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Forkhead Box N1 Proteins (FOXN1)

The protein encoded by FOXN1 is part of the forkhead family or 'winged-helix' transcription factors that are important in developmental processes, immune system regulation, metabolism, cancer and aging. Additionally we are shipping FOXN1 Antibodies (79) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FOXN1 8456 O15353
FOXN1 15218 Q61575
Rat FOXN1 FOXN1 287469  
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Top FOXN1 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details

FOXN1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Forkhead Box N1 (FOXN1) Interaction Partners

Zebrafish Forkhead Box N1 (FOXN1) interaction partners

  1. the foxn1-mcm2 (show MCM2 Proteins) axis plays a central role in the genetic regulatory network controlling thymus development in zebrafish

  2. zebrafish orthologue (whnb) of the mouse nude gene is expressed in the epithelial compartment of the embryonic thymic rudiment

  3. an evolutionarily conserved role of BMP signaling in the maintenance of Foxn1 expression.

Human Forkhead Box N1 (FOXN1) interaction partners

  1. Whole-exome sequencing in a South American coh (show RARB Proteins)ort links ALDH1A3, FOXN1 and RARB/retinoic acid regulation pathways to autism s (show ALDH1A3 Proteins)pectrum disorders.

  2. Identification of a unique mutation in FOXN1 that led to severe combined immunodeficiency (show PRKDC Proteins) in a female infant is reported.

  3. These results show that miR (show MLXIP Proteins)-18b and miR (show MLXIP Proteins)-518b are upstream controllers of FOXN1-directed epithelial lineage development.

  4. The retinoid-related orphan receptor (show NR1D2 Proteins) RORalpha promotes keratinocyte differentiation via FOXN1.

  5. This is the first description of leucoderma occurring in a patient with Foxn1 deficiency, as well as the first report of this pigment abnormality following thymus transplantation.

  6. results show that FOXN1 is crucial for in utero T cell development, but not for B and NK cell differentiation

  7. role of FOXN1 in immunological disorders characterized by abnormal T-cell development or abnormal T-cell regulatory homeostasis [Review]

  8. study uncovered a positive regulatory loop between FGFR3 (show FGFR3 Proteins) and FOXN1 that underlies a benign versus malignant skin tumor phenotype

  9. Mutation of the FOXN1 gene is associated with congenital severe combined immunodeficiency (show PRKDC Proteins) associated with alopecia

  10. These results establish a role for FOXN1 in initiation of terminal differentiation and implicate Akt (show AKT1 Proteins) in subsequent events.

Mouse (Murine) Forkhead Box N1 (FOXN1) interaction partners

  1. sphingolipids and fatty acids associated with a decrease in glycerolipids suggest that the lipidome in mice skin is regulated by the Foxn1 (show FOXN2 Proteins) gene

  2. Foxn1 (show FOXN2 Proteins) transcription factor regulates wound healing of skin through promoting epithelial-mesenchymal transition.

  3. early differentiation and maturation of cortical and medullary thymic epithelial cells coincides with precise sub-lineage-specific regulation of Foxn1 (show FOXN2 Proteins) expression levels.

  4. Chromatin immunoprecipitation assay using RarB (show RARB Proteins) as the immunoprecipitation target suggests retinoic acid regulation of Aldh1a3 (show ALDH1A3 Proteins) and Foxn1 (show FOXN2 Proteins) in mice.

  5. The maturation and distribution of thymic epithelial cells in the Foxn1 (show FOXN2 Proteins)(-/-) thymic rudiment and the thymopoiesis of this newly developed rudiment, were examined.

  6. Expression of FoxN1 (show FOXN2 Proteins) in early life adversely influence immature epithelial cells T and B cell, and skin epithelial development.

  7. this study presents the characterization of the adult thymic epithelial stem cells and demonstrates the dispensability of FoxN1 (show FOXN2 Proteins) function for their stemness.

  8. Enforced Foxn1 (show FOXN2 Proteins) expression is sufficient to reprogramme fibroblasts into functional thymic epithelial cells.

  9. TAp63 levels are positively correlated with TEC (show NR4A3 Proteins) senescence but inversely correlated with expression of FoxN1 (show FOXN2 Proteins) and FoxN1 (show FOXN2 Proteins)-regulated thymic epithelial cell differentiation.

  10. Upregulation of a single transcription factor can substantially reverse age-related thymic involution, identifying FOXN1 (show FOXN2 Proteins) as a specific target for improving thymus function.

FOXN1 Protein Profile

Protein Summary

The protein encoded by this gene is part of the forkhead family or 'winged-helix' transcription factors that are important in developmental processes, immune system regulation, metabolism, cancer and aging. This gene family has over 100 members, subdivided into classes (A-Q) based on phylogeny. The encoded protein is proposed to regulate development of the thymus and differentiation of keratinocytes. Mutations in this gene cause severe primary T-cell immunodeficiency and congenital alopecia. In mouse mutations of this gene underlie the phenotype of the nude mouse, which has been widely used as a model system in oncology, immunology, dermatology, and transplantation studies. In humans mutations in this gene have been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

Gene names and symbols associated with Forkhead Box N1 Proteins (FOXN1)

  • forkhead box N1 (FOXN1)
  • forkhead box N1 (foxn1)
  • forkhead box N1 (foxN1)
  • transcription factor Forkhead box protein N1 (foxn1)
  • forkhead box N1 (Foxn1)
  • D11Bhm185e protein
  • Fkh19 protein
  • FKHL20 protein
  • foxN protein
  • foxn1 protein
  • HFH-11 protein
  • Hfh11 protein
  • nu protein
  • nude protein
  • Rnu protein
  • RONU protein
  • Whn protein
  • whnb protein

Protein level used designations for Forkhead Box N1 Proteins (FOXN1)

forkhead box protein N1 , forkhead box N1 , forkhead box N protein , forkhead box protein N1-like , transcription factor Forkhead box protein N1 , Rowett nude , winged helix nude , winged-helix nude , winged-helix transcription factor nude , HNF-3/forkhead homolog 11 , hepatocyte nuclear factor 3 forkhead homolog 11

GENE ID SPECIES
417570 Gallus gallus
100059109 Equus caballus
266748 Danio rerio
468381 Pan troglodytes
708926 Macaca mulatta
100024620 Monodelphis domestica
100303472 Saccoglossus kowalevskii
100410086 Callithrix jacchus
100467385 Ailuropoda melanoleuca
100601006 Nomascus leucogenys
100125524 Oryzias latipes
8456 Homo sapiens
491168 Canis lupus familiaris
516724 Bos taurus
15218 Mus musculus
287469 Rattus norvegicus
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