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anti-Fragile Histidine Triad (FHIT) Antibodies

FHIT, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. Additionally we are shipping FHIT Proteins (30) and FHIT Kits (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
FHIT 2272 P49789
FHIT 60398 Q9JIX3
FHIT 14198 O89106
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Top anti-FHIT Antibodies at antibodies-online.com

Showing 10 out of 126 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using FHIT (Phospho-Tyr114) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Mouse Mouse Un-conjugated IF, WB Western blot analysis of FHIT on mouse liver lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of anti-FHIT. Immunofluorescent staining of L6 cells. 50 μg Log in to see 5 to 6 Days
$220.08
Details
Human Rabbit Un-conjugated IF (p), IHC (p) Formalin-fixed and paraffin embedded rat kidney labeled with Anti-FHIT Polyclonal Antibody, Unconjugated (ABIN734198) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Mouse Un-conjugated WB FHIT monoclonal antibody (M01), clone 1E3 Western Blot analysis of FHIT expression in HL-60. Detection limit for recombinant GST tagged FHIT is approximately 0.03 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged FHIT is approximately 3 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-FHIT Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Human kidney WB Suggested Anti-FHIT  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500  Positive Control: Human kidney 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IF, IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- FHIT Picoband antibody, IHC(P) IHC(P): Human Mammary Cancer Tissue Anti- FHIT Picoband antibody, Western blotting All lanes: Anti FHIT  at 0.5ug/ml WB: Recombinant Human FHIT Protein 0.5ng Predicted bind size: 39KD Observed bind size: 39KD 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB Western blot analysis of extracts from A549 cells, using FHIT Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using FHIT Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of FHIT staining in HEK293T cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of FHIT staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 9 Days
$487.50
Details

FHIT Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-FHIT Antibodies

  1. Human Monoclonal FHIT Primary Antibody for WB - ABIN394498 : Yin, Wang, Sun, Yin, Yan, Shen, Gao, He: Homozygous deletion but not mutation of exons 5 and 8 of the fragile histidine triad (FHIT) gene is associated with features of differentiated thyroid carcinoma. in Annals of clinical and laboratory science 2010 (PubMed)
    Show all 5 references for ABIN394498

  2. Human Monoclonal FHIT Primary Antibody for ELISA, WB - ABIN395220 : Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010 (PubMed)
    Show all 5 references for ABIN395220

  3. Mouse (Murine) Monoclonal FHIT Primary Antibody for IF, WB - ABIN968653 : Fong, Fidanza, Zanesi, Lock, Siracusa, Mancini, Siprashvili, Ottey, Martin, Druck, McCue, Croce, Huebner: Muir-Torre-like syndrome in Fhit-deficient mice. in Proceedings of the National Academy of Sciences of the United States of America 2000 (PubMed)
    Show all 3 references for ABIN968653

  4. Human Polyclonal FHIT Primary Antibody for IF (p), IHC (p) - ABIN734198 : Liu, Ao, Zhou, Cui, Zhou, Yuan, Xiang, Cao, Liu: CpG island hypermethylation of multiple tumor suppressor genes associated with loss of their protein expression during rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine. in Biochemical and biophysical research communications 2010 (PubMed)

  5. Human Polyclonal FHIT Primary Antibody for IHC, ELISA - ABIN1532181 : Ohta, Inoue, Cotticelli, Kastury, Baffa, Palazzo, Siprashvili, Mori, McCue, Druck, Croce, Huebner: The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers. in Cell 1996 (PubMed)

More Antibodies against FHIT Interaction Partners

Human Fragile Histidine Triad (FHIT) interaction partners

  1. FHIT hypermethylation, which induces the inactivation of FHIT gene, plays an important role in the carcinogenesis and clinical outcome and may serve as a potential diagnostic marker and drug target of non-small-cell lung carcinoma

  2. Low FHIT Gene Expression is associated with Acute Lymphoblastic Leukemia.

  3. In 22 lung cancer patients with negative histology and cytology at initial bronchoscopy, FHIT and p16 (show CDKN2A Antibodies) mRNA loss was detected in 40.9% (9/22) and 36.4% (8/22) cases, respectively.

  4. The results showed that the methylation levels of both BRCA1 and FHIT promoters were higher in the serum of the breast ductal carcinoma group than those of the breast fibroadenoma group.

  5. Review/Meta-analysis: FHIT methylation could be a diagnostic biomarker of breast carcinogenesis.

  6. Mutations of the FHIT gene are not major cause of Peutz-Jeghers syndrome.

  7. Adenylylsulfate-ammonia adenylyltransferase activity is another inherent property of Fhit proteins.

  8. APOBEC3B overexpression and Fhit-loss induced DNA damage are independent events that, when occurring together, result in a significantly increased frequency of APOBEC-induced mutations that drive cancer progression.

  9. Hypermethylation of FHIT gene is associated with Epstein-Barr virus-associated gastric carcinomas.

  10. FHIT promotor hypermethylation is associated with the development of breast cancer.

Mouse (Murine) Fragile Histidine Triad (FHIT) interaction partners

  1. Fhit-deficiency mutation signature also resembles a C>T and T>C mutation signature reported for human papillary kidney cancers and a similar signature recently reported for esophageal and bladder cancers, cancers that are frequently Fhit deficient.

  2. Fhit deficiency-induced global genome instability promotes mutation and clonal expansion

  3. Fhit delocalizes annexin A4 (show ANXA4 Antibodies) from plasma membrane to cytosol and sensitizes lung cancer cells to paclitaxel.

  4. FHIT gene is a "caretaker gene" necessary for maintenance of genome stability.

  5. Loss of Fhit expression contributes to cell transformation.

  6. Defects in Fhit expression may promote MHC-I down-regulation in cancer cells and allow escape from immunosurveillance.

  7. Human and mouse orthologous genes, FHIT and Fhit, are more highly conserved through evolution than PTPRG/Ptprg (show PTPRG Antibodies) and yet contain more sequence elements that are exquisitely sensitive to genomic rearrangements

  8. Association of Fhit gene inactivation with increased survival after DNA damage, related to over-active checkpoints regulated by ATR/CHK1 pathway. Potential effects of Fhit-dependent DNA damage response on tumor progression.

  9. Fhit has a role in bladder cancer development

  10. UV-induced alterations of the FHIT and WWOX (show WWOX Antibodies) fragile site gene expression are involved at least partially in the checkpoint function of DNA damage

Cow (Bovine) Fragile Histidine Triad (FHIT) interaction partners

  1. the same mRNA isoforms of FHIT were detected in bladder tumors and in healthy tissues, including a novel isoform that was found in this study, suggesting that epigenetic modifications and altered expression profiles are not a hallmark of vesical tumors

FHIT Antigen Profile

Protein Summary

This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with FHIT

  • fragile histidine triad (FHIT) antibody
  • fragile histidine triad (Fhit) antibody
  • fragile histidine triad gene (Fhit) antibody
  • fragile histidine triad gene (FHIT) antibody
  • AP3Aase antibody
  • AW045638 antibody
  • FRA3B antibody
  • Fra14A2 antibody

Protein level used designations for FHIT

AP3A hydrolase , bis(5'-adenosyl)-triphosphatase , diadenosine 5',5'''-P1,P3-triphosphate hydrolase , dinucleosidetriphosphatase , tumor suppressor protein , AP3Aase , fragile histidine triad protein , diadenosine triphosphate hydrolase

GENE ID SPECIES
2272 Homo sapiens
100215999 Canis lupus familiaris
60398 Rattus norvegicus
416071 Gallus gallus
14198 Mus musculus
692183 Bos taurus
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