Fibroblast Growth Factor 14 Proteins (FGF14)

The protein encoded by FGF14 is a member of the fibroblast growth factor (FGF) family. Additionally we are shipping FGF14 Antibodies (47) and FGF14 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FGF14 2259 Q92915
FGF14 14169 P70379
FGF14 63851 Q8R5L7
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Top FGF14 Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 2 to 3 Days
$375.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 50 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Dog Un-conjugated 50 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,632.67
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 25 to 30 Days
$196.35
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 2 to 3 Days
$498.21
Details

FGF14 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Fibroblast Growth Factor 14 (FGF14) Interaction Partners

Human Fibroblast Growth Factor 14 (FGF14) interaction partners

  1. Either the FGF14(V160A) or the FGF14(K74A/I76A) mutation was sufficient to abolish the FGF14-dependent regulation of peak transient Na(+) currents and the voltage-dependent activation and steady-state inactivation of Nav1.6 (show SCN8A Proteins); but only V160A with a concomitant alanine mutation at Tyr (show TYR Proteins)-158 could impede FGF14-dependent modulation of the channel fast inactivation.

  2. study reports on a two-generation French Canadian family affected with autosomal dominant episodic ataxia caused by a frameshift mutation leading to a premature stop codon in FGF14

  3. identified the PI3K/Akt pathway, the cell-cycle regulator Wee1 kinase, and protein kinase C (PKC) as prospective regulatory nodes of neuronal excitability through modulation of the FGF14:Nav1.6 complex.

  4. family demonstrates phenotypic variability of FGF14 deletions (SCA 27), fever sensitivity of ataxia and the added value of SNP-array analysis in making a diagnosis

  5. inhibition of GSK3 reduces the assembly of the FGF14.Nav channel complex, modifies FGF14-dependent regulation of Na(+) currents, and induces dissociation and subcellular redistribution of the native FGF14.Nav channel complex in hippocampal neurons.

  6. THe present study demonstrates that Spinocerebellar ataxia type 27 (SCA27) caused by FGF14 mutation is rare in Chinese SCA patients.

  7. A mutation in the fibroblast growth factor 14 gene is associated with autosomal dominant cerebral ataxia

  8. A G->A variant was found in a single spinocerebellar ataxia patient in the 3' untranslated region, 31 bp to the STOP codon; it did not affect the polyadenylation site. FGF14 mutations are not a major cause of SCA in Caucasians.

  9. Frameshift mutation and polymorphisms in the fibroblast growth factor 14 gene is associated with ataxias

  10. these findings implicate FGF14 as a unique modulator of Nav channel activity in the CNS.

Mouse (Murine) Fibroblast Growth Factor 14 (FGF14) interaction partners

  1. TWEAK (show TNFSF12 Proteins)/Fn14 (show TNFRSF12A Proteins) pathway instrumental in the pathogenesis of spontaneous lupus nephritis

  2. FGF14 is localized in a decreasing proximal to distal gradient along the axon initial segment of Purkinje neurons.

  3. FGF14 regulates presynaptic Ca2 (show CA2 Proteins)+ channels and synaptic transmission in cultured rat neurons.

  4. inhibition of GSK3 reduces the assembly of the FGF14.Nav channel complex, modifies FGF14-dependent regulation of Na(+) currents, and induces dissociation and subcellular redistribution of the native FGF14.Nav channel complex in hippocampal neurons.

  5. Fgf14-deficient mice developed ataxia and a paroxysmal hyperkinetic movement disorder. FGF14 may mediate neuronal signaling, axonal trafficking and synaptosomal function.

  6. FGF14 in regulating synaptic plasticity via presynaptic mechanisms by affecting the mobilization, trafficking, or docking of synaptic vesicles to presynaptic active zones.

  7. these results suggest a role for FGF14 in certain spatial learning functions and synaptic plasticity

  8. Sodium channels in Fhf1 (show FGF12 Proteins)-/-Fhf4-/- granule neurons inactivate at more negative membrane potential, inactivate more rapidly, and are slower to recover from the inactivated state.

  9. results suggest that FGF14 is required for normal Nav1.6 (show SCN8A Proteins) expression in Purkinje neurons, and that the loss of FGF14 impairs spontaneous and repetitive firing in Purkinje neurons by altering the expression of Nav1.6 (show SCN8A Proteins) channels

FGF14 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with FGF14

  • fibroblast growth factor 14 (FGF14)
  • fibroblast growth factor 14 (fgf14)
  • fibroblast growth factor 14 (LOC100229510)
  • fibroblast growth factor 14 (LOC100358876)
  • fibroblast growth factor 14 (Fgf14)
  • FGF-14 protein
  • FGF14 protein
  • FHF-4 protein
  • Fhf4 protein
  • mFHF-4(1B) protein
  • SCA27 protein

Protein level used designations for FGF14

fibroblast growth factor homologous factor 4 , fibroblast growth factor 14 , bA397O8.2 , FGF-14 , FGF homologus factor 4b

GENE ID SPECIES
395554 Gallus gallus
497642 Danio rerio
701077 Macaca mulatta
739338 Pan troglodytes
100217328 Xenopus (Silurana) tropicalis
100229510 Taeniopygia guttata
100358876 Oryctolagus cuniculus
2259 Homo sapiens
14169 Mus musculus
63851 Rattus norvegicus
485537 Canis lupus familiaris
615488 Bos taurus
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