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The protein encoded by FBLN5 is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. Additionally we are shipping Fibulin 5 Antibodies (134) and Fibulin 5 Kits (29) and many more products for this protein.
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Human Fibulin 5 Protein expressed in Human - ABIN2721183
Sideek, Menz, Parsi, Gibson: LTBP-2 competes with tropoelastin for binding to fibulin-5 and heparin, and is a negative modulator of elastinogenesis. in Matrix biology : journal of the International Society for Matrix Biology 2014
We also found that Fibulin-5 reduces the level of expression of Ki-67 (show MKI67 Proteins), a nuclear protein (show RDBP Proteins) associated with cell proliferation. Moreover, reduction in Fibulin-5 expression corresponds to an increase of Ki-67 (show MKI67 Proteins) detection in breast tissue samples
study demonstrates the pivotal role of the extracellular protein, fibulin-5, on the adhesion and proliferation of human keloid-derived cells, through binding to integrin beta-1 (show ITGB1 Proteins)
Lower FBLN-5 expression is an important indicator of poor survival in hepatocellular carcinoma. FBLN-5 inhibits HCC (show FAM126A Proteins) adhesion/motility via integrin-dependent mechanism.
FBLN5 mRNA expression is upregulated in response to cAMP-mediated decidualization of primary human endometrial stromal cells, although FBLN5 itself does not enhance decidualization
Fibulin-5 is significantly down-regulated in ovarian carcinoma and acts as a tumour suppressor by inhibiting the migration and invasion of ovarian cancer cells.
Data indicate that Fbln5 promotes PDAC progression by functioning as a molecular rheostat that modulates cell-ECM (show MMRN1 Proteins) interactions to reduce ROS (show ROS1 Proteins) production, and thus tip the balance in favor of tumor cell survival and treatment-refractory disease.
Data suggest that fibulin-5 functions as a metastasis suppressor in lung cancer by modulating tumor microenvironment to suppress Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.
Fibulin-5 may be implicated in the aetiology of rectal prolapse in a subgroup of young male patients.
Fibulin-5 expression is a disease marker of hepatic fibrosis.
Loss of FBLN5 expression is associated with glioma.
While premaxillo-maxillary suture mesenchymal cells in fibulin-5-null mice were capable of differentiating into osteoblasts, suture cells in mutant mice were less proliferative.
Fibulin-5 plays critical roles in proliferation, migration and invasion of certain tumors, and the effect of fibulin-5 on tumorigenesis appears to be largely context-dependent. (Review)
These results are consistent with a role for TGFbeta2 in lung septation and for Ltbp4 in regulating fibulin-5 dependent elastic fiber assembly.
Without LTBP-4, fibulin-5 and tropoelastin (show ELN Proteins) deposition was discontinuous and punctate in vitro and in vivo
This study used the maturation of fibulin-5 knockout (KO) and wild-type mice to study the effects of fragmented elastic fibers on the growth and remodeling of carotid arteries.
suggest that uPA (show PLAU Proteins) promotes cell migration by binding to fibulin-5, initiating its cleavage by plasmin (show PLG Proteins), which leads to its dissociation from beta1-integrin and thereby unblocks the capacity of integrin to facilitate cell motility
MMP9 (show MMP9 Proteins) and fibulin-5 have roles in progression of pelvic organ prolapse in mice and humans
mechanical testing and confocal imaging of common carotid arteries from fibulin-5 null mice and littermate controls to characterize the mechanical behavior and microstructural content of these arteries
These findings introduce a novel function for Fbln5 in the regulation of integrin-induced reactive oxygen species production.
These results suggest a novel regulatory mechanism of elastic fiber assembly in which LTBP-2 (show LTBP2 Proteins) regulates targeting of DANCE on suitable microfibrils to form elastic fibers.
The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3).
, fibulin 5
, developmental arteries and neural crest EGF-like protein
, urine p50 protein
, embryonic vascular EGF repeat-containing protein