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Fibrinogen-like 1 is a member of the fibrinogen family. Additionally we are shipping FGL1 Antibodies (101) and FGL1 Kits (36) and many more products for this protein.
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Hepassocin plays an important role in non-alcoholic fatty liver disease and induces hepatic lipid accumulation through an ERK1/2-dependent pathway.
Here, the application of small ubiquitin-related modifier (SUMO) fusion technology in combination with four different chaperone teams on the soluble expression of recombinant HPS protein was explored and analyzed.
Findings suggest that hepassocin promotes hepatic cell line L02 cells proliferation via an autocrine mechanism and inhibits HCC (show FAM126A Proteins) cells proliferation by an intracrine pathway.
data demonstrated that liver-specific gene LFIRE-1/HFREP-1 was frequently downregulated and might possess growth suppressor activity in HCC (show FAM126A Proteins)
HFREP-1 in plasma almost completely bound to the fibrin matrix during clot (show TXNDC17 Proteins) formation
The enhancement of FGL1 levels in vitro by IL-6 (show IL6 Proteins) and its induction after turpentine oil injection suggest that it is an acute phase reactant.
HNF1 (show HNF1A Proteins) binding site and HNF1alpha (show HNF1A Proteins) are critical to liver-specific expression of HPS (show HPS1 Proteins), and down-regulation or loss of HNF1alpha (show HNF1A Proteins) causes, at least in part, the transcriptional down-regulation of HPS (show HPS1 Proteins) in HCC (show FAM126A Proteins).
The results suggest that Fgl1 acts as a tumor suppressor in hepatocellular cancer through an Akt (show AKT1 Proteins)-dependent mechanism and support its role as a potential therapeutic target in hepatocellular carcinoma.
Fgl1 is a member of an emerging group of proteins with key roles in metabolism and liver regeneration.
HNF1 (show HNF1A Proteins) binding site and HNF1alpha (show HNF1A Proteins) are critical to liver-specific expression of HPS, and down-regulation or loss of HNF1alpha (show HNF1A Proteins) causes, at least in part, the transcriptional down-regulation of HPS in HCC (show FAM126A Proteins).
Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene.
, fibrinogen-like protein 1
, fibrinogen-related protein 1
, fibronigen-like protein 1
, liver fibrinogen-related protein 1
, hepatocellular carcinoma-related sequence
, hepatocyte-derived fibrinogen-related protein 1