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Fc Receptor, IgG, Low Affinity IIb Proteins (FCGR2B)

FCGR2B encodes one of three members of a family of low-affinity immunoglobulin gamma Fc receptors found on the surface of many immune response cells. Additionally we are shipping FCGR2B Antibodies (180) and FCGR2B Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FCGR2B 2213 P31994
FCGR2B 289211 Q63203
FCGR2B 14130 P08101
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Top FCGR2B Proteins at antibodies-online.com

Showing 8 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Human Cells Mouse His tag,AVI tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Baculovirus infected Insect Cells Mouse His tag,AVI tag,Biotin 50 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$862.40
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$897.60
Details
Yeast Guinea Pig His tag   1 mg Log in to see 56 to 66 Days
$2,429.17
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,432.83
Details

FCGR2B Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Rat (Rattus)

Mouse (Murine) , , ,
, , ,

More Proteins for Fc Receptor, IgG, Low Affinity IIb (FCGR2B) Interaction Partners

Human Fc Receptor, IgG, Low Affinity IIb (FCGR2B) interaction partners

  1. Fc-gamma receptor (show FCGR1A Proteins) polymorphisms differentially influence susceptibility to systemic lupus erythematosus and lupus nephritis.

  2. FCGR2C SNPs that associated with vaccine efficacy in RV144 also strongly associated with the expression of FCGR2A (show FCGR2A Proteins)/C and one of them also associated with the expression of Fc receptor-like A (FCRLA (show FCRLA Proteins)), another Fc-gamma receptor (show FCGR1A Proteins) (FcgammaR) gene

  3. LPS (show IRF6 Proteins) activation of TLR4 (show TLR4 Proteins) significantly increased MARCH3 (show MARCH3 Proteins) expression and that siRNA against MARCH3 (show MARCH3 Proteins) prevented the decrease in FcgammaRIIb following LPS (show IRF6 Proteins) treatment.

  4. a rare FCGR2B null-variant allele was found, in which a polymorphic stop codon of FCGR2C is introduced into one FCGR2B gene

  5. Data show that gains or losses in copy numbers of Fc gamma receptors FCGR3A (show CD16 Proteins) were less frequent than for FCGR3B (show CD16 Proteins) and FCGR2C.

  6. FcgammaRIIB requires Btk (show BTK Proteins) and p38 MAPK (show MAPK14 Proteins) to mediate antigen-independent inhibition in human B cells.

  7. The FCGR2B variant leads to reduced serum IL-6 (show IL6 Proteins), later disease onset and reduced need for biological treatment, but does not seem to aggravate RA. The TM region variant is associated with a lower activation state of the Tregs and naive and memory B cells.

  8. FcgIIb on GM-CSF (show CSF2 Proteins) macrophages has a role in controlling immune complex-mediated inhibition of inflammatory signals

  9. none of the three functional polymorphisms in FcgammaR genes explored here, the FCGR3A (show CD16 Proteins) F158V and FCGR2B I232T nsSNPs and the VNTR in FCGRT (show FCGRT Proteins), showed an association with the response to TNFi in patients with rheumatoid arthritis

  10. Data show that the recombinant Fc gamma receptors FcgammaRIa (show FCGR1A Proteins), FcgammaRIIa, FcgammaRIIb, FcgammaRIIIa(Phe158/Val158), and FcgammaRIIIb glycosylation is complex and varied between receptors.

Mouse (Murine) Fc Receptor, IgG, Low Affinity IIb (FCGR2B) interaction partners

  1. CD32 is a crucial regulator of FVIII (show F8 Proteins)-specific B cells and is required for the differentiation of memory B cells into antibody-secreting cells.

  2. Aggregated alpha-Synuclein (alpha-syn) inhibited microglial phagocytosis. The inhibitory effect of aggregated alpha-syn on microglial phagocytosis was due to the activation of SHP-1 and FcgammaRIIB on microglia.

  3. Fcgr2b(-/-) mice lose bone upon the onset of a hypergammaglobulinemia or the administration of IgG1 immune complexes.

  4. IgG (FcgammaR) IIb is involved in the suppressive effect of immune complex on TLR9 (show TLR9 Proteins)-mediated CD40 (show CD40 Proteins), CD80 (show CD80 Proteins) and IL-6 (show IL6 Proteins) expression.

  5. these studies demonstrate for the first time the ability of FcgammaRIIB to regulate vaccine-induced IgA production and downmodulate immunity and protection.

  6. This inhibitory receptor present on dendritic cells, neutrophils, and B cells has an important role in controlling anti-myeloperoxidase (show MPO Proteins) autoimmunity and limiting pathological effector responses and glomerular disease.

  7. Deletion of FcgammaRIIb/ApoE (show APOE Proteins) induces an anti-inflammatory Treg/macrophage polarization that is atheroprotective.

  8. Fcgamma-RII and Fcgamma-RIII might participate in the uptake and/or transport of IgG through the intestinal epithelia of adult mice.

  9. Aging Siglec-G (show SIGLEC10 Proteins)-deficient and Siglec-G (show SIGLEC10 Proteins) 3/FcgammaRIIb double-deficient mice develop an autoimmune phenotype with elevated autoantibody levels and mild glomerulonephritis.

  10. This study demonstrated that the activating FcgammaRs-mediated inflammation plays a critical role in anti-ganglioside Abs-induced neuropathy (injury to intact nerve fibers) in GBS (show GNB5 Proteins).

FCGR2B Protein Profile

Protein Summary

This gene encodes one of three members of a family of low-affinity immunoglobulin gamma Fc receptors found on the surface of many immune response cells. The encoded protein is a transmembrane glycoprotein and may be involved in phagocytosis and clearing of immune complexes. An allelic polymorphism in this gene results in both coding and non-coding variants.

Gene names and symbols associated with FCGR2B

  • Fc fragment of IgG, low affinity IIb, receptor (CD32) (FCGR2B)
  • Fc fragment of IgG, low affinity IIb, receptor (CD32) (FCGR2)
  • Fc fragment of IgG, low affinity IIb, receptor (CD32) (Fcgr2b)
  • Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene) (FCGR2C)
  • Fc receptor, IgG, low affinity IIb (Fcgr2b)
  • Fc-gamma-1/gamma-2 receptor (Gpifcgr)
  • AI528646 protein
  • CD32 protein
  • CD32B protein
  • CD32C protein
  • CDW32 protein
  • F630109E10Rik protein
  • FCG2 protein
  • Fcgr2 protein
  • Fcgr2a protein
  • FCGR2B protein
  • FcgRII protein
  • Fcr-2 protein
  • Fcr-3 protein
  • FcRII protein
  • FCRIIC protein
  • Fc[g]RII protein
  • IGFR2 protein
  • Ly-17 protein
  • Ly-m20 protein
  • Lym-1 protein

Protein level used designations for FCGR2B

CDw32 , Fc fragment of IgG, low affinity II, receptor for (CD32) , Fc fragment of IgG, low affinity IIb, receptor for (CD32) , Fc gamma RIIb , fc-gamma RII-b , fc-gamma-RIIb , fcRII-b , igG Fc receptor II-b , low affinity immunoglobulin gamma Fc region receptor II-b , fc-gamma RII , fcRII , igG Fc receptor II , low affinity immunoglobulin gamma Fc region receptor II , FC-gamma RII , Fc receptor, IgG, low affinity IIb , igG Fc receptor II beta , low affinity immunoglobulin gamma FC region receptor II , Fc gamma receptor IIC , IgG Fc receptor II-c , fc-gamma-RIIc , immunoglobulin G Fc receptor II-c , low affinity immunoglobulin gamma Fc region receptor II-c , Fc gamma RIIB , Fc-gamma-RII , FcgammaRIIB , fc gamma receptor IIB , fc-gamma-RIIB , lymphocyte antigen 17 , Fc-gamma RII , IgG Fc receptor II

GENE ID SPECIES
2213 Homo sapiens
282229 Bos taurus
289211 Rattus norvegicus
9103 Homo sapiens
14130 Mus musculus
100192391 Cavia porcellus
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