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Forkhead Box C1 Proteins (FOXC1)

FOXC1 belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. Additionally we are shipping FOXC1 Antibodies (89) and FOXC1 Kits (31) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FOXC1 2296 Q12948
FOXC1 17300 Q61572
Rat FOXC1 FOXC1 364706  
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Top FOXC1 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Mouse His tag   100 μg Log in to see 11 to 13 Days
$855.80
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$1,030.69
Details

FOXC1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Forkhead Box C1 (FOXC1) Interaction Partners

Human Forkhead Box C1 (FOXC1) interaction partners

  1. Disruptions of enhancers near FOXC1 and GMDS (show GMDS Proteins) may influence brain development.

  2. We report a novel FOXC1 mutation (p. R127L) in a three-generation family with three ARS (show SLURP1 Proteins) and heart defect (show Vcan Proteins) patients.

  3. FOXC1 directly binds Gli2 and potentiates Gli2 DNA-binding activity.

  4. This study shows that hsa (show CD24 Proteins)-miR548-l regulates FOXC1 translation, contributing to better understand the fine regulation of the biological function of this transcription factor.

  5. A meta-analysis of the top SNPs identified three new associated loci in primary open angle glaucoma--TXNRD2 (show TXNRD2 Proteins), ATXN2 (show ATXN2 Proteins), and FOXC1

  6. These findings suggest that miR (show MLXIP Proteins)-4792 functions as a tumor suppressor in NPC (show NPC1 Proteins) development and progression by targeting FOXC1.

  7. Our data indicate that miR (show MLXIP Proteins)-138-5p may play an important role in regulating pancreatic cancer cell growth, possibly through targeting FOXC1

  8. The results support that moderate and variable FOXC1 transactivation changes are associated with moderate goniodysgenesis, dominant glaucoma and remarkable phenotypic variability.

  9. Foxc1 is essential for progenitor cell development and maintenance of bone marrow niches for these cells upregulating CXCL12 (show CXCL12 Proteins) and SCF (show KITLG Proteins) expression and inhibiting of adipogenic processes in cell progenitors. (Review)

  10. In HCC (show FAM126A Proteins) cell lines, IL8 (show IL8 Proteins) activates expression of FOXC1 via the phosphoinositide 3-kinase signaling to AKT (show AKT1 Proteins) and hypoxia-inducible factor 1alpha. FOXC1 expression leads to transactivation of CXCR1 (show CXCR1 Proteins) and CCL2 (show CCL2 Proteins), promoting inflammation and invasivion/metastasis.

Mouse (Murine) Forkhead Box C1 (FOXC1) interaction partners

  1. FOXC1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential.FOXC1 is necessary to establish a multiple-bulge hair follicle architecture.

  2. deletion of Foxc1 and Foxc2 (show FOXC2 Proteins) specifically in Pax3 (show PAX3 Proteins)-positive cells affects cell fate choices in the dermomyotome of somites at forelimb level, promoting the myogenic cell fate at the expense of endothelial cells that migrate to the limb

  3. Foxc1 is an important transcriptional partner of Ihh-Gli2 signalling during endochondral ossification, and that disruption of the Foxc1-Gli2 interaction causes skeletal abnormalities observed in the Axenfeld-Rieger syndrome.

  4. In self-renewing stem cells (SCs), Foxc1 activates Nfatc1 and bone morphogenetic protein (BMP) signaling, two key mechanisms that govern quiescence. These findings reveal a dynamic, cell-intrinsic mechanism used by hair follicle SCs to reinforce quiescence upon self-renewal and suggest a unique ability of SCs to maintain cell identity.

  5. These observations reveal an essential role for Foxc1 in the early stage of vascular formation in the telencephalon.

  6. loss of Foxc1 non-autonomously induces a rapid and devastating decrease in embryonic cerebellar ventricular zone radial glial proliferation and concurrent increase in cerebellar neuronal differentiation

  7. A loss of Foxc1 function affects skull bone formation of the apical region.

  8. Together our data demonstrates that Foxc1 - Fgf8 (show FGF8 Proteins) signaling regulates mammalian jaw patterning and provides a mechanistic basis for the pathogenesis of syngnathia.

  9. identification of Foxc1 as a specific transcriptional regulator essential for development and maintenance of the mesenchymal niches for haematopoietic stem and progenitor cells

  10. FOXC1 is unnecessary for mammary morphogenesis; role in basal-like breast cancer likely involves processes that are unrelated to cell lineage specification.

FOXC1 Protein Profile

Protein Summary

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined\; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly.

Gene names and symbols associated with Forkhead Box C1 Proteins (FOXC1)

  • forkhead box C1 (foxc1)
  • forkhead box C1 (FOXC1)
  • Forkhead box protein C1 (foxc1)
  • forkhead box C1 (Foxc1)
  • forkhead box C1 (foxc1-b)
  • ARA protein
  • CFKH-1 protein
  • ch protein
  • fkh-1 protein
  • Fkh1 protein
  • FKHL7 protein
  • foxc1 protein
  • FREAC-3 protein
  • FREAC3 protein
  • frkhda protein
  • IGDA protein
  • IHG1 protein
  • IRID1 protein
  • Mf1 protein
  • Mf4 protein
  • RIEG3 protein
  • xfd-11 protein

Protein level used designations for Forkhead Box C1 Proteins (FOXC1)

forkhead box protein C1 , forkhead box C1 , Forkhead box protein C1 , forkhead, drosophila, homolog-like 7 , forkhead-related activator 3 , forkhead-related protein FKHL7 , forkhead-related transcription factor 3 , forkhead/winged helix-like transcription factor 7 , myeloid factor-delta , FREAC-3 , MF-1 , congenital hydrocephalus , mesoderm/mesenchyme forkhead 1 , transcription factor FKH-1 , forkhead box protein C1-B , winged helix protein CWH-6 , winged-helix transcription factor

GENE ID SPECIES
493250 Xenopus (Silurana) tropicalis
722918 Macaca mulatta
750577 Pan troglodytes
100028901 Monodelphis domestica
100195202 Salmo salar
2296 Homo sapiens
17300 Mus musculus
734912 Xenopus laevis
364706 Rattus norvegicus
395856 Gallus gallus
101102186 Ovis aries
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