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The protein encoded by FOXK2 contains a fork head DNA binding domain. Additionally we are shipping Forkhead Box K2 Antibodies (69) and many more products for this protein.
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SOX9 (show SOX9 Proteins) transcriptionally activated FOXK2 was involved in the pathogenesis of colorectal cancer.FOXK2 is highly expressed in colorectal cancer tissues.
Results show that Foxk2 expression was downregulated in lung adenocarcinoma tissues and non-small cell lung cancer cell (NSCLC) lines. Its overexpression suppresses epithelial-mesenchymal transition in NSCLC cells and inhibits cell migration and invasion. Also, the expression of Foxk2 seems to be regulated by miR (show MLXIP Proteins)-1271.
FOXO3 (show FOXO3 Proteins)-dependent gene regulation is generally mediated not through uniquely bound regions but through regions occupied by both FOXK2 and FOXO3 (show FOXO3 Proteins) where both factors play a regulatory role.
FOXK2 might act as a negative regulator of ERalpha (show ESR1 Proteins), and its association with both ERalpha (show ESR1 Proteins) and BRCA1/BARD1 (show BARD1 Proteins) could lead to the down-regulation of ERalpha (show ESR1 Proteins) transcriptional activity, effectively regulating the function of ERalpha (show ESR1 Proteins).
FOXK1 and FOXK2 positively regulate Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling by translocating dishevelled (show DVL2 Proteins) proteins into the nucleus.
BAP1 (show RNF2 Proteins) deficiency causes increased expression of FoxK2 target genes in a Ring1B (show RNF2 Proteins)-Bmi1 (show BMI1 Proteins)-dependent manner
FOXK2 can promote transcriptional activation and is required for the efficient recruitment of AP-1 (show FOSB Proteins) components to chromatin.
Data show that FOXK2 is subject to control by cell cycle-regulated hyperphosphorylation occurring in CDK (show CDK4 Proteins)).cyclin (show PCNA Proteins)-dependent manner with CDK1 (show CDK1 Proteins).cyclin B as the major kinase complex.
FOXK2 is a G/T-mismatch DNA-binding protein (show UBE2V1 Proteins) and a deaminated DNA-binding protein (show UBE2V1 Proteins)
FoxK2 is required for proliferation and survival.
Foxk1 and Foxk2 are identified as transcriptional repressors of autophagy in muscle cells and fibroblasts.
The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements.
, forkhead box protein K2
, forkhead box K2
, cellular transcription factor ILF-1
, interleukin enhancer binding factor 1
, interleukin enhancer-binding factor 1