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FPGS encodes the folylpolyglutamate synthetase enzyme. Additionally we are shipping FPGS Antibodies (39) and many more products for this protein.
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FPGS and ABCB1 (show ABCB1 Proteins) genetic variants can influence the outcome in RA patients receiving MTX (show MTX1 Proteins) monotherapy.
Genetic polymorphisms in the FPGS coding region are significantly associated with increased Acute Lymphoblastic Leukemia risk.
study found that genetic polymorphism of FPGS rs10760502A > G is associated with susceptibility to primary retroperitoneal liposasrcoma
antifolate resistant leukemia cells harbor a heterozygous point mutation in exon12 of FPGS which disrupts FPGS activity by abolishing ATP binding, and alters the binding pattern of transcription factors to the genomic region of exon12.
Genome-wide association studies identify 10 novel genetic loci as risk factors for methotrexate response in rheumatoid arthritis patients additionally to polymorphism in DHFR (show DHFR Proteins), FPGS and TYMS (show TYMS Proteins).
mitochondrial FPGS is required because folate polyglutamates are not substrates for transport across the mitochondrial membrane
Polymorphism of FPGS rs1544105 G>A is associated with response to therapy in acute lymphoblastic leukemia.
An interaction term, between FPGS rs7033913 heterozygotes and GGH (show GGH Proteins) rs11988534 homozygotes for the minor allele, had a p-value <0.0001 and may contribute to methotrexate toxicity in rheumatoid arthritis.
High Folylpoly-glutamate (show GRIN1 Proteins) synthetase expression is associated with response to therapy in non-small-cell lung cancer.
A novel missense mutation 502/490 T>C (L151/101P) in exon 5 of FPGS gene is firstly found in Chinese Han children, and the cytosolic and mitochondrial variants display allelic frequencies of 0.70 % and 0.47 % respectively.
These results suggest that FPGS and GGH (show GGH Proteins) expression levels in tumors are determinants of the efficacy of LV in enhancing the antitumor activity of 5-FU.
This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. While several transcript variants may exist for this gene, the full-length natures of only two have been biologically validated to date. These two variants encode distinct isoforms.
, folylpolyglutamate synthase, mitochondrial
, folylpolyglutamate synthase
, folylpoly-gamma-glutamate synthetase
, tetrahydrofolate synthase
, tetrahydrofolylpolyglutamate synthase
, Folylpoly-gamma-glutamate synthetase
, Tetrahydrofolate synthase
, Tetrahydrofolylpolyglutamate synthase
, folylpoly-gammaglutamate synthetase