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Folliculin Proteins (FLCN)

FLCN is located within the Smith-Magenis syndrome region on chromosome 17. Additionally we are shipping FLCN Antibodies (82) and FLCN Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FLCN 216805 Q8QZS3
FLCN 303185 Q76JQ2
FLCN 201163 Q8NFG4
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Top FLCN Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,663.00
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

FLCN Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human , ,
,

More Proteins for Folliculin (FLCN) Interaction Partners

Mouse (Murine) Folliculin (FLCN) interaction partners

  1. mTOR (show FRAP1 Proteins) inhibitor, sirolimus, suppresses the tumor's growth, suggesting that mTOR (show FRAP1 Proteins) inhibitors might be effective in control of FLCN-deficient RCC (show XRCC1 Proteins).

  2. we show that glycogen (show GYS1 Proteins) accumulates in kidneys from mice lacking FLCN and in renal tumors from a BHD patient

  3. Fnip1 and Fnip2 (show FNIP2 Proteins) play critical roles in kidney tumor suppression in cooperation with Flcn

  4. Folliculin (Flcn) inactivation leads to murine cardiac hypertrophy through mTORC1 deregulation.

  5. The FLCN-GABARAP (show GABARAP Proteins) association is modulated by the presence of either folliculin-interacting protein (FNIP)-1 or FNIP2 (show FNIP2 Proteins) and further regulated by ULK1 (show ULK1 Proteins).

  6. Flcn regulates apoptosis in lung epithelium via E-cadherin (show CDH1 Proteins)-LKB1 (show STK11 Proteins)-AMPK (show PRKAA1 Proteins) axis.

  7. loss of FLCN constitutively activates AMPK (show PRKAA1 Proteins), resulting in PGC-1alpha-mediated mitochondrial biogenesis and increased ROS (show ROS1 Proteins) production

  8. These data support a model in which dysregulation of the FLCN-p0071 (show PKP4 Proteins) interaction leads to alterations in cell adhesion, cell polarity, and RhoA (show RHOA Proteins) signaling.

  9. FLCN deficiency and subsequent increased PPARGC1A expression result in increased mitochondrial function and oxidative metabolism as the source of cellular energy, which may drive hyperplastic transformation.

  10. The involvement of the AMPK (show PRKAA1 Proteins)-MAPO1 (show FNIP2 Proteins)-FLCN complex in the signaling pathway of apoptosis, is described.

Human Folliculin (FLCN) interaction partners

  1. We identified a hitherto unreported pathogenic FLCN frameshift deletion c.563delT (p.Phe188Serfs*35) in a family of a 46-year-old woman presented with macrohematuria due to bilateral chromophobe renal carcinomas

  2. FLCN irregulation in lung cysts of primary spontaneous pneumothorax is not associated with promoter methylation.

  3. mTOR (show FRAP1 Proteins) inhibitor, sirolimus, suppresses the tumor's growth, suggesting that mTOR (show FRAP1 Proteins) inhibitors might be effective in control of FLCN-deficient RCC (show XRCC1 Proteins).

  4. we show that glycogen (show GYS1 Proteins) accumulates in kidneys from mice lacking FLCN and in renal tumors from a BHD patient

  5. Case Report: FLCN deletion mutation in members of Indian Birt-Hogg-Dube syndrome family.

  6. This report documents the first identification of founder mutations in FLCN, as well as expands mutation spectrum of the gene

  7. FLCN-related renal cell carcinomas showed overexpression of GPNMB and underexpression of FLCN, whereas sporadic tumors showed inverted patterns.

  8. The FLCN-GABARAP (show GABARAP Proteins) association is modulated by the presence of either folliculin-interacting protein (FNIP)-1 or FNIP2 (show FNIP2 Proteins) and further regulated by ULK1 (show ULK1 Proteins).

  9. Two predominant genes, ephrin type A receptor 6 (EPHA6 (show Epha6 Proteins)) and folliculin (FLCN), with mutations exclusive to African American CRCs, are by genetic and biological criteria highly likely African American CRC (show CALR Proteins) driver genes.

  10. Findings suggest that folliculin deficient renal cell carcinoma (show MOK Proteins) cells are highly sensitive to irradiation due to increased autophagic cell death, unlike other types of renal cell carcinoma (show MOK Proteins).

FLCN Protein Profile

Protein Summary

This gene is located within the Smith-Magenis syndrome region on chromosome 17. Mutations in this gene are associated with Birt-Hogg-Dube syndrome, which is characterized by fibrofolliculomas, renal tumors, lung cysts, and pneumothorax. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

Gene names and symbols associated with Folliculin Proteins (FLCN)

  • folliculin (FLCN)
  • folliculin (flcn)
  • folliculin (Flcn)
  • AU014660 protein
  • B430214A04Rik protein
  • BHD protein
  • FLCL protein
  • flcn protein
  • wu:fe38g11 protein
  • zgc:136982 protein

Protein level used designations for Folliculin Proteins (FLCN)

folliculin , folliculin-like , birt-Hogg-Dube syndrome protein homolog , BHD skin lesion fibrofolliculoma protein , birt-Hogg-Dube syndrome protein

GENE ID SPECIES
454472 Pan troglodytes
698082 Macaca mulatta
496819 Xenopus (Silurana) tropicalis
678628 Danio rerio
100158392 Xenopus laevis
100395467 Callithrix jacchus
100431335 Pongo abelii
100470222 Ailuropoda melanoleuca
216805 Mus musculus
303185 Rattus norvegicus
201163 Homo sapiens
416503 Gallus gallus
479529 Canis lupus familiaris
526652 Bos taurus
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