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mouse homolog is linked to myoblast differentiation and development [RGD, Feb 2006].. Additionally we are shipping FNDC5 Kits (74) and FNDC5 Antibodies (43) and many more products for this protein.
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Human FNDC5 Protein expressed in Wheat germ - ABIN1354283
Boström, Wu, Jedrychowski, Korde, Ye, Lo, Rasbach, Boström, Choi, Long, Kajimura, Zingaretti, Vind, Tu, Cinti, Højlund, Gygi, Spiegelman: A PGC1-?-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. in Nature 2012
Show all 3 references for ABIN1354283
Neither FNDC5 nor its putatively secreted peptide irisin were found in circulation of bulls.
Crossfit training changes brain-derived neurotrophic factor (show BDNF Proteins) and irisin levels at rest, after wingate and progressive tests, and improves aerobic capacity and body composition of young physically active men and women
Data suggest that secretion of irisin by skeletal muscle is up-regulated by exercise; irisin appears to be involved in regulation of energy metabolism, insulin (show INS Proteins) resistance, and cell differentiation. [REVIEW]
Circulating irisin levels progressively decreased with the worsening of the glucose tolerance. Irisin correlated well with traditional biochemical and anthropometric parameters of metabolic health.
The compositions of skeletal muscle and visceral fat play key roles in the association between circulating irisin and a patient's metabolic phenotype.
Lower irisin level is associated with patients with type 2 diabetes mellitus.
In patients with diabetes mellitus type 2, irisin correlated positively with insulin (show INS Proteins) sensitivity but is not associated with beta-cell function-related variables.
Irisin concentrations are associated with the presence of diabetic nephropathy and diabetic retinopathy
Irisin is a myokine decreasing gradually with the progression of glucose intolerance and type 2 diabetes mellitus, and it is not correlated with body mass index in sedentary women.
Plasma irisin was higher in subjects with high adipose body content (>40%) than in lean subjects. Plasma irisin was associated with metabolic syndrome.
irisin alleviates endothelial dysfunction in type 2 diabetes partially via reducing oxidative stresses through inhibiting signaling pathways suggesting that irisin may be a promising molecule for the treatment of vascular complications of diabetes.
irisin does not function through inflammatory NFKB activation like other myokines (such as TNFalpha (show TNF Proteins)).
Muscle FNDC5 mRNA expression and irisin release are not IL-15 (show IL15 Proteins)-dependent in mice.
HFD induced obese mice showed decreased irisin secretion from adipose tissues, which might contribute to muscle insulin (show INS Proteins) resistance.
Our study also suggests the existence of irisin-specific receptor on the membrane of H9C2 cells. In conclusion, irisin in a certain concentration rage (show AGER Proteins) increased myocardial cell metabolism, inhibited cell proliferation and promoted cell differentiation
In summary, these results suggested that the endothelium-dependent relaxation of irisin is mediated by the nitric oxide (NO)-guanosine 3', 5'-cyclic phosphate (cGMP)-dependent pathway.
Fndc5 facilitates neural differentiation. This effect might be related to increased expression of BDNF (show BDNF Proteins) following overexpression of Fndc5.
This study used irisin radiolabeled with (125)I and small-animal SPECT/CT imaging to investigate the metabolic elimination and distribution of irisin in vivo.
High intensity exercise results in increased expression of Fndc5 in skeletal muscle.
Increase PGC-1alpha expression during cardiac precursor cells formation stage via rosiglitazone treatment increase FNDC5 and mitochondrial markers transcript levels which enhanced cardiac differentiation efficiency.
mouse homolog is linked to myoblast differentiation and development
fibronectin type III domain-containing protein 5
, fibronectin type III domain containing 5
, fibronectin type III repeat-containing protein 2
, peroxisomal protein