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Flavin Containing Monooxygenase 3 Proteins (FMO3)

Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. Additionally we are shipping FMO3 Antibodies (75) and FMO3 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FMO3 2328 P31513
FMO3 14262 P97501
FMO3 84493 Q9EQ76
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Top FMO3 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,510.83
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

FMO3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Flavin Containing Monooxygenase 3 (FMO3) Interaction Partners

Human Flavin Containing Monooxygenase 3 (FMO3) interaction partners

  1. Oxidative stress-responsive transcription factor NRF2 (show GABPA Proteins) is not indispensable for the human hepatic Flavin-containing monooxygenase-3 (FMO3) gene expression in HepG2 cells

  2. FMO3 gene polymorphism E158K is a significant predictor of predisposition to chronic heart disease in women.

  3. FMO3 is centrally involved in the pathogenesis of atherosclerosis by regulating cholesterol metabolism and insulin (show INS Proteins) resistance. [Review]

  4. FMO3 expression is increased in ob (show INS Proteins)ese/insulin resistant patients.

  5. These results suggest that genetic polymorphism in the human FMO3 gene may lead to changes of drug interactions for N- or S-oxygenations of xenobiotics and endogenous substances.

  6. Effect of two-linked mutations of the FMO3 gene on itopride metabolism in Chinese healthy volunteers

  7. Three polymorphisms were found in intronic regions of FMO3 in a child with trimethylaminuria and in her parents and a brother. The parents and brother showed no symptoms.

  8. Comparisons of genotype and phenotype reveal that severe trimethylaminuria is caused by loss of function mutations in FMO3

  9. results show that FMO3 E158K and POR (show POR Proteins) A503V polymorphisms are minor sources of nicotine metabolism variation, insufficient to appreciably alter smoking.

  10. CYP3A4 (show CYP3A4 Proteins) and FMO3 are the major enzymes responsible for the metabolism of teneligliptin in humans.

Cow (Bovine) Flavin Containing Monooxygenase 3 (FMO3) interaction partners

  1. Fishy off-flavor in cow's milk is caused by a nonsense mutation (R238X) in FMO3, found to be surprisingly common (q = 0.155) in the Swedish Red and White breed of dairy cattle.

Mouse (Murine) Flavin Containing Monooxygenase 3 (FMO3) interaction partners

  1. FMO3 is increased in obese/insulin (show INS Proteins) resistant male mice and necessary for expression of FoxO1 (show FOXO1 Proteins).

  2. Fmo3 expression and function plays a role in protecting the liver from acetaminophen-induced toxicity.

  3. a major role for FMO3 in modulating glucose and lipid homeostasis

  4. Report temporal changes in hepatic Fmo3 gene expression under different conditions all known to cause hepatic oxidative stress.

  5. Report selective modulation of hepatic cytochrome P450 and flavin monooxygenase 3 expression during citrobacter rodentium infection in SCID (show PRKDC Proteins) mice.

  6. The functional activity of Fmo3 was determined.

FMO3 Protein Profile

Protein Summary

Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.

Gene names and symbols associated with FMO3

  • flavin containing monooxygenase 3 (FMO3)
  • flavin containing monooxygenase 3 (fmo3)
  • flavin containing monooxygenase 3 (Fmo3)
  • AW111792 protein
  • dJ127D3.1 protein
  • FM03 protein
  • FMOII protein
  • MGC107820 protein
  • TMAU protein

Protein level used designations for FMO3

dimethylaniline monooxygenase [N-oxide-forming] 3 , flavin containing monooxygenase 3 , FMO 3 , FMO II , FMO form 2 , dimethylaniline oxidase 3 , hepatic flavin-containing monooxygenase 3 , hepatic flavin-containing monooxygenase-3 , trimethylamine monooxygenase , flavin-containing monooxygenase 3 , FMO 1D1 , flavin-containing monooxygenase FMO3 , flavin-containing monooxygenase form 3

GENE ID SPECIES
100171678 Pongo abelii
548424 Xenopus (Silurana) tropicalis
447265 Xenopus laevis
2328 Homo sapiens
403603 Canis lupus familiaris
281167 Bos taurus
100009065 Oryctolagus cuniculus
14262 Mus musculus
84493 Rattus norvegicus
457505 Pan troglodytes
574244 Macaca mulatta
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