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FLVCR1 encodes a member of the major facilitator superfamily of transporter proteins. Additionally we are shipping Feline Leukemia Virus Subgroup C Cellular Receptor 1 Proteins (5) and many more products for this protein.
Showing 10 out of 46 products:
Human Polyclonal FLVCR1 Primary Antibody for ELISA, WB - ABIN185315
Quigley, Yang, Worthington, Phillips, Sabo, Sabath, Berg, Sassa, Wood, Abkowitz: Identification of a human heme exporter that is essential for erythropoiesis. in Cell 2004
Human Monoclonal FLVCR1 Primary Antibody for RNAi, ELISA - ABIN565398
Alves, Costa, Sorgine, Nascimento-Silva, Teodosio, Bárcena, Castro-Faria-Neto, Bozza, Orfao, Oliveira, Maya-Monteiro: Heme-oxygenases during erythropoiesis in K562 and human bone marrow cells. in PLoS ONE 2011
Chimpanzee Polyclonal FLVCR1 Primary Antibody for EIA, WB - ABIN374494
Rey, Duffy, Brown, Kennedy, Dick, Dror, Tailor: Enhanced alternative splicing of the FLVCR1 gene in Diamond Blackfan anemia disrupts FLVCR1 expression and function that are critical for erythropoiesis. in Haematologica 2008
Flvcr1 regulates differentiation of erythroid progenitors by controlling intracellular heme accumulation.
both HIF2alpha (show EPAS1 Antibodies) and ETS1 (show ETS1 Antibodies) are involved in the transcriptional regulation of Flvcr1a and that HIF2alpha (show EPAS1 Antibodies) is absolutely required for Flvcr1a induction upon hypoxia
FLVCR1 mutants failed to fold properly in the ER, were rapidly degraded in the lysosomes, and therefore, could not export heme out of cells. Thus, accumulation of heme in FLVCR1-mutant cells could cause cellular toxicity.
Study identified sequence variants in the known disease-causing genes SLC6A3 (show SLC6A3 Antibodies) and FLVCR1, and present evidence to strongly support the pathogenicity of variants identified in TUBGCP6 (show TUBGCP6 Antibodies), BRAT1 (show C7orf27 Antibodies), SNIP1 (show SNIP1 Antibodies), CRADD (show CRADD Antibodies), and HARS (show HARS Antibodies).
Posterior column ataxia (show USP14 Antibodies) with retinitis pigmentosa is caused by mutations in FLVCR1.
relative protein expression of 2 heme transporters, Feline Leukemia Virus, Subgroup C, Receptor 1 (FLVCR1) and Breast Cancer Resistance Protein (show ABCG2 Antibodies), was assessed in placental tissue in relation to maternal/neonatal iron status and placental iron concentration
These results suggest that aberrant FLVCR1 causes a selective degeneration of a subpopulation of neurons in the retina and the posterior columns of the spinal cord via dysregulation of heme or iron homeostasis.
hemopexin (show HPX Antibodies) directly interacts with FLVCR
the FLVCR gene on 1q31 is not involved in Diamond-Blackfan anemia in families studied
results suggest that multiple FLVCR1 regions are critical for mediating efficient feline leukemia virus subgroup C (FeLV-C) infection and that these regions are distinct from the FeLV-C envelope binding site
These studies identify a novel and unexpected role for FLVCR, a major facilitator superfamily metabolite transporter, in T cell development
Flvcr1a maintains a free heme pool that regulates heme synthesis and degradation as well as cytochromes P450 (show POR Antibodies) expression and activity.
FLVCR is redundant in stem cells but has critical and contrasting stage-specific roles in discrete hematopoietic lineages
Hemochromatosis (show HFE Antibodies) is associated not only with excessive accumulation of free iron in the retina and retinal pigment epithelium but also with excessive accumulation of heme.
data show that FLVCR exports heme & is required by erythroid progenitors to complete terminal differentiation; data show that FLVCR functions in macrophage heme-iron recycling and that systemic iron balance involves heme-iron trafficking via FLVCR
This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein is a heme transporter that may play a critical role in erythropoiesis by protecting developing erythroid cells from heme toxicity. This gene may play a role in posterior column ataxia with retinitis pigmentosa and the hematological disorder Diamond-Blackfan syndrome.
feline leukemia virus subgroup C cellular receptor 1
, feline leukemia virus subgroup C receptor-related protein 1
, feline leukemia virus subgroup C receptor-related protein 1-like
, feline leukemia virus subgroup C cellular receptor
, eline leukemia virus subgroup C cellular receptor 1