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Proteins that contain formin (FMN1\; MIM 136535) homology (FH) domains, such as FHOD3, play a role in regulation of the actin cytoskeleton (Kanaya et al., 2005 [PubMed 15966898]).[supplied by OMIM, Apr 2010].. Additionally we are shipping and many more products for this protein.
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Suggest alpha5beta1/Arp2/Arp3/FHOD3 pathway reprograms the actin cytoskeleton to promote invasive migration and local invasion in vivo.
DCM-associated FHOD3 variant may cause DCM by interfering with actin filament assembly.
C-terminal phosphorylation by ROC (show CSNK2A1 Antibodies)K1 is sufficient for FHOD3 activation as evidenced by an increase in F-actin in HeLa cells.
Single nucleotide polymorphism in FHOD3 gene is associated with acute lymphoblastic leukemia.
actin dynamics regulated by Fhod3 are critical for sarcomere organization in striated (show NSDHL Antibodies) muscle cells.
during embryonic cardiogenesis, Fhod3 functions as the essential reorganizer of actin filaments at the central region of maturating sarcomeres via the actin-binding activity of the FH2 domain
Analysis of casein kinase 2 alpha (show CSNK2A1 Antibodies) knockout mice showed that phosphorylation by casein kinase 2 is also required for proper targeting of muscle Fhod3 to the myofibrils in embryonic cardiomyocytes in situ.
embryonic heart of mice specifically expresses the Fhod3 mRNA isoform harboring the three alternative exons
Proteins that contain formin (FMN1\; MIM 136535) homology (FH) domains, such as FHOD3, play a role in regulation of the actin cytoskeleton (Kanaya et al., 2005
FH1/FH2 domain-containing protein 3
, formin homology 2 domain containing 3
, formin homolog overexpressed in spleen 2
, formin-family protein FHOS2
, formin homology 2 domain containing 3-like