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Four and A Half LIM Domains 1 Proteins (FHL1)

FHL1 encodes a member of the four-and-a-half-LIM-only protein family. Additionally we are shipping Four and A Half LIM Domains 1 Antibodies (94) and Four and A Half LIM Domains 1 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FHL1 2273 Q13642
FHL1 14199 P97447
FHL1 25177 Q9WUH4
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Top Four and A Half LIM Domains 1 Proteins at antibodies-online.com

Showing 5 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,731.67
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

FHL1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Four and A Half LIM Domains 1 (FHL1) Interaction Partners

Human Four and A Half LIM Domains 1 (FHL1) interaction partners

  1. Knockdown of FHL1 with FHL1 small interfering RNA (siRNA) promoted tumor growth and Cyclin D and cyclin E (show CCNE1 Proteins) were markedly elevated at both the protein and mRNA level.

  2. results indicate that anti-FHL1 autoantibodies in peripheral blood have promising potential as a biomarker to identify a subset of severe IIM.

  3. In healthy individuals, FHL1A is the predominant splice variant and is mainly found in skeletal and cardiac muscle. In two individuals with an Emery-Dreifuss plus phenotype with pulmonary artery hypoplasia and facial dysmorphology, there was demonstrated loss of isoform A and B, and an almost 200-fold overexpression of isoform C.

  4. FRG1 (show FRG1 Proteins) mice overexpressing FHL1 showed an improvement in the dystrophic phenotype

  5. FHL1 shRNA could significantly accelerate tumor cell growth via inhibiting the expression of FHL1

  6. Our results suggest that miR (show MLXIP Proteins)-410 may function as an oncomiR and are consistent with its key function in regulating FHL1 in certain digestive system cancers.

  7. These data suggested that up-regulated FHL1 in smooth muscle in HSCR (show EDNRB Proteins) might be associated with intestinal wall remodeling in HSCR (show EDNRB Proteins) and might be one of the risk factors for gastrointestinal motor dysfunction

  8. This is the first study to show that FHL1 mutations identified in several clinically distinct myopathies lead to similar protein aggregation and impair myotube formation.

  9. The study has revealed that FHL1C overexpression induces Jurkat cell apoptosis.

  10. FHL-1 is the predominant complement regulator in Bruch's membrane having direct implications for age-related macular degeneration.

Mouse (Murine) Four and A Half LIM Domains 1 (FHL1) interaction partners

  1. KyoT2 downregulates airway remodeling and resistance in asthmatic mice through a Hes1-dependent mechanism.

  2. Results found that osteogenesis increases with the overexpression of Fhl1 and decreases with reduced Fhl1 expression and suggest that Fhl1 mediates interacting estrogen and Wnt (show WNT2 Proteins) signaling during osteogenesis.

  3. Findings indicate that loss of function is responsible for the myopathy in the Fhl1 W122S knock-in mice.

  4. The CSL (show SMPX Proteins)-KyoT2 corepressor complex is a negative regulator of Notch (show NOTCH1 Proteins) signaling.

  5. Data show that loss of FHL1 function leads to myopathy in vivo and suggest that loss of function of FHL1 may be one of the mechanisms underlying muscle dystrophy in patients with FHL1 mutations.

  6. Fhl1 transcriptional changes provide salutary effects on stressed myocytes in cardiomyopathy.

  7. Data suggest Fhl1 (four-and-a-half LIM domains protein 1) and FHL2 (four-and-a-half LIM domains protein 2 (show FHL2 Proteins)) bind to and regulate activity of Prkd1 (protein kinase D (show PRKD1 Proteins) 1) in cardiac/ventricular myocytes; knockdown of Fhl1 down-regulates Prkd1 (show PRKD1 Proteins) activation.

  8. A novel mechanism involving four-and-a-half LIM domain protein (show PDLIM7 Proteins)-1 and extracellular signal-regulated kinase-2 (show MAPK1 Proteins) regulates titin (show TTN Proteins) phosphorylation and mechanics.

  9. Wnt (show WNT2 Proteins) signaling induces muscle cell differentiation, at least partly, through Fhl1 activation.

  10. FHL1 is a novel regulator of myosin-binding (show PPP1R12A Proteins) protein C (show PROC Proteins) activity that may have a role in sarcomere assembly

Pig (Porcine) Four and A Half LIM Domains 1 (FHL1) interaction partners

  1. The LIM domain protein (show PDLIM7 Proteins) FHL1C interacts with tight junction protein ZO-1 (show TJP1 Proteins) contributing to the epithelial-mesenchymal transition of a breast adenocarcinoma cell line.

Four and A Half LIM Domains 1 (FHL1) Protein Profile

Protein Summary

This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode and these proteins are involved in many cellular processes. Mutations in this gene have been found in patients with Emery-Dreifuss muscular dystrophy. Multiple alternately spliced transcript variants which encode different protein isoforms have been described.

Gene names and symbols associated with FHL1

  • four and a half LIM domains 1 (fhl1)
  • four and a half LIM domains 1 (FHL1)
  • four and a half LIM domains 1 (LOC100357263)
  • four and a half LIM domains 1a (fhl1a)
  • Four and a half LIM domains protein 1 (fhl1)
  • four and a half lim domains protein 1 (fhl1)
  • four and a half LIM domains 1 (Fhl1)
  • four and a half LIM domains 1 protein, isoform C (FHL1C)
  • DKFZp468O1927 protein
  • fhl protein
  • FHL-1 protein
  • Fhl1 protein
  • FHL1A protein
  • FHL1B protein
  • fhla protein
  • FLH1A protein
  • KyoT protein
  • MGC89165 protein
  • SLIM protein
  • SLIM-1 protein
  • SLIM1 protein
  • SLIMMER protein
  • XMPMA protein
  • zgc:92025 protein

Protein level used designations for FHL1

four and a half LIM domains 1 , four and a half LIM domains protein 1-like , four and a half LIM domains a , four and a half LIM domains protein 1 , Four and a half LIM domains protein 1 , four and a half lim domains protein 1 , LIM protein SLIMMER , four-and-a-half Lin11, Isl-1 and Mec-3 domains 1 , skeletal muscle LIM-protein 1 , FHL-1 , RAM14-1 , RBP-associated molecule 14-1 , SLIM , SLIM-1 , four and a half LIM domains 1 protein

GENE ID SPECIES
448334 Xenopus (Silurana) tropicalis
710692 Macaca mulatta
100172515 Pongo abelii
100307044 Ovis aries
100357263 Oryctolagus cuniculus
100387250 Callithrix jacchus
100590327 Nomascus leucogenys
399646 Danio rerio
100196873 Salmo salar
100529032 Ictalurus punctatus
447182 Xenopus laevis
2273 Homo sapiens
14199 Mus musculus
25177 Rattus norvegicus
509056 Bos taurus
397667 Sus scrofa
492162 Canis lupus familiaris
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