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Transcriptional activator (By similarity). Additionally we are shipping Forkhead Box J2 Antibodies (39) and many more products for this protein.
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FOXJ2 expression was down-regulated by transforming growth factor-beta1 (TGF-beta1 (show TGFB1 Proteins)) treated, and overexpression of FOXJ2 inhibited TGF-beta1 (show TGFB1 Proteins)-induced epithelial-mesenchymal transition.
Data shows that FOXJ2 is downregulated in extrahepatic cholangiocarcinoma tissues and associates with disease progression. Its overexpression inhibits cell proliferation, migration and invasion in vitro indicating a role as tumor suppressor gene.
FoxJ2 suppressed cell migration and invasion in glioma
Our analysis showed significant downregulation of miRNAs, let-7b and miR (show MLXIP Proteins)-197, out of which miR (show MLXIP Proteins)-197 was predicted to target FOXJ2.
MicroRNA-34a targets FOXJ2 to modulate differentiation of endothelial progenitor cells in response to shear stress.
Study demonstrates that FOXJ2 can inhibit the metastasis of human breast cancer by regulating the EMT (show ITK Proteins) key markers E-cadherin (show CDH1 Proteins) and vimentin (show VIM Proteins).
Foxj2 seems to be required for the production of interferon-alpha (show IFNA Proteins) in Plasmacytoid dendritic cells, because Foxj2-specific siRNA decreased interferon-alpha (show IFNA Proteins) levels for both MRL/Mp-Fas-lpr (show FAS Proteins), as well as its parent strain, MRL mice.
Biological effects of Foxj2 overexpression during development are reported.
Transcriptional activator (By similarity).
forkhead box J2
, forkhead box protein J2
, forkhead box protein J2-like
, FOXJ2 forkhead factor
, fork head homologous X
, forkhead box J2 a