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The protein encoded by FGG is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Additionally we are shipping Fibrinogen gamma Chain Antibodies (160) and Fibrinogen gamma Chain Kits (24) and many more products for this protein.
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These results suggest that among the elderly, gamma ' fibrinogen does not add much to cardiovascular disease prediction beyond traditional risk factors and total fibrinogen level.
Fibrinogen was significantly increased in pediatric patients with complicated appendicitis compared to patients with uncomplicated appendicitis or non-specific abdominal pain.
Gene polymorphisms FGG C>T (rs6536024) were not associated with height, weight, or morbid obesity among European subjects.
A lower plasma concentration of gamma' gamma fibrinogen in healthy adults does not appear to increase venous thromboembolism risk.
Neutrophilic asthma patients and eosinophilic asthma patients had increased fibrinogen compared to controls.
congenital dysfibrinogenemia with a novel mutation in fibrinogen gamma chain (gamma322 Phe-->Ile, Fibrinogen Beijing) and haemophilia B in a family
5877G>A mutation in the exon 8 of the FGG gene is underlies the pathogenesis of congenital dysfibrinogenemia in a Chinese family.
Thrombin (show F2 Proteins) and fibrinogen gamma' regulate protofibril packing within fibrin fibers and thereby influence clot (show TXNDC17 Proteins) stiffness.
Case Reports: clustering of mutations causing fibrinogen storage disease in the fibrinogen gamma chain between residues 284 and 375.
Data indicate that mutations of the fibrinogen (Fg) gene seem to aggregate to the D region of fibrinogen gamma chain (FGG)
Data suggest the potential compensatory role of fibrinogen in restoring coagulation function in vivo after hemorrhagic shock.
Report role of gamma'-fibrinogen in control of hemostatic clot (show TXNDC17 Proteins) growth in the venous circulation.
Fibrinogen from mice harboring the Fibgamma390-396A mutation exhibited reduced binding to FXIII, and plasma from these mice exhibited delayed FXIII activation and fibrin crosslinking, indicating these residues mediate FXIII binding and activation.
elevated levels of gammaA/gammaA fibrinogen promote arterial thrombosis in vivo, whereas gammaA/gamma' does not
the gamma'/total fibrinogen ratio is associated with short-term outcome in ischaemic stroke
Platelet receptor engagement of the Fgg chain contributes to the stable incorporation of platelets into thrombi. Fibrinogen is internalized through alpha IIb beta 3 engagement of the Fgg chain; this interaction controls fibronectin (show FN1 Proteins) content of platelets.
smaller thrombi result from the ability of fibrin to bind and sequester thrombin and/or the ability of the altered fibrinogen molecules, which cannot recruit platelets, to bind to and passivate the surface.
The Studies have shown that gamma chain binding to thrombin (show F2 Proteins) and factor XIII (show UGDH Proteins) results in clots that are mechanically stiffer and resistant to fibrinolysis, which may explain the association between gammaA/gamma' fibrinogen levels and cardiovascular disease.
the engagement of alphaIIb beta3 by the C-terminal sequence of the fibrinogen gamma-chain initiates signals that suppress subsequent fibronectin (show FN1 Proteins) assembly by spread platelets
The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms.
fibrinogen, gamma chain
, fibrinogen gamma chain
, fibrinogen gamma chain-like
, fibrinogen, gamma polypeptide
, fibrinogen gamma polypeptide
, fibrinogen gamma-B chain
, fibrinogen gamma-chain
, gamma chain
, gamma polypeptide