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anti-Fibulin 4 (FBLN4) Antibodies

A large number of extracellular matrix proteins have been found to contain variations of the epidermal growth factor (EGF) domain and have been implicated in functions as diverse as blood coagulation, activation of complement and determination of cell fat. Additionally we are shipping Fibulin 4 Proteins (15) and Fibulin 4 Kits (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
FBLN4 293677  
FBLN4 30008 O95967
FBLN4 58859 Q9WVJ9
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Top anti-Fibulin 4 Antibodies at antibodies-online.com

Showing 10 out of 94 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated FACS, WB Western blot analysis of EFEMP2 Antibody (C-term) (ABIN653217) in HepG2 cell line lysates (35 µg/lane). EFEMP2 (arrow) was detected using the purified polyclonal antibody. Western blot analysis of EFEMP2 Antibody (C-term) (ABIN653217) in mouse NIH-3T3 cell line lysates (35 µg/lane). EFEMP2 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, FACS, WB Flow cytometric analysis of HepG2 cells (bottom histogram) compared to a negative control cell (top histogram) using Fibulin-4  Antibody  (C-term), followed by FITC-conjugated goat-anti-rabbit secondary antibodies. Western blot analysis of Fibulin-4 (arrow) in HepG2 cell line lysates (35ug/lane) using Fibulin-4  Antibody  (C-term). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-EFEMP2 Antibody Titration: 0.2-1 ug/mlPositive Control: NCI-H226 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB Western blot analysis of extracts from K562/NIH-3T3 cells, using EFEMP2 Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human placenta tissue, using EFEMP2 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of Fibulin 4 staining in HepG2 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of Fibulin 4 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB 100 μg Log in to see 11 to 16 Days
$412.86
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB EFEMP2 antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 3 to 4 Days
$473.93
Details
Human Rabbit FITC FACS, IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$385.00
Details

FBLN4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Fibulin 4 Antibodies

  1. Human Polyclonal FBLN4 Primary Antibody for EIA, FACS - ABIN952327 : Chen, Zhang, Roshetsky, Ouyang, Essers, Fan, Wang, Hinek, Plow, Dicorleto: Fibulin-4 regulates expression of the tropoelastin gene and consequent elastic-fibre formation by human fibroblasts. in The Biochemical journal 2009 (PubMed)
    Show all 3 references for ABIN952327

  2. Human Polyclonal FBLN4 Primary Antibody for FACS, WB - ABIN653217 : El-Hallous, Sasaki, Hubmacher, Getie, Tiedemann, Brinckmann, Bätge, Davis, Reinhardt: Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin. in The Journal of biological chemistry 2007 (PubMed)

More Antibodies against Fibulin 4 Interaction Partners

Human Fibulin 4 (FBLN4) interaction partners

  1. Data indicates that Fibulin-4 is a novel gene that is found overexpressed in ovarian cancer and associated with poor prognostic clinicopathologic features.

  2. pulmonary emphysema in aneurysmal Fibulin-4 deficient (Fibulin-4(R)) mice

  3. Homozygous mutations in exon 7 of the FBLN4 gene can produce lethal vasculopathy.

  4. This study demonstrated that fibulin-4 may serve as a new prognostic factor and as a potential therapeutic target for patients with cervical carcinoma.

  5. The expression level of EFEMP2 is dramatically increased in colorectal cancer patients, even at the early stage, compared with healthy controls.

  6. Studied Fibulin-4 expression in aortic wall to find out its role in aortic dissection development. Used samples of aortic wall from 10 patients operated for acute ascending aortic dissection and five patients for chronic ascending aortic dissection.

  7. Data indicate mutations of FBLN4, FBLN5 (show FBLN5 Antibodies), and LTBP4 (show LTBP4 Antibodies) in 12 probands presenting with type 1 recessive cutis laxa.

  8. A lethal, genetic disorder characterized by severe deformation of elastic arteries, was linked to novel mutations in the FBLN4 gene.

  9. Low EFEMP2 expression is associated with malignant pleural mesothelioma.

  10. EFEMP2 is a novel PITX2 (show PITX2 Antibodies)-interacting protein that may bear importance for the development of anterior segment dysgenesis (ASD (show ARSD Antibodies)) and glaucoma.

Mouse (Murine) Fibulin 4 (FBLN4) interaction partners

  1. These data provide new insights in the molecular interaction between Fibulin-4 and TGF-beta (show TGFB1 Antibodies) pathway regulation in the pathogenesis of aortic aneurysms.

  2. Fibulin-4 serves as a potential scaffolding protein during collagen maturation in the extracellular space and loss of fibulin-4 disrupts collagen synthesis and maturation.

  3. fibulin-4 plays a role in regulating collagen fibril assembly and offer a preclinical platform for developing treatments for autosomal recessive cutis laxa 1B.

  4. MBP1 (show ENO1 Antibodies) inhibits Ab fibril formation in vitro and demonstrate the ability of MBP1 (show ENO1 Antibodies) to reduce Ab pathology and improve behavioral performance.

  5. pulmonary emphysema in aneurysmal Fibulin-4 deficient (Fibulin-4(R)) mice

  6. Smooth muscle cell (SMC (show DYM Antibodies))-specific deletion of Fibulin-4 knockout ascending aorta and carotid artery showed mechanical changes in the axial direction.

  7. Compared to control SMCs, the modulus of Eln (show ELN Antibodies)-/- SMCs is reduced by 40%, but is unchanged in Fbln4-/- SMCs. The Eln (show ELN Antibodies)-/- SMC (show DYM Antibodies) modulus is rescued by soluble or alpha elastin (show ELN Antibodies) treatment.

  8. abnormal up-regulation of angiotensin-converting enzyme (ACE (show ACE Antibodies)) in SMCs and subsequent activation of angiotensin II (AngII) signaling are involved in the onset of aortic aneurysms in Fbln4 mice.

  9. Data show that fibulin-4 staining intensity in the ligamentum flavum was greatest at P14, though moderately strong at P7 and P21, and efore P7 and after P28, staining was detectable but relatively minimal.

  10. Data show that the structural and functional alterations were accompanied by upregulation of TGF-beta (show TGFB1 Antibodies) signaling in aortas from fibulin-4 deficient mice.

Fibulin 4 (FBLN4) Antigen Profile

Protein Summary

A large number of extracellular matrix proteins have been found to contain variations of the epidermal growth factor (EGF) domain and have been implicated in functions as diverse as blood coagulation, activation of complement and determination of cell fate during development. The protein encoded by this gene contains four EGF2 domains and six calcium-binding EGF2 domains. This gene is necessary for elastic fiber formation and connective tissue development. Defects in this gene are cause of an autosomal recessive cutis laxa syndrome. Alternatively spliced transcript variants have been identified for this gene.

Gene names and symbols associated with anti-Fibulin 4 (FBLN4) Antibodies

  • EGF-containing fibulin-like extracellular matrix protein 2 (Efemp2) antibody
  • EGF containing fibulin-like extracellular matrix protein 2b (efemp2b) antibody
  • fibulin 4 (fbln4) antibody
  • EGF containing fibulin-like extracellular matrix protein 2 (EFEMP2) antibody
  • epidermal growth factor-containing fibulin-like extracellular matrix protein 2 (Efemp2) antibody
  • 0610011K11Rik antibody
  • ARCL1B antibody
  • CB257 antibody
  • Fbln4 antibody
  • fc56c09 antibody
  • FIBL-4 antibody
  • Fibulin-4 antibody
  • H411 antibody
  • id:ibd2923 antibody
  • MBP1 antibody
  • sb:cb257 antibody
  • UPH1 antibody
  • wu:fc56c09.x1 antibody

Protein level used designations for anti-Fibulin 4 (FBLN4) Antibodies

fibulin 4 , EGF-containing fibulin-like extracellular matrix protein 2 , FIBL-4 , fibulin-4 , mutant p53 binding protein 1 , EGF-containing fibulin-like extracellular matrix protein 2 (Efemp2) , mutant p53-binding protein 1 , Protein H411

GENE ID SPECIES
293677 Rattus norvegicus
572703 Danio rerio
100195030 Salmo salar
30008 Homo sapiens
58859 Mus musculus
100736553 Cricetulus griseus
Selected quality suppliers for anti-Fibulin 4 (FBLN4) Antibodies
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