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Fermitin Family Member 3 Proteins (FERMT3)

Kindlins are a small family of proteins that mediate protein-protein interactions involved in integrin activation and thereby have a role in cell adhesion, migration, differentiation, and proliferation. Additionally we are shipping FERMT3 Antibodies (53) and FERMT3 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse FERMT3 FERMT3 108101 Q8K1B8
FERMT3 83706 Q86UX7
Rat FERMT3 FERMT3 309186  
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Top FERMT3 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

FERMT3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,

More Proteins for Fermitin Family Member 3 (FERMT3) Interaction Partners

Xenopus laevis Fermitin Family Member 3 (FERMT3) interaction partners

Mouse (Murine) Fermitin Family Member 3 (FERMT3) interaction partners

  1. Mice expressing as little as 5% of kindlin-3 were viable and protected from spontaneous bleeding and infections. In vitro platelet functions, leukocyte adhesion, extravasation, and bacterial clearance were diminished. Bleeding time increased.

  2. The accumulation of HSPCs in the circulation of leukocyte adhesion deficiency type III patients, who lack Kindlin-3, underlines the conserved functions of Kindlin-3 in man and the importance of our findings for human disease.

  3. Optimal T cell activation and B cell antibody responses in vivo require the interaction between Integrin beta2 and kindlin-3.

  4. Direct binding of kindlin-3 to integrin alphaIIbbeta3 is involved in supporting integrin alphaIIbbeta3 activation and integrin alphaIIbbeta3-dependent responses of platelets and consequently contributes significantly to arterial thrombus formation.

  5. ADAP interacts with talin and kindlin-3 to promote platelet Integrin alphaIIbbeta3 activation and stable fibrinogen binding.

  6. the requirement of Kindlin-3 for effector T cells to induce alpha4beta1 and alphaLbeta2 integrin ligand binding and stabilization of integrin-ligand bonds is critical when integrin ligand levels are low, but of less importance when integrin ligand levels are high.

  7. This is the first in vivo demonstration that Kindlin-3-stabilized integrin adhesions, although essential for lymphocyte arrest on blood vessels and interstitial motility, are not obligatory for leukocyte diapedesis.

  8. the beta-2-integrin-kindlin-3 interaction is particularly important in adhesion strengthening under shear flow, and for T-cell homing to lymph nodes, but dispensable for T cell activation which occurs in a shear-free environment

  9. Kindlin-3 is central to conversion of mechanical force to intracellular signaling via calcium influx.

  10. Data indicate that Kindlin-3 specifically recognizes the integrin membrane-distal tail NPXY motif in both the beta(1A) and beta(1D) isoforms.

Human Fermitin Family Member 3 (FERMT3) interaction partners

  1. NMR studies demonstrated that the F1 loop of kindlin-3 is globally unfolded but stretches of residues assuming transient helical conformations could be detected in aqueous solution.

  2. Suppression of the Kindlin-2 (show FERMT2 Proteins)-integrin beta1-AKT (show AKT1 Proteins) regulatory axis is an alternative mechanism underlying the tumor suppressor function of miR (show MLXIP Proteins)-200b in esophageal squamous cell carcinoma.

  3. Kindlin-3/FERMT3 is upregulated in atherosclerotic, mainly in cells of monocytic origin and of M2 type. Simultaneous upregulation of ITGB2 (show ITGB2 Proteins) suggests a synergistic effect on leukocyte adherence and transmigration into the vessel wall.

  4. The accumulation of HSPCs in the circulation of leukocyte adhesion deficiency type III patients, who lack Kindlin-3, underlines the conserved functions of Kindlin-3 in man and the importance of our findings for human disease.

  5. A new C>T point mutation was found in exon 13 in the FERMT3 gene in an infant diagnosed with LAD (show DLD Proteins)-III. KINDLIN-3 expression is required for platelet aggregation and leukocyte function, but also osteoclast-mediated bone resorption.

  6. Mig-2 (show FERMT2 Proteins) significantly attenuates the antitumor action of cisplatin.

  7. The data uncover a novel and unexpected tumor suppressor role of Kindlin-3 which can influence integrins targeted therapies development.

  8. High Kindlin-2 (show FERMT2 Proteins) expression promotes pancreatic ductal adenocarcinoma progression.

  9. These data identify a role of kindlin-3 phosphorylation in integrin b3 activation and provide a basis for functional differences between kindlin-3 and the two other kindlin paralogs.

  10. Kindlin 2 (show FERMT2 Proteins) expression was significantly increased in luteinized granulosa cells from patients with polycystic ovary syndrome.

FERMT3 Protein Profile

Protein Summary

Kindlins are a small family of proteins that mediate protein-protein interactions involved in integrin activation and thereby have a role in cell adhesion, migration, differentiation, and proliferation. The protein encoded by this gene has a key role in the regulation of hemostasis and thrombosis. This protein may also help maintain the membrane skeleton of erythrocytes. Mutations in this gene cause the autosomal recessive leukocyte adhesion deficiency syndrome-III (LAD-III). Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with FERMT3

  • fermitin family member 3 (fermt3)
  • fermitin family member 3 (FERMT3)
  • fermitin family homolog 3 (Drosophila) (Fermt3)
  • fermitin family member 3 (Fermt3)
  • C79673 protein
  • KIND3 protein
  • Kindlin3 protein
  • MGC69069 protein
  • MGC88900 protein
  • MIG-2 protein
  • MIG2B protein
  • RGD1310168 protein
  • UNC112C protein
  • URP2 protein
  • URP2SF protein

Protein level used designations for FERMT3

fermitin family member 3 , fermitin family homolog 3 , unc-112-related protein 2 , MIG2-like protein , UNC-112 related protein 2 , kindlin 3 , kindlin-3

GENE ID SPECIES
379715 Xenopus laevis
448215 Xenopus (Silurana) tropicalis
100050011 Equus caballus
108101 Mus musculus
83706 Homo sapiens
483766 Canis lupus familiaris
309186 Rattus norvegicus
525159 Bos taurus
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