You are viewing an incomplete version of our website. Please click to reload the website as full version.

Folylpolyglutamate Synthase Proteins (FPGS)

FPGS encodes the folylpolyglutamate synthetase enzyme. Additionally we are shipping FPGS Antibodies (43) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FPGS 2356 Q05932
Rat FPGS FPGS 687266  
FPGS 14287 P48760
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top FPGS Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

FPGS Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Folylpolyglutamate Synthase (FPGS) Interaction Partners

Human Folylpolyglutamate Synthase (FPGS) interaction partners

  1. These results indicate that elevated expressions of the tumor-related genes FPGS/GGH and VEGF are correlated with malignancy of thymic carcinoma and B3 thymoma tumors.

  2. 529 adults (n = 325 European-Americans, 204 Egyptians) on a stable warfarin dose were genotyped for GGCX (show GGCX Proteins) rs12714145 and rs10654848, FPGS rs7856096, and STX1B (show STX1B Proteins) rs4889606.

  3. data suggest that FPGS modulation affects global and promoter CpG DNA methylation (show HELLS Proteins) and expression of several genes involved in important biological pathways

  4. the highest expression of GGH (show GGH Proteins) and EGFR (show EGFR Proteins) was noted in the left-sided colon; the highest expression of DHFR (show DHFR Proteins), FPGS, TOP1 (show TOP1 Proteins) and ERCC1 (show ERCC1 Proteins) was noted in the rectosigmoid, whereas TYMP (show TYMP Proteins) expression was approximately equivalent in the right-sided colon and rectum

  5. FPGS and ABCB1 (show ABCB1 Proteins) genetic variants can influence the outcome in RA patients receiving MTX (show MTX1 Proteins) monotherapy.

  6. Genetic polymorphisms in the FPGS coding region are significantly associated with increased Acute Lymphoblastic Leukemia risk.

  7. study found that genetic polymorphism of FPGS rs10760502A > G is associated with susceptibility to primary retroperitoneal liposasrcoma

  8. antifolate resistant leukemia cells harbor a heterozygous point mutation in exon12 of FPGS which disrupts FPGS activity by abolishing ATP binding, and alters the binding pattern of transcription factors to the genomic region of exon12.

  9. Genome-wide association studies identify 10 novel genetic loci as risk factors for methotrexate response in rheumatoid arthritis patients additionally to polymorphism in DHFR (show DHFR Proteins), FPGS and TYMS (show TYMS Proteins).

  10. mitochondrial FPGS is required because folate polyglutamates are not substrates for transport across the mitochondrial membrane

Mouse (Murine) Folylpolyglutamate Synthase (FPGS) interaction partners

  1. These results suggest that FPGS and GGH (show GGH Proteins) expression levels in tumors are determinants of the efficacy of LV in enhancing the antitumor activity of 5-FU.

FPGS Protein Profile

Protein Summary

This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. While several transcript variants may exist for this gene, the full-length natures of only two have been biologically validated to date. These two variants encode distinct isoforms.

Gene names and symbols associated with FPGS

  • folylpolyglutamate synthase (fpgs)
  • folylpolyglutamate synthase (fpgS)
  • folylpolyglutamate synthase (FPGS)
  • folylpolyglutamate synthase (SCO2614)
  • folylpolyglutamate synthase (fgs)
  • folylpolyglutamate synthase (folC)
  • dihydrofolate synthase (folC)
  • folylpolyglutamate synthase, mitochondrial (CpipJ_CPIJ008043)
  • folylpolyglutamate synthase (Fpgs)
  • folylpolyglutamyl synthetase (Fpgs)
  • AA408187 protein
  • BA4689 protein
  • fpgS protein
  • SCC88.25c protein
  • wu:fk49h03 protein
  • wu:fk51d09 protein
  • zgc:63807 protein

Protein level used designations for FPGS

fk51d09 , folylpolyglutamate synthase, mitochondrial , folylpolyglutamate synthase , folylpoly-gamma-glutamate synthetase , tetrahydrofolate synthase , tetrahydrofolylpolyglutamate synthase , Folylpoly-gamma-glutamate synthetase , Tetrahydrofolate synthase , Tetrahydrofolylpolyglutamate synthase , folylpoly-gammaglutamate synthetase

GENE ID SPECIES
406746 Danio rerio
1211280 Streptomyces avermitilis MA-4680
699587 Macaca mulatta
1098048 Streptomyces coelicolor A3(2)
609176 Canis lupus familiaris
1064577 Tropheryma whipplei TW08/27
1083723 Bacillus anthracis str. Ames
1208787 Coxiella burnetii RSA 493
2798635 Listeria monocytogenes serotype 4b str. F2365
3233504 Ehrlichia ruminantium str. Welgevonden
6040770 Culex quinquefasciatus
2356 Homo sapiens
505809 Bos taurus
687266 Rattus norvegicus
14287 Mus musculus
100689022 Cricetulus griseus
Selected quality suppliers for FPGS Proteins (FPGS)
Did you look for something else?