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FOXP2 encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. Additionally we are shipping FOXP2 Proteins (6) and many more products for this protein.
Showing 10 out of 126 products:
Cow (Bovine) Polyclonal FOXP2 Primary Antibody for IHC (p), WB - ABIN374127
Arellano, Guadiana, Breunig, Rakic, Sarkisian: Development and distribution of neuronal cilia in mouse neocortex. in The Journal of comparative neurology 2012
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Human Polyclonal FOXP2 Primary Antibody for ICC, IHC (fro) - ABIN188687
Lai, Fisher, Hurst, Vargha-Khadem, Monaco: A forkhead-domain gene is mutated in a severe speech and language disorder. in Nature 2001
Show all 5 references for ABIN188687
Human Polyclonal FOXP2 Primary Antibody for IF, WB - ABIN651939
Margolis, Abraham, Gatchell, Li, Kidwai, Breschel, Stine, Callahan, McInnis, Ross: cDNAs with long CAG trinucleotide repeats from human brain. in Human genetics 1997
Show all 3 references for ABIN651939
Human Polyclonal FOXP2 Primary Antibody for IHC, ELISA - ABIN263146
Fujita, Sugihara: FoxP2 expression in the cerebellum and inferior olive: development of the transverse stripe-shaped expression pattern in the mouse cerebellar cortex. in The Journal of comparative neurology 2011
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Human Polyclonal FOXP2 Primary Antibody for WB - ABIN871710
Bruce, Margolis: FOXP2: novel exons, splice variants, and CAG repeat length stability. in Human genetics 2002
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Human Monoclonal FOXP2 Primary Antibody for ELISA, WB - ABIN969155
Konopka, Bomar, Winden, Coppola, Jonsson, Gao, Peng, Preuss, Wohlschlegel, Geschwind: Human-specific transcriptional regulation of CNS development genes by FOXP2. in Nature 2009
Show all 2 references for ABIN969155
Human Polyclonal FOXP2 Primary Antibody for IHC, ELISA - ABIN334400
Fujita, Morita, Furuichi, Sugihara: Clustered fine compartmentalization of the mouse embryonic cerebellar cortex and its rearrangement into the postnatal striped configuration. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
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Dog (Canine) Polyclonal FOXP2 Primary Antibody for IHC, WB - ABIN2778104
Sanjuán, Tolosa, González, Aguilar, Pérez-Tur, Nájera, Moltó, de Frutos: Association between FOXP2 polymorphisms and schizophrenia with auditory hallucinations. in Psychiatric genetics 2006
FOXP2 can be modified with all three human SUMO proteins and that PIAS1 (show PIAS1 Antibodies) promotes this process.
FOXP2 is a substrate for SUMOylation and SUMOylation of FOXP2 plays a functional role in regulating its transcriptional activity.
CNTNAP2 (show CNTNAP2 Antibodies) is transcriptionally regulated by FOXP2.
Data suggest FOXP2 binds DNA as monomer; FOXP2 hinge loop domain mutants exhibit either decreased formation of homodimer (A539P) or decreased dissociation of homodimer (F541C); naturally occurring reverse mutation (P539A) increases DNA binding affinity.
Genetic variants in FOXP2 may be significant for rare forms of language impairment, they do not contribute appreciably to individual variation in the normal range as found in the general population.
Our results suggested that FOXP2 expression was downregulated in Hepatocellular carcinoma tumor tissues, and reduced FOXP2 expression was associated with poor overall survival
TBR1 (show TBR1 Antibodies) homodimerizes; it interacts with FOXP2, a transcription factor implicated in speech/language disorders, and this interaction is disrupted by pathogenic mutations affecting either protein
FOXF2 (show FOXF2 Antibodies) deficiency enhances metastatic ability of BLBC cells by activating the EMT (show ITK Antibodies) program through upregulating the transcription of TWIST1 (show TWIST1 Antibodies).
Random monoallelic expression impacts the haploinsufficiency phenotypes observed for FOXP2 mutations.
pH had a direct effect on FOXP2 binding to DNA affinity.
we demonstrated for the first time that Foxp1 (show FOXP1 Antibodies) and Foxp2 are expressed during craniofacial development. Our data suggest that the Foxp genes may regulate development of the aboral and posterior regions of the jaw.
Combined loss of all three Foxp1 (show FOXP1 Antibodies)/2/4 family members in the developing anterior foregut endoderm leads to a loss of lung endoderm lineage commitment and subsequent development. Foxp1 (show FOXP1 Antibodies)/2/4 deficient lungs express high levels of transcriptional regulators not normally expressed in developing lung. Ectopic expression of these transcriptional regulators is accompanied by decreased expression of lung restricted transcription.
We show that Foxp1 (show FOXP1 Antibodies) and the androgen receptor (show AR Antibodies) are co-expressed in striatal medium spiny neurons and that brain-specific (show CALY Antibodies) androgen receptor (show AR Antibodies) KO (ArNesCre) mice exhibit reduced Foxp1 (show FOXP1 Antibodies) expression in the striatum at E17.5 and P7.5 and an increased Foxp2 level in the cortex at P7.5. Thus, androgens may contribute to sex-specific differences in Foxp1 (show FOXP1 Antibodies) and Foxp2 expression and ultrasonic vocalizations
The Foxp2 gene is critical for normal vocal behavior in juvenile and adult mice.
This study demonstrated that after middle cerebral artery occlusion mice demonstrate profoundly impaired socially evoked USVs and suppression of the language-associated transcription factor, Forkhead box (show FOXO Antibodies) protein 2 (Foxp2).
mice with Foxp2 mutations displayed quantitative differences in ultrasonic vocalizations as compared to wild-types
Collectively, these findings reveal an important role for the FOXP1 (show FOXP1 Antibodies), 2, and 4 proteins in governing postnatal alpha cell expansion and function.
Foxp2 was elevated early after stroke (at 6h), but significantly decreased 24h after injury in both the nucleus and the cytoplasm; neuronal Foxp2 expression increased in stroke mice compared to sham animals 4 weeks after injury
arkypallidal GPe neurons originate from lateral/caudal (show CAD Antibodies) ganglionic eminences, express the transcription factor FoxP2, fire at low rates during rest, and encode movements with robust increases in firing.
Foxp1 (show FOXP1 Antibodies)/2/4 may regulate Runx2 (show RUNX2 Antibodies) during endochondral ossification.
Our findings suggest that foxP2 is not necessary for axon pathfinding during development.
foxP2 likely has a more general conserved role in nervous system development; molecular cloning
The developing optic tectum becomes the major area of FoxP2 expression. In the adult brain, the highest concentrations of the FoxP2 transcript can be observed in the optic tectum.
Domain-specific regulation of foxP2 CNS expression by lef1 (show LEF1 Antibodies).
This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.
forkhead box protein P2
, transcription factor FoxP2
, forkhead box P2
, forkhead box P protein
, forkhead box P2 (predicted), 5 prime
, forkhead box P2 (predicted), 3 prime
, CAG repeat protein 44
, forkhead/winged-helix transcription factor
, trinucleotide repeat containing 10
, trinucleotide repeat-containing gene 10 protein
, forkhead box transcription factor