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The protein encoded by FBN2 is a component of connective tissue microfibrils and may be involved in elastic fiber assembly. Additionally we are shipping Fibrillin 2 Kits (23) and Fibrillin 2 Proteins (4) and many more products for this protein.
Showing 10 out of 73 products:
Human Polyclonal Fibrillin 2 Primary Antibody for IHC, IHC (fro) - ABIN4311657
Yabe, Hagiwara, Tsuchiya, Honda, Hatori, Sonofuchi, Kanazawa, Koide, Sekiguchi, Itaya, Itoi: Decreased elastic fibers and increased proteoglycans in the ligamentum flavum of patients with lumbar spinal canal stenosis. in Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2016
Show all 2 references for ABIN4311657
Human Polyclonal Fibrillin 2 Primary Antibody for ELISA, WB - ABIN185518
Quondamatteo, Reinhardt, Charbonneau, Pophal, Sakai, Herken: Fibrillin-1 and fibrillin-2 in human embryonic and early fetal development. in Matrix biology : journal of the International Society for Matrix Biology 2003
Mouse (Murine) Polyclonal Fibrillin 2 Primary Antibody for ELISA, WB - ABIN185738
Carta, Pereira, Arteaga-Solis, Lee-Arteaga, Lenart, Starcher, Merkel, Sukoyan, Kerkis, Hazeki, Keene, Sakai, Ramirez: Fibrillins 1 and 2 perform partially overlapping functions during aortic development. in The Journal of biological chemistry 2006
The coordinate upregulation of fibrillin-1 (show FBN1 Antibodies) and fibrillin-2 expression with the onset of tropoelastin (show ELN Antibodies) production is consistent with a role in elastic fiber assembly.
This is the first study to investigate the expression and localization of fibrillin proteins and latent TGF-beta (show TGFB1 Antibodies) binding proteins affecting TGFbeta (show TGFB1 Antibodies) bioavailability in the ovary.
The presence of the splice site mutation in FBN2 gene has been confirmed in a Japanese family with congenital contractural arachnodactyly complicated with aortic dilatation and dissection.
DNA sequence variation within the FBN2 gene is associated with both Achilles tendon (AT) and anterior cruciate ligament (ACL (show ACLY Antibodies)) rupture.
Rare and common variants in extracellular matrix gene Fibrillin 2 (FBN2) are associated with macular degeneration.
we demonstrate an important role for FBN1 (show FBN1 Antibodies) and FBN2 in AIS (show AR Antibodies) pathogenesis. We show that rare variants are enriched in severely affected AIS (show AR Antibodies) patients and are significantly associated with curve severity.
There was no association of overall methylation of FBN2 in the serum DNA with age, maximal tumor size, extent of tumor, tumor site, histology, presence of lymph node metastasis, distant metastasis, or Dukes' stage.
These results suggest that both fibrillin-1 (show FBN1 Antibodies) and fibrillin-2 are essential for the formation of thick oxytalan fibers in the ciliary zonule.
Data demonstrated that N-terminal fibrillin-2 epitopes are masked in postnatal microfibrils.
Data show that in wound healing and sclerotic skin diseases, a marked increase of fibrillin-2 expression was found by immunohistology.
Ten novel mutations have been identified in the critical region of FBN2, indicating a mutation detection rate of 75% in this limited region; none of the mutations altered amino acids in the calcium binding consensus sequence of EGF (show EGF Antibodies)-like domains.
fibrillins can directly interact in an N- to C-terminal fashion to form homotypic fibrillin-1 (show FBN1 Antibodies) or heterotypic fibrillin-1 (show FBN1 Antibodies)/fibrillin-2 microfibrils
Fibrillin-2 and periostin (show POSTN Antibodies) are target genes in Osterix (show SP7 Antibodies)-mediated osteoblast differentiation.
These results suggest that both fibrillin-1 (show FBN1 Antibodies) and fibrillin-2 expression is required to form thick oxytalan fibers in periodontal ligament.
Fibrillin-2 plays a role in forelimb muscle differentiation and infiltration of fat into the limb connective tissue space.
the bronchial epithelial dysplasia accompanying microfibril dysregulation in Adamtsl2 (show ADAMTSL2 Antibodies)(-/-) mice cannot be reversed by TGFbeta (show TGFB1 Antibodies) neutralization, and thus might be mediated by other mechanisms.
We propose that the Mp "worse-than-null" eye phenotype plausibly results from a failure in normal trafficking of proteins that are co-expressed with Fbn2 within the ciliary margin
Fbn2 has an indispensable role in ocular morphogenesis in mice. The high incidence of iris coloboma in Fbn2-null animals implies a previously unsuspected role in optic fissure closure.
fibrillin-2 exerts a greater positive influence on the mechanical properties of bone than fibrillin-1 (show FBN1 Antibodies) assemblies
Fibrillin-1 and -2, the structural components of extracellular microfibrils, differentially regulate TGF-beta and bone morphogenetic protein (BMP) bioavailability in bone.
Findings indicate that Fbn2 is involved in integrity of structures required for strength in limb movement.
interaction with microfibril-associated glycoprotein-2 (show MFAP5 Antibodies)
The protein encoded by this gene is a component of connective tissue microfibrils and may be involved in elastic fiber assembly. Mutations in this gene cause congenital contractural arachnodactyly.
, fibrillin 5
, fibrillin 2 (congenital contractural arachnodactyly)
, syndatyly ems