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FOXP1 belongs to subfamily P of the forkhead box (FOX) transcription factor family. Additionally we are shipping FOXP1 Antibodies (171) and FOXP1 Kits (19) and many more products for this protein.
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Prominent foxp1 expression is detected in many regions of the developing central nervous system, especially in midbrain-hindbrain boundary, hindbrain, and spinal cord.
FOXP1 has protein-protein interaction with NFAT1 (show NFAT1 Proteins) on DNA and enhances breast cancer cell migration by repressing NFAT1 (show NFAT1 Proteins) transcriptional activity.
FOXP1 functions as an oncogene (show RAB1A Proteins) in promoting cancer stem cell-like characteristics in ovarian cancer cells.
The findings highlight that de novo FOXP1 variants are a cause of sporadic intellectual disability and emphasize the importance of this transcription factor in neurodevelopment.
we provide supportive evidence that genetic variants at FOXP1, BARX1 (show BARX1 Proteins), and FOXF1 (show FOXF1 Proteins) confer risk for the development of EAC (show CYLD Proteins).
Cell-line derived FOXP1 target genes that were highly correlated with FOXP1 expression in primary DLBCL accurately segregated the corresponding clinical subtypes of a large cohort of primary DLBCL isolates
S1PR2 (show S1PR2 Proteins) is repressed by FOXP1 in activated B-cell and germinal center B-cell DLBCL cell lines with aberrantly high FOXP1 levels; S1PR2 (show S1PR2 Proteins) expression is further inversely correlated with FOXP1 expression in 3 DLBCL patient cohorts.
FOXP1 represents a novel regulator of genes targeted by the class II MHC (show HLAE Proteins) transactivator CIITA (show CIITA Proteins) and CD74 (show CD74 Proteins).
FOXP1 - novel candidate genes validated in a large case-control sample of schizophrenia.
Studied the expression of FOXP1 in colorectal cancer and its potential associations with outcome in colorectal cancer.
Authors identified forkhead box protein P1 (FOXP1) as a direct target of miR (show MLXIP Proteins)-504 using microarray analysis and a luciferase assay.
En1 (show EN1 Proteins)-null cells also fail to express the transcription factor FoxP1, suggesting that FoxP1 lies downstream of En1 (show EN1 Proteins).
The response of CPLX1 and Foxp1 levels to SNCA deficiency supports the notion that these factors are regulated by altered physiological function of alpha-synuclein.
These results identify a previously unrecognized role for FOXP1 in the transcriptional control of hepatic glucose homeostasis.
results demonstrate critical roles of Foxp1 in the radial migration and morphogenesis of cortical neurons during development.
a novel role for Foxp1 in controlling HFSC proliferation with cellular dynamic location in response to oxidative stress during hair cycling
Collectively, these findings reveal an important role for the FOXP1, 2, and 4 proteins in governing postnatal alpha cell expansion and function.
Foxp1 mediates programming of limb-innervating motor neurons from mouse and human embryonic stem cells.
Foxp1/2/4 may regulate Runx2 (show RUNX2 Proteins) during endochondral ossification.
The results unveil a fundamental mechanism of T cell unresponsiveness different from anergy or exhaustion, driven by TGF-beta (show TGFB1 Proteins) signaling on tumor-associated lymphocytes undergoing Foxp1-dependent transcriptional regulation.
Foxp1 also dampened expression of the costimulatory molecule (show CD276 Proteins) ICOS (show ICOS Proteins) and its downstream signaling at early stages of T cell activation
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms.
forkhead box P1
, forkhead box protein P1-B
, forkhead box protein P1-like
, forkhead box protein P1
, fork head-related protein like B
, glutamine-rich factor 1
, forkhead-related transcription factor 1