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FLII encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. Additionally we are shipping Flightless I Homolog (Drosophila) Antibodies (31) and Flightless I Homolog (Drosophila) Proteins (4) and many more products for this protein.
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Flightless-I (Drosophila) homolog (FLII) activates TGFbeta1 (show TGFB1 ELISA Kits)-mediated expression of COL1A2 (show COL1A2 ELISA Kits) gene.
Studies suggest that Flii enhances cutaneous squamous cell carcinoma progression by decreasing apoptosis and enhancing tumor cell invasion.
FLII plays a tumor-suppressive role and serves as a crucial determinant of resistance of prostate cancer to endocrine therapies.
These data suggest FLII as a key regulator of ERalpha-mediated transcription through its role in regulating chromatin accessibility for the binding of RNA Polymerase II and possibly other transcriptional coactivators.
Flii is constitutively secreted from macrophages and fibroblasts and is present in human plasma.
The mouse (Fli1 (show FLI1 ELISA Kits)) and human Fli1 (show FLI1 ELISA Kits) genes are similarly regulated by Ets (show ETS1 ELISA Kits) factors in T cells.
Fli-I promotes the GTP-bound active Rho-mediated relief of the autoinhibition of Daam1 and mDia1. Thus, Fli-I is a novel positive regulator of Rho-induced linear actin assembly mediated by DRFs.
These data suggest that Flightless-I may facilitate interaction of the p160 coactivator complex with other coactivators or coactivator complexes containing actin or actin-like proteins.
The gene that was most reproducibly up-regulated by EWS (show EWSR1 ELISA Kits)/FLI was NR0B1 (show NR0B1 ELISA Kits).
effect of FliI protein on actin remodelling is a vital part of cellular motility, contraction and adhesion. Exact signaling pathways and mechanisms underpinning FliI effects in wound healing are yet to be fully identified[review]
Flii genetic expression is enhances tissue regeneration, after claw amputation.
P-Rex1 stimulates migration through enhancing the interaction between Rac1 and the actin-remodelling protein.
Genes downstream from Flii, including TGF-beta1 (show TGFB1 ELISA Kits) and TGF-beta3 (show TGFB3 ELISA Kits), showed significantly altered expression confirming a functional effect of the Rhodamine-Flii small interfering RNA on gene expression
FliI interacts with NMMIIA to promote cell extension formation, which enables collagen remodeling in fibroblasts.
FLII functions in PPARgamma (show PPARG ELISA Kits) activation as a molecular switch to repress transcriptional activity by interrupting formation of the PPARgamma (show PPARG ELISA Kits)/RXRalpha (show RXRA ELISA Kits) complex.
LRRFIP2 (show LRRFIP2 ELISA Kits) inhibits NLRP3 (show NLRP3 ELISA Kits) inflammasome activation by recruiting the caspase-1 (show CASP1 ELISA Kits) inhibitor Flightless-I, thus outlining a new mechanism for negative regulation of NLRP3 (show NLRP3 ELISA Kits) inflammasome.
increasing the level of Flii in diabetic mouse wounds led to increased TLR4 (show TLR4 ELISA Kits) and NF- kappa B (show NFKB1 ELISA Kits) production. Treatment of murine diabetic wounds with neutralising antibodies to Flii led to an improvement in healing with decreased expression of TLR4 (show TLR4 ELISA Kits)
Using a mouse model of epidermolysis bullosa acquisita, the effect of "mopping up" Flii using Flii-neutralizing antibodies before, during, and after blister formation was determined.
These findings strongly demonstrate that the three single nucleotide polymorphisms of FLII gene could be utilized as molecular markers for future assisted selection in cattle breeding program.
Embryos defective in flightless I homolog (flii), which encodes for an actin-regulating protein, exhibit normal coilings at 24 hours post fertilization (hpf) that is followed by significantly slower burst swimming at 48 hpf.
fli-1 plays an important role in regulating the actin-dependent events during C. elegans development.
FLI-1 controls germ line morphogenesis and rachis organization
This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17.
protein flightless-1 homolog
, flightless I homolog (Drosophila)
, flightless-I homolog
, flightless I homolog