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Fibronectin Type III Domain Containing 5 Proteins (FNDC5)

mouse homolog is linked to myoblast differentiation and development [RGD, Feb 2006].. Additionally we are shipping FNDC5 Kits (75) and FNDC5 Antibodies (42) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FNDC5 252995 Q8NAU1
FNDC5 384061 Q8K4Z2
FNDC5 260327 Q8K3V5
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Top FNDC5 Proteins at antibodies-online.com

Showing 10 out of 28 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Human Human Fc Tag   10 μg Log in to see 5 to 8 Days
$183.75
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$771.10
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 5 to 8 Days
$194.25
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated SDS-PAGE (4-20%) of Recombinant Human Irisin: Recombinant Irisin Protein Ioaded under reducing conditions and stained with Coomassie Blue. The protein has a predicted MW of around 13.00 kDa. 50 μg Log in to see 2 to 3 Days
$861.00
Details
HOST_Human Human Fc Tag   10 μg Log in to see 5 to 8 Days
$309.75
Details

FNDC5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , , ,
Mouse (Murine) , , ,
, , ,
Rat (Rattus) , ,
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Top referenced FNDC5 Proteins

  1. Human FNDC5 Protein expressed in Wheat germ - ABIN1354283 : Boström, Wu, Jedrychowski, Korde, Ye, Lo, Rasbach, Boström, Choi, Long, Kajimura, Zingaretti, Vind, Tu, Cinti, Højlund, Gygi, Spiegelman: A PGC1-?-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. in Nature 2012 (PubMed)
    Show all 3 references for ABIN1354283

More Proteins for Fibronectin Type III Domain Containing 5 (FNDC5) Interaction Partners

Cow (Bovine) Fibronectin Type III Domain Containing 5 (FNDC5) interaction partners

  1. Neither FNDC5 nor its putatively secreted peptide irisin were found in circulation of bulls.

Human Fibronectin Type III Domain Containing 5 (FNDC5) interaction partners

  1. Crossfit training changes brain-derived neurotrophic factor (show BDNF Proteins) and irisin levels at rest, after wingate and progressive tests, and improves aerobic capacity and body composition of young physically active men and women

  2. Data suggest that secretion of irisin by skeletal muscle is up-regulated by exercise; irisin appears to be involved in regulation of energy metabolism, insulin (show INS Proteins) resistance, and cell differentiation. [REVIEW]

  3. Circulating irisin levels progressively decreased with the worsening of the glucose tolerance. Irisin correlated well with traditional biochemical and anthropometric parameters of metabolic health.

  4. The compositions of skeletal muscle and visceral fat play key roles in the association between circulating irisin and a patient's metabolic phenotype.

  5. Lower irisin level is associated with patients with type 2 diabetes mellitus.

  6. In patients with diabetes mellitus type 2, irisin correlated positively with insulin (show INS Proteins) sensitivity but is not associated with beta-cell function-related variables.

  7. Irisin concentrations are associated with the presence of diabetic nephropathy and diabetic retinopathy

  8. Irisin is a myokine decreasing gradually with the progression of glucose intolerance and type 2 diabetes mellitus, and it is not correlated with body mass index in sedentary women.

  9. Plasma irisin was higher in subjects with high adipose body content (>40%) than in lean subjects. Plasma irisin was associated with metabolic syndrome.

  10. irisin alleviates endothelial dysfunction in type 2 diabetes partially via reducing oxidative stresses through inhibiting signaling pathways suggesting that irisin may be a promising molecule for the treatment of vascular complications of diabetes.

Mouse (Murine) Fibronectin Type III Domain Containing 5 (FNDC5) interaction partners

  1. irisin does not function through inflammatory NFKB activation like other myokines (such as TNFalpha (show TNF Proteins)).

  2. Muscle FNDC5 mRNA expression and irisin release are not IL-15 (show IL15 Proteins)-dependent in mice.

  3. irisin alleviates endothelial dysfunction in type 2 diabetes partially via reducing oxidative stresses through inhibiting signaling pathways suggesting that irisin may be a promising molecule for the treatment of vascular complications of diabetes.

  4. HFD induced obese mice showed decreased irisin secretion from adipose tissues, which might contribute to muscle insulin (show INS Proteins) resistance.

  5. Our study also suggests the existence of irisin-specific receptor on the membrane of H9C2 cells. In conclusion, irisin in a certain concentration rage (show AGER Proteins) increased myocardial cell metabolism, inhibited cell proliferation and promoted cell differentiation

  6. In summary, these results suggested that the endothelium-dependent relaxation of irisin is mediated by the nitric oxide (NO)-guanosine 3', 5'-cyclic phosphate (cGMP)-dependent pathway.

  7. Fndc5 facilitates neural differentiation. This effect might be related to increased expression of BDNF (show BDNF Proteins) following overexpression of Fndc5.

  8. This study used irisin radiolabeled with (125)I and small-animal SPECT/CT imaging to investigate the metabolic elimination and distribution of irisin in vivo.

  9. High intensity exercise results in increased expression of Fndc5 in skeletal muscle.

  10. Increase PGC-1alpha expression during cardiac precursor cells formation stage via rosiglitazone treatment increase FNDC5 and mitochondrial markers transcript levels which enhanced cardiac differentiation efficiency.

FNDC5 Protein Profile

Protein Summary

mouse homolog is linked to myoblast differentiation and development

Gene names and symbols associated with FNDC5

  • fibronectin type III domain containing 5 (FNDC5)
  • fibronectin type III domain containing 5 (Fndc5)
  • fibronectin type III domain containing 5b (fndc5b)
  • 1500001L03Rik protein
  • AI836596 protein
  • C87088 protein
  • fndc5 protein
  • FRCP2 protein
  • irisin protein
  • PeP protein
  • Pxp protein
  • si:dkey-264p5.1 protein
  • zgc:158684 protein

Protein level used designations for FNDC5

fibronectin type III domain-containing protein 5 , fibronectin type III domain containing 5 , fibronectin type III repeat-containing protein 2 , peroxisomal protein

GENE ID SPECIES
419667 Gallus gallus
487302 Canis lupus familiaris
538905 Bos taurus
746970 Pan troglodytes
252995 Homo sapiens
384061 Mus musculus
260327 Rattus norvegicus
100726842 Cavia porcellus
101104971 Ovis aries
555635 Danio rerio
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