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Flightless I Homolog (Drosophila) Proteins (FLII)

FLII encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. Additionally we are shipping Flightless I Homolog (Drosophila) Antibodies (30) and Flightless I Homolog (Drosophila) Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FLII 2314 Q13045
FLII 14248 Q9JJ28
Rat FLII FLII 287375  
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Top Flightless I Homolog (Drosophila) Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
Yeast Mouse His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details

FLII Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Mouse (Murine) ,

More Proteins for Flightless I Homolog (Drosophila) (FLII) Interaction Partners

Zebrafish Flightless I Homolog (Drosophila) (FLII) interaction partners

  1. Embryos defective in flightless I homolog (flii), which encodes for an actin-regulating protein, exhibit normal coilings at 24 hours post fertilization (hpf) that is followed by significantly slower burst swimming at 48 hpf.

Human Flightless I Homolog (Drosophila) (FLII) interaction partners

  1. These data suggest FLII as a key regulator of ERalpha-mediated transcription through its role in regulating chromatin accessibility for the binding of RNA Polymerase II and possibly other transcriptional coactivators.

  2. Flii is constitutively secreted from macrophages and fibroblasts and is present in human plasma.

  3. The mouse (Fli1 (show FLI1 Proteins)) and human Fli1 (show FLI1 Proteins) genes are similarly regulated by Ets (show ETS1 Proteins) factors in T cells.

  4. Fli-I promotes the GTP-bound active Rho-mediated relief of the autoinhibition of Daam1 and mDia1. Thus, Fli-I is a novel positive regulator of Rho-induced linear actin assembly mediated by DRFs.

  5. These data suggest that Flightless-I may facilitate interaction of the p160 coactivator complex with other coactivators or coactivator complexes containing actin or actin-like proteins.

  6. The gene that was most reproducibly up-regulated by EWS (show EWSR1 Proteins)/FLI was NR0B1 (show NR0B1 Proteins).

  7. effect of FliI protein on actin remodelling is a vital part of cellular motility, contraction and adhesion. Exact signaling pathways and mechanisms underpinning FliI effects in wound healing are yet to be fully identified[review]

  8. These findings support a novel mechanism whereby cytosolic CaMK-II influences beta-catenin dependent gene expression through Fli-I.

  9. The interactions between MyD88 (show MYD88 Proteins) and multiple positive and negative regulators LRRFIP2 (show LRRFIP2 Proteins), FLAP-1 (show LRRFIP1 Proteins), and Fliih are highly dynamic and time-course dependent in differentially regulating/modulating NF-kappa B (show NFKB1 Proteins) signal transduction.

  10. These findings support the model that CISK phosphorylates FLII and activates nuclear receptor transcription and suggest a new cell survival signaling pathway mediated by PI 3 (show PI3 Proteins)-kinase and CISK.

Mouse (Murine) Flightless I Homolog (Drosophila) (FLII) interaction partners

  1. P-Rex1 stimulates migration through enhancing the interaction between Rac1 and the actin-remodelling protein.

  2. Genes downstream from Flii, including TGF-beta1 (show TGFB1 Proteins) and TGF-beta3 (show TGFB3 Proteins), showed significantly altered expression confirming a functional effect of the Rhodamine-Flii small interfering RNA on gene expression

  3. FliI interacts with NMMIIA to promote cell extension formation, which enables collagen remodeling in fibroblasts.

  4. FLII functions in PPARgamma (show PPARG Proteins) activation as a molecular switch to repress transcriptional activity by interrupting formation of the PPARgamma (show PPARG Proteins)/RXRalpha (show RXRA Proteins) complex.

  5. LRRFIP2 (show LRRFIP2 Proteins) inhibits NLRP3 (show NLRP3 Proteins) inflammasome activation by recruiting the caspase-1 (show CASP1 Proteins) inhibitor Flightless-I, thus outlining a new mechanism for negative regulation of NLRP3 (show NLRP3 Proteins) inflammasome.

  6. increasing the level of Flii in diabetic mouse wounds led to increased TLR4 (show TLR4 Proteins) and NF- kappa B (show NFKB1 Proteins) production. Treatment of murine diabetic wounds with neutralising antibodies to Flii led to an improvement in healing with decreased expression of TLR4 (show TLR4 Proteins)

  7. Using a mouse model of epidermolysis bullosa acquisita, the effect of "mopping up" Flii using Flii-neutralizing antibodies before, during, and after blister formation was determined.

  8. Flii is constitutively secreted from macrophages and fibroblasts and is present in human plasma.

  9. FliI regulates cell migration through its localization to focal adhesions and its ability to cap actin filaments, which collectively affect focal adhesion maturation.

  10. Data show that mice with elevated Flii expression exhibit impaired wound healing.

Caenorhabditis elegans (C. elegans) Flightless I Homolog (Drosophila) (FLII) interaction partners

  1. fli-1 plays an important role in regulating the actin-dependent events during C. elegans development.

  2. FLI-1 controls germ line morphogenesis and rachis organization

Flightless I Homolog (Drosophila) (FLII) Protein Profile

Protein Summary

This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17.

Gene names and symbols associated with FLII

  • flightless I homolog (Drosophila) (FLII)
  • flightless I homolog (Drosophila) (flii)
  • protein flightless-1 homolog (LOC100051793)
  • protein flightless-1 homolog (LOC100398338)
  • protein flightless-1 homolog (LOC100619473)
  • protein flightless-1 homolog (LOC100640615)
  • flightless 1 homolog (flii)
  • flightless I homolog (Drosophila) (Flii)
  • Protein FLI-1 (fli-1)
  • 3632430F08Rik protein
  • DKFZp459O043 protein
  • FLI protein
  • Fli1 protein
  • flightless protein
  • Fliih protein
  • FLIL protein
  • im:7141769 protein

Protein level used designations for FLII

flightless I homolog (Drosophila) , flightless-I homolog , protein flightless-1 homolog

GENE ID SPECIES
454486 Pan troglodytes
479521 Canis lupus familiaris
514446 Bos taurus
560281 Danio rerio
585336 Strongylocentrotus purpuratus
700471 Macaca mulatta
723252 Macaca mulatta
100051793 Equus caballus
100173989 Pongo abelii
100398338 Callithrix jacchus
100475330 Ailuropoda melanoleuca
100543687 Meleagris gallopavo
100553018 Anolis carolinensis
100600354 Nomascus leucogenys
100619473 Monodelphis domestica
100640615 Amphimedon queenslandica
444748 Xenopus laevis
416515 Gallus gallus
2314 Homo sapiens
14248 Mus musculus
287375 Rattus norvegicus
176215 Caenorhabditis elegans
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