological Standardization, Vol. 58, pp. 16-21, (2019) (PubMed).

Zhao, Li, Wu, Li, Liu, Wang, Liu, Li, Wang: "Identification of anti-CD16a single domain antibodies and their application in bispecific antibodies." in: Cancer biology & therapy, pp. 1-9, (2019) (PubMed).

Huang, Li, Liu, Ye, Fan, Yuan, Wu, Chen, Jin, Shen, Feng, Zhang: "Structural and functional characterization of MBS301, an afucosylated bispecific anti-HER2 antibody." in: mAbs, Vol. 10, Issue 6, pp. 864-875, (2019) (PubMed).

Dakshinamurthy, Mukunda, Prasad Kodaganti, Shenoy, Natarajan, Maliwalave, Halan, Murugesan, Maity: "Charge variant analysis of proposed biosimilar to Trastuzumab." in: Biologicals : journal of the International Association of Biological Standardization, Vol. 46, pp. 46-56, (2017) (PubMed).

Hayes, Frostell, Cosgrave, Struwe, Potter, Davey, Karlsson, Anneren, Rudd: "Fc gamma receptor glycosylation modulates the binding of IgG glycoforms: a requirement for stable antibody interactions." in: Journal of proteome research, Vol. 13, Issue 12, pp. 5471-85, (2014) (PubMed).

Sakamoto, Ito, Hatanaka, Soni, Mori, Sugimura: "Discovery and characterization of a peptide motif that specifically recognizes a non-native conformation of human IgG induced by acidic pH conditions." in: The Journal of biological chemistry, Vol. 284, Issue 15, pp. 9986-93, (2009) (PubMed).

Aliases for FCGR3A Proteins

Fc fragment of IgG receptor IIIa (FCGR3A) Proteins
Fc fragment of IgG receptor IIIa (Fcgr3a) Proteins
CD16 Proteins
CD16A Proteins
FCG3 Proteins
FCGR3 Proteins
Fcgr4 Proteins
FCGRIII Proteins
FCR-10 Proteins
FCRIII Proteins
FCRIIIA Proteins
IGFR3 Proteins
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