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Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression.. Additionally we are shipping FGF15 Kits (9) and FGF15 Antibodies (9) and many more products for this protein.
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This study reveals SHP (show LAMC1 Proteins) as a global transcriptional partner of SREBP-2 (show SREBF2 Proteins) in regulation of sterol biosynthetic gene networks and provides a potential mechanism for cholesterol-lowering action of FGF19 (show FGF19 Proteins).
Protective effects of farnesoid X receptor (show xpr1 Proteins) on hepatic lipid accumulation are mediated by hepatic FXR (show NR1H4 Proteins) and are independent of intestinal FGF15 signaling.
Intestinal PPARalpha (show PPARA Proteins)-UDP- Glucuronyltransferases and downstream FXR (show NR1H4 Proteins)-FGF15 signalling play vital roles in control of bile acid homeostasis and the pathological development of colitis.
a direct role of intestinal FGF15/19 in the regulation of SI P450 (show POR Proteins) expression and may have profound implications for the prediction of drug exposure in patients with compromised hepatic P450 (show POR Proteins) function
findings implicate the brain in the antidiabetic action of systemic FGF19 (show FGF19 Proteins) and establish the brain's capacity to rapidly, potently, and selectively increase insulin (show INS Proteins)-independent glucose disposal
Ileal Fibroblast Growth Factor-15 (FGF15) expression was significantly reduced in Asbt (show SLC10A2 Proteins)(-/-)apoE (show APOE Proteins)(-/-) mice and was inversely correlated with expression of hepatic cholesterol 7-hydroxylase (Cyp7a1 (show CYP7A1 Proteins)).
HNF4alpha (show HNF4A Proteins) and LRH-1 (show NR5A2 Proteins) promote active transcription histone marks on the Cyp7a1 (show CYP7A1 Proteins) promoter that are reversed by FGF19 (show FGF19 Proteins) in a SHP (show LAMC1 Proteins)-dependent manner
Total ileal FGF15 expression was elevated almost 20-fold in Ostalpha (show OSTALPHA Proteins)(-/-) mice as a result of increased villus epithelial cell number and ileocyte FGF15 protein expression
generated a variant of FGF19 (show FGF19 Proteins), FGF19 (show FGF19 Proteins)-7, that has altered receptor specificity with a strong bias toward FGFR1c
Differential specificity of endocrine FGF19 (show FGF19 Proteins) and FGF21 (show FGF21 Proteins) to FGFR1 (show FGFR1 Proteins) and FGFR4 (show FGFR4 Proteins) in complex with KLB (show KLB Proteins).
Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression.
, fibroblast growth factor 15