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The protein encoded by FOXN1 is part of the forkhead family or 'winged-helix' transcription factors that are important in developmental processes, immune system regulation, metabolism, cancer and aging. Additionally we are shipping FOXN1 Antibodies (75) and many more products for this protein.
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the foxn1-mcm2 (show MCM2 Proteins) axis plays a central role in the genetic regulatory network controlling thymus development in zebrafish
zebrafish orthologue (whnb) of the mouse nude gene is expressed in the epithelial compartment of the embryonic thymic rudiment
an evolutionarily conserved role of BMP signaling in the maintenance of Foxn1 expression.
Whole-exome sequencing in a South American coh (show RARB Proteins)ort links ALDH1A3, FOXN1 and RARB/retinoic acid regulation pathways to autism s (show ALDH1A3 Proteins)pectrum disorders.
Identification of a unique mutation in FOXN1 that led to severe combined immunodeficiency (show PRKDC Proteins) in a female infant is reported.
These results show that miR (show MLXIP Proteins)-18b and miR (show MLXIP Proteins)-518b are upstream controllers of FOXN1-directed epithelial lineage development.
The retinoid-related orphan receptor (show NR1D2 Proteins) RORalpha promotes keratinocyte differentiation via FOXN1.
This is the first description of leucoderma occurring in a patient with Foxn1 deficiency, as well as the first report of this pigment abnormality following thymus transplantation.
results show that FOXN1 is crucial for in utero T cell development, but not for B and NK cell differentiation
role of FOXN1 in immunological disorders characterized by abnormal T-cell development or abnormal T-cell regulatory homeostasis [Review]
study uncovered a positive regulatory loop between FGFR3 (show FGFR3 Proteins) and FOXN1 that underlies a benign versus malignant skin tumor phenotype
Mutation of the FOXN1 gene is associated with congenital severe combined immunodeficiency (show PRKDC Proteins) associated with alopecia
These results establish a role for FOXN1 in initiation of terminal differentiation and implicate Akt (show AKT1 Proteins) in subsequent events.
sphingolipids and fatty acids associated with a decrease in glycerolipids suggest that the lipidome in mice skin is regulated by the Foxn1 (show FOXN2 Proteins) gene
Foxn1 (show FOXN2 Proteins) transcription factor regulates wound healing of skin through promoting epithelial-mesenchymal transition.
early differentiation and maturation of cortical and medullary thymic epithelial cells coincides with precise sub-lineage-specific regulation of Foxn1 (show FOXN2 Proteins) expression levels.
Chromatin immunoprecipitation assay using RarB (show RARB Proteins) as the immunoprecipitation target suggests retinoic acid regulation of Aldh1a3 (show ALDH1A3 Proteins) and Foxn1 (show FOXN2 Proteins) in mice.
The maturation and distribution of thymic epithelial cells in the Foxn1 (show FOXN2 Proteins)(-/-) thymic rudiment and the thymopoiesis of this newly developed rudiment, were examined.
Expression of FoxN1 (show FOXN2 Proteins) in early life adversely influence immature epithelial cells T and B cell, and skin epithelial development.
this study presents the characterization of the adult thymic epithelial stem cells and demonstrates the dispensability of FoxN1 (show FOXN2 Proteins) function for their stemness.
Enforced Foxn1 (show FOXN2 Proteins) expression is sufficient to reprogramme fibroblasts into functional thymic epithelial cells.
TAp63 levels are positively correlated with TEC (show NR4A3 Proteins) senescence but inversely correlated with expression of FoxN1 (show FOXN2 Proteins) and FoxN1 (show FOXN2 Proteins)-regulated thymic epithelial cell differentiation.
Upregulation of a single transcription factor can substantially reverse age-related thymic involution, identifying FOXN1 (show FOXN2 Proteins) as a specific target for improving thymus function.
The protein encoded by this gene is part of the forkhead family or 'winged-helix' transcription factors that are important in developmental processes, immune system regulation, metabolism, cancer and aging. This gene family has over 100 members, subdivided into classes (A-Q) based on phylogeny. The encoded protein is proposed to regulate development of the thymus and differentiation of keratinocytes. Mutations in this gene cause severe primary T-cell immunodeficiency and congenital alopecia. In mouse mutations of this gene underlie the phenotype of the nude mouse, which has been widely used as a model system in oncology, immunology, dermatology, and transplantation studies. In humans mutations in this gene have been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
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, hepatocyte nuclear factor 3 forkhead homolog 11