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Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. Additionally we are shipping Flotillin 1 Antibodies (73) and Flotillin 1 Kits (8) and many more products for this protein.
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Flotillin-1 regulates ephrinB2 (show EFNB2 Proteins) protein levels through ADAM10 (show ADAM10 Proteins), and is required for appropriate neural tube morphogenesis in the Xenopus embryo.
At late tail bud stages, flotillin1A is expressed in branchial arch mesenchyme, the overlying branchial ectoderm and in dorsal somitic mesoderm, whereas flotillin1B expression is more restricted in the dorsal neural tube and head sensory structures.
Data show that overexpression of 4.1N (show EPB41L1 Proteins) protein decreased expression of flotillin-1, decreased activation of beta-catenin (show CTNNB1 Proteins)/Wnt (show WNT2 Proteins) pathway in non-small-cell lung cancer (NSCLC) cells.
Upregulation of flotillin-1 promotes invasion and metastasis by activating TGF-beta (show TGFB1 Proteins) signaling in nasopharyngeal carcinoma.
Flotillin-1 protein is upregulated in human endometrial cancer and localization shifts from epithelial to stromal with increasing tumor grade
Expression of flotillin-1 was associated with H-Ras (show HRAS Proteins) in breast cancer, especially in TNBC (p < 0.001).
findings revealed the expression of flotillin 1 in gastric cancer samples is significantly higher than that of noncancer/normal tissues; findings suggest that flotillin 1 may be a novel biomarker for gastric cancer
miR (show MLXIP Proteins)-506 expression was down-regulated in clear cell renal cell carcinoma (show MOK Proteins) (ccRCC) and correlated with advanced histologic grade, clinical stage, tumor stage, positive lymph node metastasis, and distant metastasis. FLOT1, a potential target gene of miR (show MLXIP Proteins)-506, was inversely correlated with miR (show MLXIP Proteins)-506 expression in ccRCC tissues.
polycystins are necessary for assembly of a novel flotillin (show FLOT2 Proteins)-containing ciliary signaling complex and provide a molecular rationale for the common renal pathologies caused by OFD1 (show OFD1 Proteins) and polycystin mutations.
Findings suggest that FLOT1 plays an important role in the proliferation and recurrence of transitional cell carcinoma.
Downregulation of microRNA-182-5p contributes to renal cell carcinoma (show MOK Proteins) proliferation via activating the AKT (show AKT1 Proteins)/FOXO3a (show FOXO3 Proteins) signaling pathway with FLOT1 being a target.
overexpression of FLOT1 can be found in tongue squamous cell cancer patients with higher pathological stage, T classification, N classification or recurrence
The role of flotillin 1 and flotillin 2 (show FLOT2 Proteins) in regulating amyloid beta production in a mouse model of cerebral amyloidosis, remains unlear.
elevated levels of Flotillin-1 in hippocampal tissue of mice trained in the Morris water maze confirmed the relevance of Flotillin-1 for memory-related processes in a mammalian system.
a novel signaling network containing FRS2 (show FRS2 Proteins), CAP and flotillin-1
flotillins have a role in NPC1L1 (show NPC1L1 Proteins)-mediated cholesterol uptake and NPC1L1 (show NPC1L1 Proteins)-flotillins-postive cholesterol-enriched membrane microdomains are involved in the mechanism for efficient cholesterol absorption
Data suggest that the association between flotillin 1/2 microdomains and cortical cytoskeleton has important functions during neutrophil migration, in uropod formation, and in the regulation of myosin IIa.
LGI3 (show LGI3 Proteins) interacts with Flo1 in the brain, and LGI3 (show LGI3 Proteins)/Flo1 mediates APP (show APP Proteins) trafficking and exosome formation in neuronal cells: reveals the details of the intracellular transport system and even the secretion pathway in the brain.
Flotillin-1 and caveolin-3 (show CAV3 Proteins) may regulate muscle energy metabolism through the spatial and temporal segregation of key components of the insulin (show INS Proteins) signaling, including GLUT4 (show SLC2A4 Proteins) transport.
Analysis of reggie mRNA and protein expression patterns during early zebrafish development revealed that re-1a mRNA is present at high levels in expression domains that overlap with the combined expression pattern of both re-2 (show GPR161 Proteins) genes except at the somites.
Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. FLOT1 encodes a caveolae-associated, integral membrane protein. The function of flotillin 1 has not been determined.
, flotillin 1c
, flotillin 1a
, integral membrane component of caveolae
, flotillin 1