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Fizzy/cell Division Cycle 20 Related 1 (Drosophila) Proteins (FZR1)

Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Additionally we are shipping FZR1 Antibodies (65) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat FZR1 FZR1 314642  
FZR1 51343 Q9UM11
FZR1 56371 Q9R1K5
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Top FZR1 Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

FZR1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)
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More Proteins for Fizzy/cell Division Cycle 20 Related 1 (Drosophila) (FZR1) Interaction Partners

Pig (Porcine) Fizzy/cell Division Cycle 20 Related 1 (Drosophila) (FZR1) interaction partners

  1. porcine FZR1 and CDC20 (show CDC20 Proteins) work on the maintenance of meiotic arrest at the first meiotic prophase and on the exit from M1

Human Fizzy/cell Division Cycle 20 Related 1 (Drosophila) (FZR1) interaction partners

  1. Cdh1 (show CDH1 Proteins) contributes to spatiotemporal organization of AurB (show AURKB Proteins) activity, and organization of FHOD1 (show FHOD1 Proteins) activity by AurB (show AURKB Proteins) contributes to daughter cell spreading after mitosis.

  2. Anaphase-promoting complex/cyclosome-CDH1 (show CDH1 Proteins), rather than Cdc20 (show CDC20 Proteins), promotes the degradation of BRSK2 (show BRSK2 Proteins) in vivo.

  3. Anaphase-promoting complex/cyclosome-Cdh1 (show CDH1 Proteins) coordinates glycolysis and glutaminolysis with transition to S phase in human T lymphocytes.

  4. Cdh1-depleted H (show CDH1 Proteins)eLa cells reduced s (show CDH1 Proteins)tress (show FABP6 Proteins)fiber formation significantly. The GTP-bound active Rho protein was apparently decreased in the Cdh1-depleted cells.

  5. FZR1 is not required for the completion of mitosis, but is an important regulator of G1 phase and is required for efficient DNA replication in human and mouse somatic cells.

  6. Destruction-box specificities of APC (show APC Proteins)/C(fzy) and APC (show APC Proteins)/C(fzr)& successive activation of APC (show APC Proteins)/C by fzy & fzr establish the temporal substrate degradation pattern, explaining why some endogenous RXXL substrates are degraded by fzy & others by fzr complexes.

  7. Results indicate that Cdh1 (show CDH1 Proteins) mediates its own degradation by activating the anaphase-promoting complex/cyclosome to degrade itself.

  8. Data show that degradation of TMAP/CKAP2 (show CKAP2 Proteins) during mitotic exit is mediated by the anaphase-promoting complex bound to Cdh1 (show CDH1 Proteins) and that the KEN box motif near the N terminus is necessary for its destruction.

  9. Retinoic acid downregulates Rae1 (show RAE1 Proteins), hence facilitating APC (show APC Proteins)(Cdh1 (show CDH1 Proteins))-mediated Skp2 degradation leading to the arrest of cell cycle progression and neuroblastoma (show ARHGEF16 Proteins) differentiation.

  10. during endocycles, APC (show APC Proteins)/C Fzr/Cdh1 functions to reduce the levels of the mitotic cyclins and Geminin (show GMNN Proteins) in order to facilitate the relicensing of DNA replication origins and cell cycle progression

Mouse (Murine) Fizzy/cell Division Cycle 20 Related 1 (Drosophila) (FZR1) interaction partners

  1. Both catalytic and non-catalytic APC (show APC Proteins)/C-Fzr1/Cdh1-mediated activities of PTEN are required for stalk cells' proliferative arrest. Findings implicate the PTEN-APC (show APC Proteins)/C-Fzr1/Cdh1 hub in angiogenesis.

  2. Loss of APC (show APC Proteins)/C(FZR1) activity in the male germline led to both a mitotic and a meiotic testicular defect resulting in infertility due to the absence of mature spermatozoa.

  3. Fzr1 is a surprisingly essential gene involved in the establishment of a single spindle from the two pronuclei in 1-cell embryos as well as being involved in the maintenance of genomic integrity during the mitotic divisions of early mammalian embryos.

  4. This study implicates FZR1 as a major regulator of prometaphase whose activity helps to prevent chromosome nondisjunction.

  5. When a neuronal cell enters S phase, Cdk5 (show CDK5 Proteins) is transported to the cytoplasm where it is ubiquitinated by the E3 ligase APC (show APC Proteins)-Cdh1 (show CDH1 Proteins)

  6. Cdh1 (show CDH1 Proteins)-APC (show APC Proteins) appears to play a role in regulating axonal growth and patterning in the developing brain that may also limit the growth of injured axons in the adult brain.

  7. FZR1 activity is required to repress cyclin B1 (show CCNB1 Proteins) levels in oocytes during prophase I arrest in the ovary, thereby maintaining meiotic quiescence until hormonal cues trigger resumption

  8. homozygous Cdh1 (show CDH1 Proteins) gene-trapped (Cdh1 (show CDH1 Proteins)(GT/GT (show FABP6 Proteins)))embryonic fibroblasts reduced stress fiber formation significantly

  9. These results indicate that Cdh1 (show CDH1 Proteins) is required for preventing unscheduled proliferation of specific progenitor cells and protecting mammalian cells from genomic instability.

  10. Depletion of FZR1 (CDH1), a regulatory subunit of the anaphase-promoting complex/cyclosome that targets cyclin B1 (CCNB1 (show CCNB1 Proteins)) for ubiquitin-mediated proteolysis, partially restores normal timing of meiotic resumption in oocytes with excess CDC14B (show CDC14B Proteins).

FZR1 Protein Profile

Protein Summary

Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage leads to the ubiquitination of PLK1, preventing entry into mitosis (By similarity).

Gene names and symbols associated with FZR1

  • fizzy/cell division cycle 20 related 1 (Drosophila) (Fzr1)
  • fizzy/cell division cycle 20 related 1 (Drosophila) (FZR1)
  • fizzy-related protein homolog-like (LOC100179951)
  • fizzy/cell division cycle 20 related 1 (Drosophila) (fzr1)
  • AW108046 protein
  • CDC20C protein
  • Cdh1 protein
  • CDH1-C protein
  • Fyr protein
  • FZR protein
  • fzr1 protein
  • FZR2 protein
  • HCDH protein
  • HCDH1 protein
  • zgc:55450 protein

Protein level used designations for FZR1

fizzy-related protein homolog , fizzy/cell division cycle 20 related 1 (Drosophila) , fizzy-related protein FZR , Fizzy-related protein-like protein , fizzy/cell division cycle 20 related 1 , CDC20-like 1b , CDC20-like protein 1 , cdh1/Hct1 homolog , cell division cycle 20 related 1

GENE ID SPECIES
314642 Rattus norvegicus
373959 Gallus gallus
485059 Canis lupus familiaris
497234 Sus scrofa
530333 Bos taurus
721711 Macaca mulatta
100027495 Monodelphis domestica
100061287 Equus caballus
100179951 Ciona intestinalis
100389263 Callithrix jacchus
100586451 Nomascus leucogenys
51343 Homo sapiens
56371 Mus musculus
393223 Danio rerio
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