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FBN3 encodes a protein that belongs to the fibrillin gene family. Additionally we are shipping Fibrillin 3 Antibodies (3) and and many more products for this protein.
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an association study showed a potential association of the D19S884 marker with PCOS in Chinese Han women and the meta-analysis identified that the A8 allele may increase susceptibility to PCOS
The FBN3 risk allele may be associated with changes in basal glucose homeostasis in PCOS.
Data show that TGF-beta (show TGFB1 ELISA Kits) pathways operate during ovarian fetal development, and fibrillin 3 is highly expressed at a critical stage early in developing human and bovine fetal ovaries.
fibrillin-3, compared to the other fibrillins, fulfills both overlapping and distinct functions in human development
A variant in the fibrillin-3 gene is associated with TGF-beta and inhibin B levels in women with polycystic ovary syndrome.
Loss of fibrillin-3 during folliculogenesis may be an important factor in polycystic ovary syndrome pathogenesis.
Single nucleotide polymorphisms in FBN3 occur and may be a candidate gene for polycystic ovary syndrome.
Data show that fibrillin 3 appears to have little involvement in PCOS but cannot rule out that other markers in the region of chromosome 19p13.2 are associated with PCOS or that FBN3 expression occurs in other organs that may influence the PCOS phenotype.
fibrillin-3 gene showed the strongest evidence for association with Polycystic ovary syndrome
This is the first study to investigate the expression and localization of fibrillin proteins and latent TGF-beta (show TGFB1 ELISA Kits) binding proteins affecting TGFbeta (show TGFB1 ELISA Kits) bioavailability in the ovary.
This gene encodes a protein that belongs to the fibrillin gene family. Fibrillins are extracellular matrix molecules that assemble into microfibrils in many connective tissues. This gene is most highly expressed in fetal tissues and its protein product is localized to extracellular microfibrils of developing skeletal elements, skin, lung, kidney, and skeletal muscle. This gene is potentially involved in Weill-Marchesani syndrome. While several transcript variants may exist for this gene, their full-length natures have not been described to date.
, fibrillin 2 (congenital contractural arachnodactyly)