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Flavin Containing Monooxygenase 1 Proteins (FMO1)

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Additionally we are shipping FMO1 Antibodies (16) and FMO1 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FMO1 14261 P50285
FMO1 25256 P36365
FMO1 2326 Q01740
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Top FMO1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,514.50
Details

FMO1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human ,
,

More Proteins for Flavin Containing Monooxygenase 1 (FMO1) Interaction Partners

Mouse (Murine) Flavin Containing Monooxygenase 1 (FMO1) interaction partners

  1. Data indicate that in contrast to FMO2 (show FMO2 Proteins) and FMO4 (show FMO4 Proteins), FMO1 is highly expressed in metabolic tissues, including liver, kidney, white adipose tissue (WAT) and brown adipose tissue (BAT (show BAAT Proteins)).

  2. Fmo1, 2, 3, 4 and 5 exhibit distinct cell-, tissue-, sex- and developmental stage-specific patterns of expression.

  3. The functional activity of Fmo1 was determined.

  4. Deletion of the mouse Fmo1 gene results in enhanced pharmacological behavioral responses to imipramine.

Human Flavin Containing Monooxygenase 1 (FMO1) interaction partners

  1. data support the role of FMO3 (show FMO3 Proteins) in the N-oxidation of OLA and implicate for the first time the contribution of FMO1 and its functional *6 variant in OLA disposition

  2. polymorphisms in FMO1 are significant risk factors in the development of nicotine dependence and that the mechanism may involve variation in nicotine pharmacology.

  3. The results of this study suggested that the alteration of FMO gene expression is a consequence of the pathological environment linked to oxidative stress related to mutated SOD1 (show SOD1 Proteins).

  4. FMO1 expression is restricted to the fetus; FMO1 suppression occurred within 3 d postpartum in a process tightly coupled to birth, but not gestational age.

  5. data from transient expression assays in HepG2 cells suggested this SNP could account for a 2- to 3-fold loss of FMO1 promoter activity.

  6. "...in fetal liver, where FMO1 predominates attaining expression levels of (about) 32% of expressed CYP3A4 (show CYP3A4 Proteins)." p. 574 "...recent examples indicate that FMOs play a prominent role in the metabolism ...of important drugs." p. 575

  7. FMO1 was found to be down-regulated in human adult brain tissue.

  8. Early studies described in this review document that FMO1 is the most abundant FMO enzyme in the human fetal liver, whereas FMO3 (show FMO3 Proteins) is essentially absent.

  9. Specific allelic variants of the FMO1 gene might be associated to susceptibility to develop ALS.

  10. The resulting data showed that N,N-dimethylamphetamine N-oxidation is mainly mediated by FMO1.

FMO1 Protein Profile

Protein Summary

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics.

Gene names and symbols associated with FMO1

  • flavin containing monooxygenase 1 (FMO1)
  • flavin containing monooxygenase 1 (fmo1)
  • flavin containing monooxygenase 1 (Fmo1)
  • RFMO1A protein

Protein level used designations for FMO1

flavin containing monooxygenase 1 , dimethylaniline monooxygenase [N-oxide-forming] 1 , FMO 1 , dimethylaniline oxidase 1 , hepatic flavin-containing monooxygenase 1 , Flavin-containing monooxygenase 1 , Flavin-containing monooxygenase 1 (fetal liver) , fetal hepatic flavin-containing monooxygenase 1 , flavin-containing monooxygenase 1 , hepatic flavin-containing monooxygenase (FMO) , FMO 1A1 , FMO form 1

GENE ID SPECIES
456444 Pan troglodytes
508781 Bos taurus
549120 Xenopus (Silurana) tropicalis
100173722 Pongo abelii
14261 Mus musculus
25256 Rattus norvegicus
2326 Homo sapiens
403604 Canis lupus familiaris
100723945 Cavia porcellus
397132 Sus scrofa
100009120 Oryctolagus cuniculus
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