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The protein encoded by FAP is a homodimeric integral membrane gelatinase belonging to the serine protease family. Additionally we are shipping Fibroblast Activation Protein, alpha Kits (27) and Fibroblast Activation Protein, alpha Proteins (18) and many more products for this protein.
Showing 10 out of 141 products:
Human Polyclonal FAP Primary Antibody for EIA, WB - ABIN401429
Ramirez-Montagut, Blachere, Sviderskaya, Bennett, Rettig, Garin-Chesa, Houghton: FAPalpha, a surface peptidase expressed during wound healing, is a tumor suppressor. in Oncogene 2004
Show all 8 references for ABIN401429
Human Monoclonal FAP Primary Antibody for WB - ABIN394545
Rose, Behm, Drgon, Johnson, Uhl: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. in Molecular medicine (Cambridge, Mass.) 2010
Show all 5 references for ABIN394545
Human Monoclonal FAP Primary Antibody for IP, ELISA - ABIN560844
Wang, Yao, Nadvi, Osborne, McCaughan, Gorrell: Fibroblast activation protein and chronic liver disease. in Frontiers in bioscience : a journal and virtual library 2007
Show all 4 references for ABIN560844
Human Polyclonal FAP Primary Antibody for WB - ABIN656472
Chen, Yang, Wen, Xu, Chen: TGF-beta induces fibroblast activation protein expression; fibroblast activation protein expression increases the proliferation, adhesion, and migration of HO-8910PM [corrected]. in Experimental and molecular pathology 2009
Human Polyclonal FAP Primary Antibody for IHC (p) - ABIN252929
Herrera, Herrera, Alba-Castellón, Silva, García, Loubat-Casanovas, Alvarez-Cienfuegos, Miguel García, Rodriguez, Gil, Ma Jesús Citores, Ma Jesús Larriba, Ignacio Casal, de Herreros, Bonilla, Peña: Protumorigenic effects of Snail-expression fibroblasts on colon cancer cells. in International journal of cancer 2014
Human Polyclonal FAP Primary Antibody for IF (p), IHC (p) - ABIN714311
Zhang, Jiang, Ling, Cao, Zhao, Tuo, She, Shen, Jiang, Hu, Pang: Enhanced Antitumor Activity of EGFP-EGF1-Conjugated Nanoparticles by a Multitargeting Strategy. in ACS applied materials & interfaces 2016
Soluble form of a seprase activity is detected in bovine serum
We clearly show an association between FAPalpha and chondrocytes in the context of cartilage degradation. (Fibroblast activation protein alpha)
FAP-vaccinated mice also treated with Cyclophosphamide chemotherapy showed a marked suppression of tumor growth (inhibition ratio =80%) and a prolongation of survival time.
In two different models of pulmonary fibrosis, intratracheal bleomycin instillation and thoracic irradiation, the study finds increased mortality and increased lung fibrosis in FAP-deficient mice compared with wild-type mice.
Mouse FGF-21 (show FGF21 Antibodies), however, lacks the FAP cleavage site and is not cleaved by FAP.
Data indicate that indolamine-2,3-dioxygenase (IDO (show IDO1 Antibodies)) and Fibroblast activation protein alpha (FAPalpha) were detectable in B16 melanoma tumor-bearing mice.
A transgenic mouse model for pulmonary fibrosis was generated. After bleomycin induction, luciferase cDNA under the control of the FAPa promoter presents strong luminescence in the lungs especially; the expression level reflects the degree of the disease.
Results indicate a bacterial adaptation that hijacks inflammasome activation via interactions between IpaH7.8 E3 ubiquitin ligase (show MUL1 Antibodies) and glomulin (GLMN (show GLMN Antibodies)).
The FAP(+) stromal cell may have roles in two adverse consequences of cancer.
In NIH 3T3 cells overexpressing recombinant mouse FAP, FAP enzymatic activity during matrix production is important for the topographical organization of the ECM (show MMRN1 Antibodies) fibers.
Authors conclude that the proteolytic activity of FAP participates in matrix degradation, but other functions of the protein stimulate increased tumor growth.
FAP may be a potentially useful marker for wound age determination.
DPP4 (show DPP4 Antibodies) activity and/or structure homologue (DASH) proteins are involved in many pathophysiological processes and have therefore been proposed for potential biomarkers or even drug targets in various cancers (DPP4 (show DPP4 Antibodies) and FAP). (Review)
FAP expression is significantly upregulated in human masticatory mucosa during wound healing
The level of FAP expression in NGP-127, SJCRH30, and SJSA-1 lines as well as in cancer-associated fibroblasts of patients was comparable, which makes these cell lines a possible model for studying FAP
NPY is efficiently cleaved by FAP indicating a potential function for FAP in neuropeptide regulation within liver and cancer biology.
degradomic study highlights cell-contextual proteolysis by FAPalpha with distinct positional profiles. Generally, our findings link FAPalpha to key aspects of CAF (show KAT2B Antibodies) biology and attribute an important role in tumor-stroma interaction to FAPalpha
Data suggest that a DNA vaccine targeting human fibroblast activation protein alpha (FAPalpha) may be an attractive and effective cancer immunotherapy strategy.
In this study, we show for the first time the expression of FAP in activated fibroblasts after MI and its activation by TGFbeta1 (show TGFB1 Antibodies). Effects of FAP on fibroblast migration and gelatinolytic activity indicate a potential role in cardiac wound healing
FAP is expressed by activated, collagen-synthesizing fibroblasts, but not by inactive fibroblasts or fully differentiated myofibroblasts and non-fibroblast cells in the infarct.
This study identified fibroblast activation protein (FAP) as the enzyme that cleaves and inactivates human FGF21 (show FGF21 Antibodies).
Human FGF-21 (show FGF21 Antibodies) Is a Substrate of Fibroblast Activation Protein.
The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis.
fibroblast activation protein, alpha
, fibroblast activation protein, alpha subunit
, gene 13
, fibroblast activation protein alpha
, integral membrane serine protease
, 170 kDa melanoma membrane-bound gelatinase
, FK506-binding protein-associated protein
, FKBP-associated protein