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FMNL2 encodes a formin-related protein. Additionally we are shipping FMNL2 Proteins (4) and FMNL2 Kits (2) and many more products for this protein.
Showing 10 out of 22 products:
Human Monoclonal FMNL2 Primary Antibody for ELISA, WB - ABIN566725
Zhu, Liang, Ding: Overexpression of FMNL2 is closely related to metastasis of colorectal cancer. in International journal of colorectal disease 2008
Show all 5 references for ABIN566725
Human Polyclonal FMNL2 Primary Antibody for WB - ABIN2783099
Colland, Jacq, Trouplin, Mougin, Groizeleau, Hamburger, Meil, Wojcik, Legrain, Gauthier: Functional proteomics mapping of a human signaling pathway. in Genome research 2004
miR (show MLXIP Antibodies)-206 functioned as a tumor suppressor in the progression of colorectal cancer(CRC (show CALR Antibodies)) by targeting FMNL2 and c-MET. Restoration of miR (show MLXIP Antibodies)-206 expression may represent a promising therapeutic approach for targeting malignant CRC (show CALR Antibodies).
Capping protein and FMNL2 functionally coregulate filament barbed-end assembly.
The two interacting FMNL-Cdc42 heterodimers expose six membrane interaction motifs on a convex protein surface, the assembly of which may facilitate actin filament elongation at the leading edge of lamellipodia and filopodia.
FMNL2, acting as upstream of RhoA by interacting with LARG, can promote actin assembly and colorectal carcinoma cell invasion through a Rho/ROCK-dependent mechanism.
These data establish a role for FMNL2 in the regulation of beta1-integrin and provide a mechanistic understanding of the function of FMNL2 in cancer invasiveness.
MiR-34a was down-regulated in colorectal cancer cells and inversely correlated with FMNL2 and E2F5 expressions. Our study suggests that miR-34a is an important tumor suppressor of CRC progression by targeting FMNL2 and E2F5.
Rac1-induced actin assembly and subsequent AJ formation critically depends on FMNL2.
miR (show MLXIP Antibodies)-137, induced by its upstream transcription factor HMGA1 (show HMGA1 Antibodies), can suppress colorectal cancer cell invasion and metastasis by targeting FMNL2.
Protein N-myristoylation plays critical roles in the cellular morphological changes induced by FMNL2 and FMNL3 (show FMNL3 Antibodies).
FMNL2 is a novel elongation factor of actin filaments that constitutes the first Cdc42 effector promoting cell migration and actin polymerization at the tips of lamellipodia.
FMNL1 (show FMNL1 Antibodies) and FMNL2 are required non-redundantly in the repair of damaged myofibrils.
mDia1-FH2 has an effect on the conformation of actin filaments
This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. Alternatively spliced transcript variants encoding different isoforms have been described but their full-length nature has yet to be determined.
, formin homology 2 domain containing 2
, formin homology 2 domain-containing protein 2
, formin-like protein 2
, formin-like domain containing protein MAN
, protein Man