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Four and A Half LIM Domains 2 Proteins (FHL2)

FHL2 encodes a member of the four-and-a-half-LIM-only protein family. Additionally we are shipping Four and A Half LIM Domains 2 Antibodies (73) and Four and A Half LIM Domains 2 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FHL2 2274 Q14192
FHL2 14200 O70433
FHL2 63839 O35115
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Top Four and A Half LIM Domains 2 Proteins at antibodies-online.com

Showing 8 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,731.67
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,731.67
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$510.36
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 9 to 11 Days
$229.85
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

FHL2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Four and A Half LIM Domains 2 (FHL2) Interaction Partners

Pig (Porcine) Four and A Half LIM Domains 2 (FHL2) interaction partners

  1. Fibroblast growth factor-2 (show FGF2 Proteins) promotes in vitro heart valve interstitial cell repair through the Akt1 (show AKT1 Proteins) pathway.

  2. The overlapping relationships of 3'UTR ends between NUDT6 (show NUDT6 Proteins) and FGF-2 (show FGF2 Proteins) genes, were analyzed.

  3. FGF2 (show FGF2 Proteins) in porcine ovary may be important for the growth of more follicles due to the localisation and concentration difference between stroma and follicle tissue.

  4. By inducing the release of an endothelial elastase, shear stress induces an integrin-dependent release of FGF-2 (show FGF2 Proteins) from endothelial cells.

  5. qPCR analysis demonstrated an increase in FGF-2 (show FGF2 Proteins) mRNA levels beginning on day 75 and on day 114 of pregnancy.

  6. FGF2 (show FGF2 Proteins) activates FGFR (show FGFR2 Proteins) which then represses the fibroblast activation of valvular interstitial cells.

  7. FGF2 (show FGF2 Proteins) effectively blocks transforming growth factor-beta1 (TGF-beta1 (show TGFB1 Proteins))-mediated myofibroblast activation

  8. upregulation of TGFalpha or FGF2 (show FGF2 Proteins) expression is not a pre-requisite for enhanced testicular growth and increased Sertoli cell proliferation that occurs subsequent to hemicastration in the neonatal boar

Human Four and A Half LIM Domains 2 (FHL2) interaction partners

  1. KLF8 (show KLF8 Proteins)-induced FHL2 activation is a novel and critical signaling mechanism underlying human colorectal cancer invasion and metastasis.

  2. Studies indicate that the LIM (show PDLIM5 Proteins)-only protein FHL2 interactome is functionally involved in the cardiovascular system.

  3. we conclude that FHL2 has both structural and functional protein-protein interactions with b-catenin in the podocyte nucleus and that FHL2 protein inhibition can mitigate Wnt/b-catenin-induced podocytopathy.

  4. Describe the molecular network governing FHL2 expression, and FHL2-linked cancers and the underlying molecular machinery. Review.

  5. Tumoral expression of nuclear cofactor FHL2 is associated with lymphatic metastasis in sporadic but not in hereditary nonpolyposis colorectal cancer-associated colorectal cancer.

  6. results provide evidence for the importance of the focal adhesion protein FHL2 in pancreatic cancer cell survival, proliferation and radiosensitivity

  7. FHL2 is down-regulated in HCM; both FHL2 wild type and variants partially protected phenylephrine- or endothelin-1 (show EDN1 Proteins)-induced hypertrophy in cardiac myocytes

  8. FHL2 downregulation has a role in the pathogenesis of myeloid malignancies.

  9. HPV16 E6 oncoprotein interacted and impaired the subcellular distribution of FHL2.

  10. tumoural TGF-beta1 secretion seems to induce nuclear translocation of co-factor FHL2 mediating progressive keratin expression in pilomatricoma.

Mouse (Murine) Four and A Half LIM Domains 2 (FHL2) interaction partners

  1. Overexpression of FHL2 alone had no effect on Erbin (show ERBB2IP Proteins) expression, but in the presence of MITF (show MITF Proteins), Erbin (show ERBB2IP Proteins) expression was decreased.

  2. these data identify a previously unrecognized role for FHL2 in the pathogenesis of pulmonary granulomatous inflammation

  3. we conclude that FHL2 has both structural and functional protein-protein interactions with b-catenin in the podocyte nucleus and that FHL2 protein inhibition can mitigate Wnt/b-catenin-induced podocytopathy.

  4. FHL2 serves as a protective factor and that, rather than promoting the pathology, the upregulation of FHL2 in RA occurs in frame of a regenerative attempt.

  5. FHL2 regulates hematopoietic stem cell functions under transplantation-induced stress conditions.

  6. The LIM (show PDLIM5 Proteins)-only protein FHL2 reduces vascular lesion formation involving inhibition of proliferation and migration of smooth muscle cells.

  7. a database of genes that are regulated by FHL2 in liver

  8. FHL2-deficient mice developed a severe and long-lasting lung pathology due to enhanced expression of tenascin C (show TNC Proteins) and impaired activation of inflammation-resolving macrophages.

  9. Early Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins)-dependent transcriptional activation mediated by FHL2 is important for the transition to and expansion of early cardiogenic mesodermal cells.

  10. Deficiency of FHL2 reduced susceptibility to diethylnitrosamine-induced hepatocarcinogenesis, correlating with the activator function of FHL2 in NF-kappaB (show NFKB1 Proteins) signaling.

Four and A Half LIM Domains 2 (FHL2) Protein Profile

Protein Summary

This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Gene names and symbols associated with FHL2

  • four and a half LIM domains 2 (FHL2)
  • four and a half LIM domains 2 (fhl2)
  • four and a half LIM domains 2 (LOC100219958)
  • fibroblast growth factor 2 (basic) (FGF2)
  • fibroblast growth factor 2 (basic) (fgf2)
  • fibroblast growth factor 2 (basic) (LOC100227798)
  • four and a half LIM domains 2 (Fhl2)
  • AAG11 protein
  • BFGF protein
  • C76204 protein
  • DRAL protein
  • FGF-2 protein
  • fgfb protein
  • FHL-2 protein
  • FHL2 protein
  • HBGF-2 protein
  • HBGF2 protein
  • hbgh-2 protein
  • LOC100227798 protein
  • SLIM-3 protein
  • SLIM3 protein
  • xfgf2 protein

Protein level used designations for FHL2

four and a half LIM domains 2 , basic fgf , basic fibroblast growth factor , HBGF-2 , fibroblast growth factor 2 , heparin-binding growth factor 2 , prostatropin , fibroblast growth factor 2 (basic) , LIM domain protein DRAL , aging-associated gene 11 , down-regulated in rhabdomyosarcoma LIM protein , four and a half LIM domains protein 2 , skeletal muscle LIM-protein 3 , FHL-2 , SLIM-3 , SLIM 3

GENE ID SPECIES
459469 Pan troglodytes
100145283 Xenopus (Silurana) tropicalis
100219958 Taeniopygia guttata
397643 Sus scrofa
550087 Xenopus (Silurana) tropicalis
574136 Macaca mulatta
619384 Monodelphis domestica
100033955 Equus caballus
100227798 Taeniopygia guttata
2274 Homo sapiens
474544 Canis lupus familiaris
510008 Bos taurus
14200 Mus musculus
63839 Rattus norvegicus
100513532 Sus scrofa
418726 Gallus gallus
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