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Fermitin Family Member 2 Proteins (FERMT2)

Participates in the connection between ECM adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Additionally we are shipping FERMT2 Antibodies (57) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FERMT2 218952 Q8CIB5
FERMT2 10979 Q96AC1
Rat FERMT2 FERMT2 289992  
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Top FERMT2 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

FERMT2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for Fermitin Family Member 2 (FERMT2) Interaction Partners

Mouse (Murine) Fermitin Family Member 2 (FERMT2) interaction partners

  1. These findings show that talin and kindlin cooperatively activate integrins leading to fibronectin (show FN1 Proteins) binding and adhesion.

  2. These studies uncover a previously unrecognized function for Kindlin-2 and a mechanism for regulation of the chondrocyte differentiation programme and chondrogenesis.

  3. Taken together, our study suggests the suppressive roles of Kindlin-2 in the pathogenesis of colorectal carcinoma

  4. Data suggest that kindlin-2 (Kind2/Fermt2) interacts with actin alpha 2 (Actn2 (show ACTN2 Proteins)) and integrin beta 1 (Itgb1 (show ITGB1 Proteins)) and co-localizes to cardiac sarcomere at Z-disc; knockdown of Kind2 leads to dissociation of Actn2 (show ACTN2 Proteins) and Itgb1 (show ITGB1 Proteins).

  5. beta3/kindlin-2 interaction promotes outside-in alphaVbeta3 signaling selectively, with biological consequences in vivo [kindlin-2]

  6. kindlin-2 tyrosine phosphorylation and interaction with Src serve as a regulatable switch downstream of focal adhesion kinase in the integrin outside-in signaling circuit controlling cell migration and proliferation

  7. kindlin-2, through activating Ras and the downstream ERK1/2 and Akt (show AKT1 Proteins) signaling pathways, plays an important role in regulating renal tubular epithelial-to-mesenchymal transition

  8. C-terminal LIM (show PDLIM5 Proteins) domains of migfilin (show FBLIM1 Proteins) dictate its focal adhesion localization, and these domains mediate an interaction with kindlin in vitro and in cells, demonstrating that kindlin is important for normal migfilin (show FBLIM1 Proteins) dynamics.

  9. kindlin-2 regulates trafficking of endothelial cell surface enzymes that control platelet responses and hemostasis.

  10. Kindlin-2 mediates activation of TGF-beta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) signaling and renal fibrosis.

Human Fermitin Family Member 2 (FERMT2) interaction partners

  1. The F0 domain of K2 binds actin.

  2. data indicate that kindlin-2 promotes the invasiveness of prostate cancer cells largely through NF-kappaB (show NFKB1 Proteins)-dependent upregulation of MMP-9 (show MMP9 Proteins) and MMP-2 (show MMP2 Proteins)

  3. High kindlin-2 expression is associated with esophageal squamous cell carcinoma.

  4. our findings suggested that Kindlin-2 was highly expressed in hepatocellular carcinoma tissues and was closely related to clinical progression. Kindlin-2 protein could be a potential biomarker for predicting poor prognosis of HCC (show FAM126A Proteins) patients after surgery.

  5. findings suggest that Src (show SRC Proteins), Kindlin-2 and Migfilin (show FBLIM1 Proteins) together constitute a positive feedback loop that controls Src (show SRC Proteins) activity and regulates integrin-mediated cellular func

  6. Data indicate that Kindlin-2 mRNA levels in adult is highly expressed in mesoderm-derived organs.

  7. A major ILK (show ILK Proteins) binding site in the kindlin-2 FERM domain for regulating cell adhesion has been mapped.

  8. the first evidence that interaction between the integrin beta1 cytoplasmic tail and kindlin-2, a member of a family of adapters implicated in human disease pathogenesis, is mainly governed by the beta1 C-terminal carboxylate moiety

  9. Kindlin-2 was highly expressed in the peritumoral stroma of pancreatic ductal adenocarcinomas. Stromal kindlin-2 expression was related to nodal metastasis (P = 0.03).

  10. Kindlin-2 mediates activation of TGF-beta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) signaling and renal fibrosis.

FERMT2 Protein Profile

Protein Summary

Participates in the connection between ECM adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits migfilin (FBLP1) protein to cell-ECM focal adhesion sites (By similarity).

Gene names and symbols associated with FERMT2

  • fermitin family homolog 2 (Drosophila) (Fermt2)
  • fermitin family member 2 (FERMT2)
  • fermitin family member 2 (Fermt2)
  • AA960555 protein
  • KIND2 protein
  • Kindlin-2 protein
  • mig-2 protein
  • MIG2 protein
  • PLEKHC1 protein
  • UNC112 protein
  • UNC112B protein

Protein level used designations for FERMT2

fermitin family homolog 2 , mitogen inducible 2 , pleckstrin homology domain containing, family C (with FERM domain) member 1 , pleckstrin homology domain-containing family C member 1 , PH domain-containing family C member 1 , kindlin 2 , kindlin-2 , mitogen inducible gene 2 protein , mitogen-inducible gene 2 protein , pleckstrin homology domain containing, family C member 1

GENE ID SPECIES
218952 Mus musculus
10979 Homo sapiens
490693 Canis lupus familiaris
289992 Rattus norvegicus
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